Protein Alignment EndoG and Endog

DIOPT Version :10

• Sequence 1: NP_610737.1
• Gene: EndoG / 36309
• FlyBaseID: FBgn0033690
• Length: 310
• Species: Drosophila melanogaster
• Sequence 2: NP_031957.1
• Gene: Endog / 13804
• MGIID: 1261433
• Length: 294
• Species: Mus musculus
• Alignment Length: 328
• Identity: 153/328 - (46%)
• Similarity: 190/328 - (57%)
• Gaps: 53/328 - (16%)

  Fly     1 MSAPRVGGVLALGATALGAFYLGTHVERERQHNGSTSG--------------LPRLPGLPTFGTV 51
            |.|.|.|..|||||.      ||...|..|:..|...|              ||.|||.|..||
Mouse     1 MRALRAGLTLALGAG------LGAAAEHWRRREGKAPGLLGRVPLLPVVAADLPALPGGPAGGT- 58

  Fly    52 SAASLIPAQENNVSLTATPSRIGQIMKYGFPGLDHVRSHSDYVLSYDRRNRVPHWVFEHLTAESV 116
                                  |::.|||.||:..:||...||||||.|.|...||.|.|..|.:
Mouse    59 ----------------------GELAKYGLPGVAQLRSRESYVLSYDPRTRGALWVLEQLRPERL 101

  Fly   117 AKNDAVDRSKCDFKQDESIHPFFRSQNTDYRRSGYDRGHMAAAGNHRLHQKHCDETFYLSNMAPQ 181
             :.|. |||.|||::|:|:|.:.|:.|.|||.||:||||:|||.|||..|:..|:||||||:|||
Mouse   102 -RGDG-DRSACDFREDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQRAMDDTFYLSNVAPQ 164

  Fly   182 VGQGFNRDAWNTLEAHVRRLTKTYSNVYVCTGPLYLPHKEDDGKSYVKYEVIGANTVAVPTHFYK 246
            |.. .|::|||.||.:.|.||:||.|||||||||:||..|.||||||||:|||.|.|||||||:|
Mouse   165 VPH-LNQNAWNNLERYSRSLTRTYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFK 228

  Fly   247 VIVGESADHKLHMESYVMPNQVISNDTPISVFQVPPESVERSAGLLFFDQI-----NRKQLTTIN 306
            |::.|:|..::.:.||||||..:....|:..|.||.||:||::||||...|     |.|.:|.
Mouse   229 VLILEAAGGQIELRSYVMPNAPVDETIPLERFLVPIESIERASGLLFVPNILARAGNLKAITA-- 291

  Fly   307 GKK 309
            |.|
Mouse   292 GSK 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EndoG	NP_610737.1	NUC	77..309	CDD:238043	128/236 (54%)
Endog	NP_031957.1	NUC	75..281	CDD:214683	117/208 (56%)
		Essential for deoxyribonuclease activity. /evidence=ECO:0000269|PubMed:32192768	283..293		3/11 (27%)