DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and CCT7

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_012424.1	Gene:	CCT7 / 853333	SGDID:	S000003647	Length:	550	Species:	Saccharomyces cerevisiae

Alignment Length:	542	Identity:	169/542 - (31%)
Similarity:	285/542 - (52%)	Gaps:	32/542 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IILRDQERQKRITGTDA------IKTHIMAARQIASTLKTSLGPKGLDKIMVSPDGDVTVTNDGA 76
            ::|::        ||||      |.::|.|...:...||.:|||.|.|.::|:.:...|::||||
Yeast    11 VVLKE--------GTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGA 67

  Fly    77 TIMKLMEVDHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFELA 141
            ||:||::|.|..||.:|.:|::||.|:|||||.|.:|||.|:::|:..::.||....|..|:..|
Yeast    68 TILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKA 132

  Fly   142 AQCAIKQLDAIAQPFPVDPKN-KEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNVADIEKKDV 205
            ...|:::::.:|.....:..: :|.|.:.|.|.:.||:::.......:|.|||||:   :::.|:
Yeast   133 VSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLS---LDRNDL 194

  Fly   206 NFELIKIETKVGGRMEDSMLVKGVIVDKTLSHS---QMPKELRNVKLAILTCPFEPPKPKTKHKL 267
            :.:||.|:...||.||:|:.:.||...||.|::   |.||:..|.|:..|....|....|...::
Yeast   195 DDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEV 259

  Fly   268 DVTSAEDYRALREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGPEIE 332
            .|...|||:|:.:.|.:...:.::||::.||.:.:.:....|.|......:.:.....|...::.
Yeast   260 RVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMN 324

  Fly   333 LIAIATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMIIA 397
            .:..|.||.|.....::.||.||...|..||..|:  ::..:.:.|..:|..|:.||||...:||
Yeast   325 RVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGS--ERYNLFQGCPQAKTCTLLLRGGAEQVIA 387

  Fly   398 EAKRSIHDAICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIPLA 462
            |.:||:||||.:|:..:::..||.||||.|:..|..:...:..::..:|....||:.|||.||..
Yeast   388 EVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQ 452

  Fly   463 LAENSGLHPIETLSELK-ARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQLVK 526
            |.||:|...||.|::|: |....||...:..:....||:..|.  |.|....|...:..:|:...
Yeast   453 LCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKF--VWEPALVKINALNSATEATN 515

  Fly   527 MILKIDDV------RSKNEGGM 542
            :||.:|:.      .|.|.|.|
Yeast   516 LILSVDETITNKGSESANAGMM 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	165/534 (31%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	157/493 (32%)
CCT7	NP_012424.1	TCP1_eta	9..529	CDD:239456	165/532 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820