DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and cct5

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_593277.1	Gene:	cct5 / 2542868	PomBaseID:	SPAC1420.02c	Length:	546	Species:	Schizosaccharomyces pombe

Alignment Length:	524	Identity:	340/524 - (64%)
Similarity:	444/524 - (84%)	Gaps:	0/524 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DEYGRPFIILRDQERQKRITGTDAIKTHIMAARQIASTLKTSLGPKGLDKIMVSPDGDVTVTNDG 75
            |:.|.|||::||||:::|:.|.||:|:||:|.:.:|:.::|||||:|||||::||||::||||||
pombe    12 DDQGNPFILVRDQEKKRRLHGIDAVKSHILATKTVANIVRTSLGPRGLDKILISPDGEITVTNDG 76

  Fly    76 ATIMKLMEVDHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFEL 140
            |||:..|||:|:||||:||||:|||||||||||||||||||||||||.|||:||||||||||:|.
pombe    77 ATILDQMEVEHQIAKLLVQLSKSQDDEIGDGTTGVVVLAGALLEQAEALIDKGIHPIRIADGYEK 141

  Fly   141 AAQCAIKQLDAIAQPFPVDPKNKEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNVADIEKKDV 205
            |.|.|:|.||||:......|:|...|.:.|.|:||||:|:|.|...|.:||||||:|||:::|||
pombe   142 ACQVAVKHLDAISDVVDFSPENTTNLFRSAKTSLGSKVVSKAHDHFANIAVDAVLSVADLQRKDV 206

  Fly   206 NFELIKIETKVGGRMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKTKHKLDVT 270
            :|||||::.||||.::|:.|||||:|||.:||.|||..:.|.|:|||||||||||||||||||:|
pombe   207 DFELIKVDGKVGGSVDDTKLVKGVVVDKDMSHPQMPHRIENAKIAILTCPFEPPKPKTKHKLDIT 271

  Fly   271 SAEDYRALREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGPEIELIA 335
            |..::.||:.||:|||.:|:|.||||||.|.||||||||||||||||..||||||||||||||||
pombe   272 SVSEFEALQAYEKEKFQEMIKHVKDAGANLVICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIA 336

  Fly   336 IATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMIIAEAK 400
            |||.||||||||:|:.:|||.||:|||::|||::||:||||:|.||:|||:|:||.|.||:.|||
pombe   337 IATNGRIVPRFEDLSSDKLGSAGIVREVSFGTTRDKILVIEKCANSRAVTVFVRGSNKMIVDEAK 401

  Fly   401 RSIHDAICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIPLALAE 465
            |::|||:||||:|::|:|:|||||||||||||||.|||:::..::||:..||:.||::|||||||
pombe   402 RALHDALCVVRNLIRDNRVVYGGGAAEISCSLAVTKEAEKIPGIDQYSMGAFADALDTIPLALAE 466

  Fly   466 NSGLHPIETLSELKARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQLVKMILK 530
            ||||..||.|:.:|||.|.|.|:.||:||:.:|.:||:...|::.|..||||:||:|||.:|:||
pombe   467 NSGLSSIEALTAVKARHVKENKAYLGIDCLQTGSNDMRKQFVIDPLIGKKQQLLLATQLCRMVLK 531

  Fly   531 IDDV 534
            ::|:
pombe   532 VNDI 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	340/524 (65%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	322/488 (66%)
cct5	NP_593277.1	TCP1_epsilon	12..537	CDD:239455	340/524 (65%)
cct5	NP_593277.1	Cpn60_TCP1	46..539	CDD:278544	323/490 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	669	1.000	Domainoid score	I15
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6287
Inparanoid	1	1.050	717	1.000	Inparanoid score	I94
OMA	1	1.010	-	-		QHG60896
OrthoFinder	1	1.000	-	-		FOG0005168
OrthoInspector	1	1.000	-	-		oto101616
orthoMCL	1	0.900	-	-		OOG6_100235
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1487
SonicParanoid	1	1.000	-	-		X3688
TreeFam	1	0.960	-	-
	14	13.860