Protein Alignment wash and washc1

DIOPT Version :10

• Sequence 1: NP_610739.1
• Gene: wash / 36311
• FlyBaseID: FBgn0033692
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001016854.1
• Gene: washc1 / 549608
• XenbaseID: XB-GENE-5947821
• Length: 472
• Species: Xenopus tropicalis
• Alignment Length: 523
• Identity: 169/523 - (32%)
• Similarity: 231/523 - (44%)
• Gaps: 99/523 - (18%)

  Fly    11 YQVAIIATDLHHEDTIIQAAQSLDCLHKTINSIFERIDARLARNGSKVEDINNRVKRAQAKIDAL 75
            |.:.:|..||..|:.|.|...:|..|....|.||.||..|:..|..:::.||.|:..|||||:.|
 Frog    12 YSLPLILPDLRREEAIHQITDTLQHLQTVSNDIFSRILQRVETNRGQLQRINGRLSLAQAKIERL 76

  Fly    76 VGSKRAIQIFAPARFPASDVLAPLPATFP---------------QVAANPLMEQQVDQLPQGTYS 125
            .|.|:||::|:.|::||.:.|....:.|.               |....||.||
 Frog    77 KGIKKAIKVFSSAKYPAPEHLQEYSSVFAGAEDGWLAKKLRHKIQSKHRPLDEQ----------- 130

  Fly   126 SHSAADQKPDDADIFFHVRGDREQESPLVAERKITNRTAGLGILPAGGVRSVPSLMRFNTNEFAY 190
               |..:|.....:..:.||..|:.    ||.       |||.||. .:.||.||:.|||.|
 Frog   131 ---AVQEKLKYFPVCVNTRGQDEES----AEE-------GLGSLPR-NISSVSSLLLFNTTE--- 177

  Fly   191 GEDLNAWKR--SLPPQNARRVASQSTQLTG--EKQLAPAPHSLAHGTTKLATPAGDLRYNPAALA 251
                |.:|:  .|.|. |..|...:..|.|  |::|..||.|:..........|.:..|.|....
 Frog   178 ----NLYKKYVFLDPL-AGVVTRTNPALEGEDEEKLFDAPLSITKREQLERQTAENYFYVPDLGQ 237

  Fly   252 APAIDVPLDLPDLPGIANDLQYEPVEEQTPIAPSQQFGDLPELPDLGLEEQDIIVQAIAAQTHIP 316
            .|.||||..||||||:|:||.|. .:....||||.....:||||                 |.|.
 Frog   238 VPEIDVPYSLPDLPGVADDLMYS-ADLGPGIAPSAPGVPIPELP-----------------TFIT 284

  Fly   317 GPVRRKSVGQCPSPVTAAPPPPPPPPPPPPPPPPAQTSAIPSP----PPFPTKGAVKPLSPSLAT 377
            ..:...|  :..|......|||||||||||||||.:.|.:..|    ||.|.....:..|..:..
 Frog   285 EDITENS--RTDSQDGRLLPPPPPPPPPPPPPPPPEPSVLSPPTSLAPPLPIPAPARVGSSDVGD 347

  Fly   378 PLNMPQPPPATEDP---RSELMAAIRNAGGVHGGRLRSPAAAPLD-----VVDNSRSKAGGAVTG 434
            |.::...|....:|   |:.|:.:||.|||:...:||:.....|:     ..:..|:..||   |
 Frog   348 PGSLQGAPKEVVNPSDGRASLLESIRQAGGIGKAKLRNVKEKKLEKKKMKEQEQVRATGGG---G 409

  Fly   435 DLMADLHNKLMLRRKGISGSQNPV--EATAGNP--LMQQLSRVIPPPVQPRKGSKSSDEHSEDDE 495
            |||:||.|||.:||||||| :.|.  ||:...|  ...::|..|||...|.:.|      .:.||
 Frog   410 DLMSDLFNKLAMRRKGISG-KGPAAGEASGDGPTGAFARISDTIPPLPPPDQAS------GDGDE 467

  Fly   496 DGW 498
            :.|
 Frog   468 EDW 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wash	NP_610739.1	WASH_WAHD	11..307	CDD:463408	99/314 (32%)
washc1	NP_001016854.1	Required for WASH complex assembly. /evidence=ECO:0000250|UniProtKB:C4AMC7	1..51		14/38 (37%)
		WASH_WAHD	11..296	CDD:463408	102/337 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..365		26/77 (34%)
		VCA. /evidence=ECO:0000250|UniProtKB:C4AMC7	352..472		44/129 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..412		9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..472		16/52 (31%)