DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and Cct2

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_038934664.1	Gene:	Cct2 / 299809	RGDID:	1359143	Length:	561	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	174/517 - (33%)
Similarity:	275/517 - (53%)	Gaps:	17/517 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DQERQKRITGTDAIKTHIMAARQIASTLKTSLGPKGLDKIMVSP--DGDVTVTNDGATIMKLMEV 84
            |:||.:     .|..:..:.|..|...:|::|||||:|||::|.  |..:.||||||||:|.:.|
  Rat    43 DEERAE-----TARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGV 102

  Fly    85 DHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFELAAQCAIKQL 149
            |:..||::|.:|:.||||:|||||.|.|||..||.:||.||.:.|||..|..|:..|.:.|.:.|
  Rat   103 DNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREAL 167

  Fly   150 DAIAQPFPVDP-KNKEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNVADIEKKDVNFELIKIE 213
            .:.|.....|. |..:.|:.||.|||.||::........::||:|||.:    |...|.|.|.:.
  Rat   168 LSSAVDHGSDEVKFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRL----KGSGNLEAIHVI 228

  Fly   214 TKVGGRMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKT-KHKLDVTSAEDYRA 277
            .|:||.:.||.|.:|.::||.:..:| ||.:.|.|:.|.....:..|.|. ..::.|.|......
  Rat   229 KKLGGSLADSYLDEGFLLDKKIGVNQ-PKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAE 292

  Fly   278 LREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGPEIELIAIATGGRI 342
            :...|:||..:.|:::...|....|.:....:....|.....:.|:.......:|.:|:.|||.|
  Rat   293 IEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEI 357

  Fly   343 VPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMIIAEAKRSIHDAI 407
            ...|:.....|||...|:.|:..|  :||::........:|.||.|||....|:.||:||:|||:
  Rat   358 ASTFDHPELVKLGSCKLIEEVMIG--EDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDAL 420

  Fly   408 CVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIPLALAENSGLHPI 472
            ||:...|||.|.|||||.:|:..:.||...|.:....|..|..:|:.||..:|..:|:|:|....
  Rat   421 CVLAQTVKDPRTVYGGGCSEMLMAHAVTMLASRTPGKEAVAMESFAKALRMLPTIIADNAGYDSA 485

  Fly   473 ETLSELKARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQLVKMILKIDDV 534
            :.:::|:|.. :|.:.:.|:|.......||....:.||...|:|.:|.:.:..::||::|::
  Rat   486 DLVAQLRAAH-SEGRITAGLDMKEGSIGDMAVLGITESFQVKRQVLLSAAEAAEVILRVDNI 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	174/517 (34%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	169/492 (34%)
Cct2	XP_038934664.1	TCP1_beta	37..553	CDD:239452	174/517 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820