DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wash and washc1

DIOPT Version :9

Sequence 1:	NP_001286334.1	Gene:	wash / 36311	FlyBaseID:	FBgn0033692	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001016854.1	Gene:	washc1 / 549608	XenbaseID:	XB-GENE-5947821	Length:	472	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	169/523 - (32%)
Similarity:	231/523 - (44%)	Gaps:	99/523 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YQVAIIATDLHHEDTIIQAAQSLDCLHKTINSIFERIDARLARNGSKVEDINNRVKRAQAKIDAL 75
            |.:.:|..||..|:.|.|...:|..|....|.||.||..|:..|..:::.||.|:..|||||:.|
Frog    12 YSLPLILPDLRREEAIHQITDTLQHLQTVSNDIFSRILQRVETNRGQLQRINGRLSLAQAKIERL 76

  Fly    76 VGSKRAIQIFAPARFPASDVLAPLPATFP---------------QVAANPLMEQQVDQLPQGTYS 125
            .|.|:||::|:.|::||.:.|....:.|.               |....||.||
Frog    77 KGIKKAIKVFSSAKYPAPEHLQEYSSVFAGAEDGWLAKKLRHKIQSKHRPLDEQ----------- 130

  Fly   126 SHSAADQKPDDADIFFHVRGDREQESPLVAERKITNRTAGLGILPAGGVRSVPSLMRFNTNEFAY 190
               |..:|.....:..:.||..|:.    ||.       |||.||. .:.||.||:.|||.|
Frog   131 ---AVQEKLKYFPVCVNTRGQDEES----AEE-------GLGSLPR-NISSVSSLLLFNTTE--- 177

  Fly   191 GEDLNAWKR--SLPPQNARRVASQSTQLTG--EKQLAPAPHSLAHGTTKLATPAGDLRYNPAALA 251
                |.:|:  .|.|. |..|...:..|.|  |::|..||.|:..........|.:..|.|....
Frog   178 ----NLYKKYVFLDPL-AGVVTRTNPALEGEDEEKLFDAPLSITKREQLERQTAENYFYVPDLGQ 237

  Fly   252 APAIDVPLDLPDLPGIANDLQYEPVEEQTPIAPSQQFGDLPELPDLGLEEQDIIVQAIAAQTHIP 316
            .|.||||..||||||:|:||.|. .:....||||.....:||||                 |.|.
Frog   238 VPEIDVPYSLPDLPGVADDLMYS-ADLGPGIAPSAPGVPIPELP-----------------TFIT 284

  Fly   317 GPVRRKSVGQCPSPVTAAPPPPPPPPPPPPPPPPAQTSAIPSP----PPFPTKGAVKPLSPSLAT 377
            ..:...|  :..|......|||||||||||||||.:.|.:..|    ||.|.....:..|..:..
Frog   285 EDITENS--RTDSQDGRLLPPPPPPPPPPPPPPPPEPSVLSPPTSLAPPLPIPAPARVGSSDVGD 347

  Fly   378 PLNMPQPPPATEDP---RSELMAAIRNAGGVHGGRLRSPAAAPLD-----VVDNSRSKAGGAVTG 434
            |.::...|....:|   |:.|:.:||.|||:...:||:.....|:     ..:..|:..||   |
Frog   348 PGSLQGAPKEVVNPSDGRASLLESIRQAGGIGKAKLRNVKEKKLEKKKMKEQEQVRATGGG---G 409

  Fly   435 DLMADLHNKLMLRRKGISGSQNPV--EATAGNP--LMQQLSRVIPPPVQPRKGSKSSDEHSEDDE 495
            |||:||.|||.:||||||| :.|.  ||:...|  ...::|..|||...|.:.|      .:.||
Frog   410 DLMSDLFNKLAMRRKGISG-KGPAAGEASGDGPTGAFARISDTIPPLPPPDQAS------GDGDE 467

  Fly   496 DGW 498
            :.|
Frog   468 EDW 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wash	NP_001286334.1	WASH_WAHD	11..301	CDD:288773	99/308 (32%)
washc1	NP_001016854.1	Required for WASH complex assembly. /evidence=ECO:0000250\|UniProtKB:C4AMC7	1..51		14/38 (37%)
		WASH_WAHD	11..296	CDD:371812	102/337 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..365		26/77 (34%)
		VCA. /evidence=ECO:0000250\|UniProtKB:C4AMC7	352..472		44/129 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..412		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..472		16/52 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6412
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45706
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3781
OMA	1	1.010	-	-		QHG54361
OrthoDB	1	1.010	-	-		D386666at33208
OrthoFinder	1	1.000	-	-		FOG0004493
OrthoInspector	1	1.000	-	-		oto104177
Panther	1	1.100	-	-	LDO	PTHR23331
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3513
SonicParanoid	1	1.000	-	-		X3782
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110