DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and Cct3

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_954522.1	Gene:	Cct3 / 295230	RGDID:	735038	Length:	545	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	167/532 - (31%)
Similarity:	307/532 - (57%)	Gaps:	12/532 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RPFIILRDQERQKRITGTDAIKTHIMAARQIASTLKTSLGPKGLDKIMVSPDGDVTVTNDGATIM 79
            ||.::|  .:..||.:|......:|.||:.||..::|.||||.:.|:::.|.|.:.:||||..|:
  Rat     5 RPVLVL--SQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAIL 67

  Fly    80 KLMEVDHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFELAAQC 144
            :.::|.|..||.|:::|::||:|:|||||.|::|||.:|..||..:::.:||..:...:.:|...
  Rat    68 REIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDD 132

  Fly   145 AIKQLDAIAQPFPVDPKNKEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNVADIE--KKDVNF 207
            .:..|..|:.  |||..|::.::.|..:::.:|::::.......:|:|||..|...|  :|:::.
  Rat   133 MVSTLKKIST--PVDVNNRDMMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDI 195

  Fly   208 -ELIKIETKVGGRMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKTKHKLDVTS 271
             :..::|...||.:|||.:::||:::|.::|.:|.:.::|.::.:|....|..|.:::..:::|.
  Rat   196 KKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITR 260

  Fly   272 AEDYRALREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGPEIELIAI 336
            .||:..:.:.|:|...|:.:.:......:.|.:.|..|.|.|.|::..:.|:|.|...:...||.
  Rat   261 EEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIAR 325

  Fly   337 ATGGRIVPRFEELTPEKLGV-AGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMIIAEAK 400
            |.|.|||.|.|||..:.:|. |||:.....|  .:....|.:||:.||.||.|||.:..|::|.:
  Rat   326 ACGARIVSRPEELREDDVGTGAGLLEIKKIG--DEYFTFITDCKDPKACTILLRGASKEILSEVE 388

  Fly   401 RSIHDAICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIPLALAE 465
            |::.||:.|.|:::.|.::|.||||:|::.:.|:.:::..::.:||:.:||.:.|||.||..|.:
  Rat   389 RNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQ 453

  Fly   466 NSGLHPIETLSELKARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQLVKMILK 530
            |.|...|..|:.|:|:...|...:.||:.......|||...:.|.|..|.|....:.:...::|:
  Rat   454 NCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLR 518

  Fly   531 IDDVRS--KNEG 540
            |||:.|  |.:|
  Rat   519 IDDIVSGHKKKG 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	164/524 (31%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	154/492 (31%)
Cct3	NP_954522.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		6/20 (30%)
		chap_CCT_gamma	6..529	CDD:274085	165/528 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100235
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720