Protein Alignment CCT5 and MKKS

DIOPT Version :10

• Sequence 1: NP_523707.1
• Gene: CCT5 / 36308
• FlyBaseID: FBgn0010621
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_061336.1
• Gene: MKKS / 8195
• HGNCID: 7108
• Length: 570
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 95/485 - (19%)
• Similarity: 185/485 - (38%)
• Gaps: 67/485 - (13%)

  Fly    32 TDAIKTHIMAARQIASTLKTSLGPKG-LDKIMVSPDGDVTVTNDGATIMKLMEVDHEIAKLMVQL 95
            |:.::|.:...::|.:   :..||.| |.::.....|.|..|:..:.::..:.|.|.|.|::...
Human    19 TERVRTTLSVLKRIVT---SCYGPSGRLKQLHNGFGGYVCTTSQSSALLSHLLVTHPILKILTAS 80

  Fly    96 SQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHP---IRIADGFELAAQC-AIKQLDAIAQPF 156
            .|:......|......:|...|:|..:.|   |:.|   ||:  ...|.:.| :..:.:......
Human    81 IQNHVSSFSDCGLFTAILCCNLIENVQRL---GLTPTTVIRL--NKHLLSLCISYLKSETCGCRI 140

  Fly   157 PVDPKNKEPLIQIAMTTLGSK----IVNKCHRQMAEMAVDA-VLNVADIEKKDVNFELIKIETKV 216
            |||..:.:.|:.:..:.|.||    :..|....::.:.:.| :|.:.:..:..:......|....
Human   141 PVDFSSTQILLCLVRSILTSKPACMLTRKETEHVSALILRAFLLTIPENAEGHIILGKSLIVPLK 205

  Fly   217 GGRMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKTKHKL---------DVTSA 272
            |.|:.||.::.|:::           |:..|:|..|.    |.|..|..|:         |.:..
Human   206 GQRVIDSTVLPGILI-----------EMSEVQLMRLL----PIKKSTALKVALFCTTLSGDTSDT 255

  Fly   273 EDYRALREYEQEKFTQMVKQVKDAG-------ATLAICQWGFDDEANHLLLQQELPAVRWVGGPE 330
            .:...:..|.......::.|:.:.|       ..|.:||..........|....:.|:..:|...
Human   256 GEGTVVVSYGVSLENAVLDQLLNLGRQLISDHVDLVLCQKVIHPSLKQFLNMHRIIAIDRIGVTL 320

  Fly   331 IELIAIATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMI 395
            :|.:...||.:.:.....:.|...|....|....||:.....|:..|   :...::.|...|...
Human   321 MEPLTKMTGTQPIGSLGSICPNSYGSVKDVCTAKFGSKHFFHLIPNE---ATICSLLLCNRNDTA 382

  Fly   396 IAEAKRSIHDAICVVRSLVKDSRIVYGGGAAEISCSL-----------AVAKEADQLSTLEQYAF 449
            ..|.|.:...|:.|::..:|:...:.|||..|...:.           ::.|:.:...|..|...
Human   383 WDELKLTCQTALHVLQLTLKEPWALLGGGCTETHLAAYIRHKTHNDPESILKDDECTQTELQLIA 447

  Fly   450 RAFSVALESIPLALAENSGLHPIETLSELK 479
            .||..||||:..:|..:.|    |.|:::|
Human   448 EAFCSALESVVGSLEHDGG----EILTDMK 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	95/485 (20%)
MKKS	NP_061336.1	Cpn60_TCP1	29..569	CDD:395068	93/475 (20%)
		Substrate-binding apical domain	198..370		34/189 (18%)