Protein Alignment CCT5 and Mkks

DIOPT Version :10

• Sequence 1: NP_523707.1
• Gene: CCT5 / 36308
• FlyBaseID: FBgn0010621
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_067502.2
• Gene: Mkks / 59030
• MGIID: 1891836
• Length: 570
• Species: Mus musculus
• Alignment Length: 490
• Identity: 95/490 - (19%)
• Similarity: 184/490 - (37%)
• Gaps: 81/490 - (16%)

  Fly    36 KTHIMAARQIASTLK-------TSLGPKG-LDKIMVSPDGDVTVTNDGATIMKLMEVDHEIAKLM 92
            ||..:.:.::.|||.       :..||.| |.::.....|.|..|:..:.:::.:.|.|.:.|::
Mouse    13 KTEPLTSEKVRSTLSVLKGVIASCYGPSGRLKQLHNGLGGCVYTTSQSSALLRNLSVTHPVLKIL 77

  Fly    93 VQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFELAAQCAIK---------- 147
            ....|:......|......:|...|:|..:.|              :|....|||
Mouse    78 TSSVQNHVSCFSDCGLFTAILCCNLIENIQRL--------------DLTPATAIKLNKYLLSLCT 128

  Fly   148 ---QLDAIAQPFPVDPKNKEPLIQIAMTTLGSK----IVNKCHRQMAEMAVDA-VLNVAD-IEKK 203
               :.:|.:...|||.::....:.:..:.|.||    :..|....:..:.:.| :|.:.: .|::
Mouse   129 SYLKSEACSCRIPVDFRSTHTFLSLVHSILTSKPACMLTRKETDHIGALILKAFLLTIPESTEER 193

  Fly   204 DVNFELIKIETKVGGRMEDSMLVKGVIVD------KTLSHSQMPKELRNVKLAILTCPFEPPKPK 262
            .|..:.|.:..| |.|:.||.::.|::::      :.|..:|....||    ..|.|
Mouse   194 MVLGKSIIVPLK-GQRVTDSTVLPGLLIEASEVQLRRLLPTQKASGLR----VALFC-------- 245

  Fly   263 TKHKLDVTSAEDYRALREYEQEKFTQMVKQVKDAG-------ATLAICQWGFDDEANHLLLQQEL 320
            |....|.::|.:...:..|:......:::|:.:.|       ..|.:||............::.:
Mouse   246 TSLSGDFSNAGEGVVVAHYQVSLENAVLEQLLNLGRRLVTDHVDLVLCQKVIHPSLKQFFSERHV 310

  Fly   321 PAVRWVGGPEIELIAIATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVT 385
            .|:..||...:|.::..||...:.....:.....|....|....||:.....|:..|   :...|
Mouse   311 MAIDRVGVTLMESLSKVTGATPIGSLNPIVSTTYGSVKDVCSARFGSKHFFHLLPNE---ATVCT 372

  Fly   386 IFLRGGNAMIIAEAKRSIHDAICVVRSLVKDSRIVYGGGAAEISCSL-----------AVAKEAD 439
            :.|...|.....|.|.:...|:.|::..:|:..::.|||..|...:.           |:.::..
Mouse   373 LLLCSRNDTAWEELKLTCQTAMHVLQLTIKEPWVLLGGGCTETHLAAYVRHKVHHEAEAIVRDDG 437

  Fly   440 QLSTLEQYAFRAFSVALESIPLALAENSGLHPIET 474
            ........|..||..||||:..:|..:.|...|:|
Mouse   438 CTQAKLHVAAEAFCSALESVAGSLEHDGGEILIDT 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	95/490 (19%)
Mkks	NP_067502.2	Cpn60_TCP1	29..569	CDD:395068	90/474 (19%)
		Substrate-binding apical domain. /evidence=ECO:0000250|UniProtKB:Q9NPJ1	198..370		34/187 (18%)