DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and cct5

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_997778.1	Gene:	cct5 / 322258	ZFINID:	ZDB-GENE-030131-977	Length:	541	Species:	Danio rerio

Alignment Length:	539	Identity:	386/539 - (71%)
Similarity:	478/539 - (88%)	Gaps:	1/539 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAFPGTFAFDEYGRPFIILRDQERQKRITGTDAIKTHIMAARQIASTLKTSLGPKGLDKIMVSP 65
            |||. ||.|||||||||||::||:::.|:||.:|:|:||:||:.:|:||:|||||.||||:||..
Zfish     1 MSAL-GTLAFDEYGRPFIIIKDQDKKSRLTGLEALKSHILAAKAVANTLRTSLGPNGLDKMMVDK 64

  Fly    66 DGDVTVTNDGATIMKLMEVDHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIH 130
            ||:||||||||||:.:|:|||:||||||:||:|||||||||||||||||||||||||.|:|||||
Zfish    65 DGEVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEQAEQLLDRGIH 129

  Fly   131 PIRIADGFELAAQCAIKQLDAIAQPFPVDPKNKEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVL 195
            |||||||::.||:.||:|||.|...|||||.|.|.|:|.||||||||::|:|||||||:||:|:|
Zfish   130 PIRIADGYDQAAKIAIEQLDKIGDSFPVDPNNTESLVQTAMTTLGSKVINRCHRQMAEIAVNAIL 194

  Fly   196 NVADIEKKDVNFELIKIETKVGGRMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPK 260
            .|||:|:|||:|||||:|.||||::||:.|:|||||||..||.||||.|::.|:|||||||||||
Zfish   195 TVADMERKDVDFELIKVEGKVGGKLEDTQLIKGVIVDKEFSHPQMPKVLKDTKIAILTCPFEPPK 259

  Fly   261 PKTKHKLDVTSAEDYRALREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRW 325
            |||||||||||.|||:||::||::||.:|::|||:.||.||||||||||||||||||.||||:||
Zfish   260 PKTKHKLDVTSVEDYKALQKYEKDKFQEMIRQVKENGANLAICQWGFDDEANHLLLQNELPAIRW 324

  Fly   326 VGGPEIELIAIATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRG 390
            |||||||||||||||||||||.||||||||.||||:|:.|||:||:||||||||||:|||||:||
Zfish   325 VGGPEIELIAIATGGRIVPRFCELTPEKLGTAGLVKEICFGTTKDRMLVIEECKNSRAVTIFIRG 389

  Fly   391 GNAMIIAEAKRSIHDAICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVA 455
            ||.|||.||||::|||:||:|:||:|:||||||||:||:|:|||.:.||:..:|||||.|||:.|
Zfish   390 GNKMIIEEAKRALHDALCVIRNLVRDNRIVYGGGASEIACALAVNEAADKCPSLEQYAMRAFADA 454

  Fly   456 LESIPLALAENSGLHPIETLSELKARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILL 520
            ||.||:||||||||:||:|::|::||||.|..|:||:||:....:|||..:|:|:|..|||||.|
Zfish   455 LEVIPMALAENSGLNPIQTMTEVRARQVKENNSALGIDCLHLSTNDMKQQHVIETLIGKKQQISL 519

  Fly   521 STQLVKMILKIDDVRSKNE 539
            :||:|||||||||:|...|
Zfish   520 ATQVVKMILKIDDIRGPGE 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	377/524 (72%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	356/488 (73%)
cct5	NP_997778.1	TCP1_epsilon	10..535	CDD:239455	377/524 (72%)
cct5	NP_997778.1	Cpn60_TCP1	44..533	CDD:278544	356/488 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573906
Domainoid	1	1.000	740	1.000	Domainoid score	I100
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6287
Inparanoid	1	1.050	799	1.000	Inparanoid score	I481
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0005168
OrthoInspector	1	1.000	-	-		oto39999
orthoMCL	1	0.900	-	-		OOG6_100235
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1487
SonicParanoid	1	1.000	-	-		X3688
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800