Protein Alignment wash and wash1

DIOPT Version :10

• Sequence 1: NP_610739.1
• Gene: wash / 36311
• FlyBaseID: FBgn0033692
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001103920.1
• Gene: wash1 / 555174
• ZFINID: ZDB-GENE-050419-138
• Length: 481
• Species: Danio rerio
• Alignment Length: 541
• Identity: 171/541 - (31%)
• Similarity: 237/541 - (43%)
• Gaps: 108/541 - (19%)

  Fly     1 MEESPYLHSP-YQVAIIATDLHHEDTIIQAAQSLDCLHKTINSIFERIDARLARNGSKVEDINNR 64
            |.:..||... |.|.:|..||..|:.:.|...:|..|......||.|:...:.:|.:.::.:.:|
Zfish     4 MTQKRYLEGQVYSVPLIQPDLRREEAVHQITDALQYLEMISTDIFTRVSESVEKNRAHLQSVTDR 68

  Fly    65 VKRAQAKIDALVGSKRAIQIFAPARFPASDVLAPLPATFPQVAANPLMEQQVDQLPQGTYSSHSA 129
            :|.|||::..:.|||:|.::|:.|::||.:.|....:.|.. |.:|
Zfish    69 IKLAQARVQKIKGSKKATKVFSSAKYPAPEKLQDYSSIFTG-AVDP------------------- 113

  Fly   130 ADQKPDDADIFFHVR--GDREQESPLV--------AERKITNRTAGLGILPAGGVRSVPSLMRFN 184
            |.||.....:...:|  .|:.|:..|:        .:|.......|||.||. .|.||.||:.||
Zfish   114 ASQKRPRIKVQSKLRPLDDKAQQEKLMYLPVCVNTKKRSEDETEEGLGSLPR-NVNSVSSLLLFN 177

  Fly   185 TNEFAYGEDLNAWKR--SLPPQNARRVASQSTQLTGEKQLAP--APHSLAHGTTKLATPAGDLRY 245
            |.|       |.:|:  .|.|. |..|....|.|..||:..|  ||.|:..........|.:..|
Zfish   178 TTE-------NLYKKYVFLDPL-AGAVTKTHTTLETEKEDKPFDAPLSITKREQLERQTAENYFY 234

  Fly   246 NPAALAAPAIDVPLDLPDLPGIANDLQYEPVEEQTPIAPS-QQFGDLPELPDLGLEEQDIIVQAI 309
            .|.....|.||||..||||||||:||.|. .:.....||| .....:||||..|.:..:
Zfish   235 VPDLGQVPEIDVPSYLPDLPGIADDLMYS-ADLGPGFAPSVPASNSIPELPSFGTDHDE------ 292

  Fly   310 AAQTHIPGPVRRKSVGQCPSPVTAAPPPPPPPPPPPPPP-----PPAQTSAIPSPPPFPTKGAVK 369
                         |.|........|||||||||||||.|     ||..|||.|.|||.|     .
Zfish   293 -------------SSGSDSQFKLEAPPPPPPPPPPPPEPTHVPVPPPGTSAAPPPPPPP-----P 339

  Fly   370 PLSPSLATPLNMPQPPPAT-----------EDPRSELMAAIRNAGGVHGGRLRSPAAAPLDVVDN 423
            |::.. .|..:.|.||..|           .:.|:.|:.:||||||:....||:.....::....
Zfish   340 PITAD-NTDASSPAPPTGTVKGAPSEVVQPSNGRASLLESIRNAGGIGKANLRNVKERKMEKKKQ 403

  Fly   424 SRSKAGGAVT--GDLMADLHNKLMLRRKGISG---------SQNPVEATAGNPLMQQLSRVIPPP 477
            ...:..||..  ||||:||.|||.:|||||||         |:.|  |::|: ...::|.||||.
Zfish   404 KEQEQVGATVSGGDLMSDLFNKLAMRRKGISGKGPAGQGDSSEAP--ASSGS-AFARMSDVIPPL 465

  Fly   478 VQPRKGSKSSDEHSEDDEDGW 498
            ..|:       :.:.||||.|
Zfish   466 PAPQ-------QSAADDEDDW 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wash	NP_610739.1	WASH_WAHD	11..307	CDD:463408	93/310 (30%)
wash1	NP_001103920.1	Required for WASH complex assembly. /evidence=ECO:0000250|UniProtKB:C4AMC7	1..54		15/49 (31%)
		WASH_WAHD	14..299	CDD:463408	95/333 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..417		50/168 (30%)
		VCA. /evidence=ECO:0000250|UniProtKB:C4AMC7	359..481		43/131 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..481		22/61 (36%)