DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rrp9 and U3-55K

DIOPT Version :9

Sequence 1:	NP_001102248.1	Gene:	Rrp9 / 363134	RGDID:	1307881	Length:	478	Species:	Rattus norvegicus
Sequence 2:	NP_001014529.1	Gene:	U3-55K / 3346176	FlyBaseID:	FBgn0053505	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	202/483 - (41%)
Similarity:	294/483 - (60%)	Gaps:	48/483 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    20 PGAAPVDGKRRRKVDSAASRGK--SKGG--GKM------------------NEEISSDSE----- 57
            |||   .|.::||..:|.::||  .|||  ||.                  :|||:||.|
  Fly     9 PGA---KGTKKRKNPAATTKGKPLKKGGKPGKSTPAAGGPVPKKQRRPKEEDEEIASDDEEYNSD 70

  Rat    58 ----SESLAPRKTEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKED 118
                ..:||....|.|     |||.|:|:|||||.||.::.:||.|:||.|...: .|..||:.:
  Fly    71 LGGDDNTLAFSSDEGE-----EETPQDKRLRLAKQYLSEIEKQEAERAEDRELAQ-SVEQRLQTE 129

  Rat   119 VLEQRGRLQKLVAKEIQAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGR- 182
            .|:..|:|::.:|..::|...:.|...:.|...|..|.::||...:::.||...::||..|||:
  Fly   130 YLDSVGKLRRNIAGSLKACESSRILKHKLHHTPICALALSPDGKFLYTGAKSQFLLKWCTETGKV 194

  Rat   183 --KLHVIPRAKKGTQGQPSGHSSHILCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRD 245
              |..|:...::...|:.  ..||::.:.:|||.||||..:....|.||..|:.:|:.|..||||
  Fly   195 LEKSDVLSHREEPETGKK--RRSHVISICLSSDMKYLALAEGGPHIQIWCPQTMKHIKTLKGHRD 257

  Rat   246 AVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTV 310
            :|:||.||:|||.|||.:.|||||:|:..|.:|||:|||||.||.::||||||..:||||.|.::
  Fly   258 SVAGLVFRKGTHDLYSAAKDRSVKIWSLDEMAYVESLFGHQTAVTSIDALSRERAITAGGSDCSL 322

  Rat   311 RVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEPG 375
            |:|||.|||||::.||:.||:|:..||:||.|||..||::.||...||:|:...:.|||: ||.|
  Fly   323 RIWKITEESQLIYNGHKDSIECVKYINDEHFVSGGMDGAIGLWSALKKKPICTTQLAHGV-GENG 386

  Rat   376 LEQPFWISSVAALLNTDLVATGSHNACVRLWQCGEGFRQLDPLCDIPLVGFINSLKFSSGGDFLV 440
            :..  ||:::|.::|||||||||.:.||||||.....|:::.:..|.:.||||.|.|::.|..|.
  Fly   387 VAN--WITAIAVVVNTDLVATGSCDGCVRLWQTNPNARKMNLIQSISIAGFINGLAFNADGSKLF 449

  Rat   441 AGVGQEHRLGRWWRIKEARNSVCIIPLR 468
            ...|||||||||||:|||:|.|.::.::
  Fly   450 VATGQEHRLGRWWRLKEAKNQVVVLDVK 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp9	NP_001102248.1	WD40	142..442	CDD:238121	136/302 (45%)
		WD40 repeat	152..200	CDD:293791	14/50 (28%)
		WD40 repeat	206..242	CDD:293791	13/35 (37%)
		WD40 repeat	247..283	CDD:293791	21/35 (60%)
		WD40 repeat	290..323	CDD:293791	20/32 (63%)
		WD40 repeat	330..366	CDD:293791	16/35 (46%)
		WD40 repeat	382..424	CDD:293791	19/41 (46%)
		WD40 repeat	427..452	CDD:293791	13/24 (54%)
U3-55K	NP_001014529.1	Upf2	55..>125	CDD:281974	29/75 (39%)
		WD40	<150..484	CDD:225201	152/333 (46%)
		WD40	156..416	CDD:295369	123/264 (47%)
		WD40 repeat	163..203	CDD:293791	13/39 (33%)
		WD40 repeat	218..254	CDD:293791	13/35 (37%)
		WD40 repeat	259..295	CDD:293791	21/35 (60%)
		WD40 repeat	302..336	CDD:293791	20/33 (61%)
		WD40 repeat	342..379	CDD:293791	16/36 (44%)
		WD40 repeat	391..431	CDD:293791	18/39 (46%)
		WD40 repeat	436..461	CDD:293791	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341724
Domainoid	1	1.000	58	1.000	Domainoid score	I10547
eggNOG	1	0.900	-	-		E1_KOG0299
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3452
Inparanoid	1	1.050	361	1.000	Inparanoid score	I2129
OMA	1	1.010	-	-		QHG54739
OrthoDB	1	1.010	-	-		D453052at33208
OrthoFinder	1	1.000	-	-		FOG0004346
OrthoInspector	1	1.000	-	-		oto96410
orthoMCL	1	0.900	-	-		OOG6_102033
Panther	1	1.100	-	-	LDO	PTHR19865
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3065
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770