DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and TCP1

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_010498.1	Gene:	TCP1 / 851798	SGDID:	S000002620	Length:	559	Species:	Saccharomyces cerevisiae

Alignment Length:	528	Identity:	165/528 - (31%)
Similarity:	276/528 - (52%)	Gaps:	25/528 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KRITGTDAIKTHIMAARQIASTLKTSLGPKGLDKIMVSPDGDVTVTNDGATIMKLMEVDHEIAKL 91
            ::|:|.|....:::|...:|:.:|:||||.||||::|...||.|||||||||:.|::|.|...|:
Yeast    18 EKISGDDIRNQNVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDVQHPAGKI 82

  Fly    92 MVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFELAAQCAIKQLDAIAQPF 156
            :|:|:|.||.|||||||.||::|..||::|..|:...|||..|..||.:|.:.||:.::.:...
Yeast    83 LVELAQQQDREIGDGTTSVVIIASELLKRANELVKNKIHPTTIITGFRVALREAIRFINEVLST- 146

  Fly   157 PVDPKNKEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNV-ADIEKKDVNF--ELIKIETKVGG 218
            .||...||.||.||.|::.|||:.......:.|.|||:|.| ....|.::.:  :.:.:....|.
Yeast   147 SVDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKTQNSKGEIKYPVKAVNVLKAHGK 211

  Fly   219 RMEDSMLVKGVIVDKTLSHSQMPKELR--NVKLAILTCPFEPPKPKTKHKLDVTSAEDYRALREY 281
            ...:|:||.|..::.|::...|||.:.  |||:|.|....:..:.....::::...|....:|:.
Yeast   212 SATESLLVPGYALNCTVASQAMPKRIAGGNVKIACLDLNLQKARMAMGVQINIDDPEQLEQIRKR 276

  Fly   282 EQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGPEIELIAIATGGRIVPRF 346
            |.....:.||::.||||.:.:...|.||......::.::..||.....::..||.|||..:|...
Yeast   277 EAGIVLERVKKIIDAGAQVVLTTKGIDDLCLKEFVEAKIMGVRRCKKEDLRRIARATGATLVSSM 341

  Fly   347 EELTPEK------LGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMIIAEAKRSIHD 405
            ..|..|:      ||:...|.:..|  |.|:.::|:......:.:|.|||.|...:.|.:||:||
Yeast   342 SNLEGEETFESSYLGLCDEVVQAKF--SDDECILIKGTSKHSSSSIILRGANDYSLDEMERSLHD 404

  Fly   406 AICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIPLALAENSGLH 470
            ::.||:..::...:|.|||..|.:.::.:...|..:.:.||.|...|:.||..||..||.|:...
Yeast   405 SLSVVKRTLESGNVVPGGGCVEAALNIYLDNFATTVGSREQLAIAEFAAALLIIPKTLAVNAAKD 469

  Fly   471 PIETLSELK----ARQVAEKKS-------SLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQL 524
            ..|.:::|:    |.|:|:.:.       :.|:|.:.....|.....|:|...||.:.:..:.:.
Yeast   470 SSELVAKLRSYHAASQMAKPEDVKRRSYRNYGLDLIRGKIVDEIHAGVLEPTISKVKSLKSALEA 534

  Fly   525 VKMILKID 532
            ...||:||
Yeast   535 CVAILRID 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	165/528 (31%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	161/510 (32%)
TCP1	NP_010498.1	TCP1_alpha	17..549	CDD:239451	165/528 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820