Protein Alignment Cyp6g1 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_610743.2
• Gene: Cyp6g1 / 36316
• FlyBaseID: FBgn0025454
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 122/518 - (23%)
• Similarity: 219/518 - (42%)
• Gaps: 80/518 - (15%)

  Fly    10 VVAALVALYTWFQRNHSYWQRKGIPYIPPTP--IIGNTKVVFKMENSFGMHLSEIYNDPRLKDEA 72
            |:.|.....|:..|..|.::.  ||. ||.|  ::|:....:|.:...|..|.:::.|...|...
Human    12 VLLAFGLCCTFVHRARSRYEH--IPG-PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGP 73

  Fly    73 VVGIYSMNKPGLIIRDIELIKSILIK-DFNRFHNRY-ARCDPHGDPL-GYNNLFFVRDAHWKGIR 134
            ||.:...:|..:|:...|.:|..|:. .:|:....| |.....|:.| |...:.......|...|
Human    74 VVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQR 138

  Fly   135 TKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIAFGIR 199
            ..:...|:.   ..:.:||:...:..|..::....|..|.....::::....:.|.:|..|||:.
Human   139 RVIDLAFSR---SSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200

  Fly   200 ANSL---ENPNAEFRNYGRKMFTFTVARAKDFFVAFFLPKLVSLMRIQFFTADFSHFMRSTIGHV 261
            .:.|   :.|.::    ..|:....:..:::....|...|...|..::    :...|:|. :|..
Human   201 TSMLLGAQKPLSQ----AVKLMLEGITASRNTLAKFLPGKRKQLREVR----ESIRFLRQ-VGRD 256

  Fly   262 MEERERSGLLRNDLI--DVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETSSSTMSFA 324
            ..:|.|..|.|.:.:  |:|..:.|   ||..    |::.:.|:.....||.||.|||::.::|.
Human   257 WVQRRREALKRGEEVPADILTQILK---AEEG----AQDDEGLLDNFVTFFIAGHETSANHLAFT 314

  Fly   325 LYEMAKHPEMQKRLRDEINEALVEGGGS---LSYEKIQSLEYLAMVVDEVLRMYP----VLPFLD 382
            :.|:::.||:..||:.|::|.:    ||   |.:|.:..|:||:.|:.|.||:||    ....|:
Human   315 VMELSRQPEIVARLQAEVDEVI----GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLE 375

  Fly   383 REYESVEGQPDLSLKPFYDYTLENG------TPVFIPIYALHHDPKYWTNPSQFDPERFSPANRK 441
            .|                  ||.:|      ||:....|.:.....|:.:|..|:|:||.|...|
Human   376 EE------------------TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK 422

  Fly   442 NIVAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVR---------NCEATMKDMKFDP 495
              ....|.||..|..:|||.:...::.|:.:..||:....|         ..:||:|.:  ||
Human   423 --PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPL--DP 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_610743.2	CYP6-like	69..507	CDD:410679	107/457 (23%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	108/466 (23%)