DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and CCT5

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_036205.1	Gene:	CCT5 / 22948	HGNCID:	1618	Length:	541	Species:	Homo sapiens

Alignment Length:	534	Identity:	380/534 - (71%)
Similarity:	472/534 - (88%)	Gaps:	0/534 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GTFAFDEYGRPFIILRDQERQKRITGTDAIKTHIMAARQIASTLKTSLGPKGLDKIMVSPDGDVT 70
            ||.|||||||||:|::||:|:.|:.|.:|:|:|||||:.:|:|::|||||.||||:||..|||||
Human     5 GTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVT 69

  Fly    71 VTNDGATIMKLMEVDHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIA 135
            ||||||||:.:|:|||:||||||:||:||||||||||||||||||||||:||.|:||||||||||
Human    70 VTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIA 134

  Fly   136 DGFELAAQCAIKQLDAIAQPFPVDPKNKEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNVADI 200
            ||:|.||:.||:.||.|:....||.|:.|||||.|.||||||:||.|||||||:||:|||.|||:
Human   135 DGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADM 199

  Fly   201 EKKDVNFELIKIETKVGGRMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKTKH 265
            |::||:|||||:|.|||||:||:.|:|||||||..||.||||::.:.|:||||||||||||||||
Human   200 ERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKH 264

  Fly   266 KLDVTSAEDYRALREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGPE 330
            ||||||.|||:||::||:|||.:|::|:|:.||.||||||||||||||||||..|||||||||||
Human   265 KLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPE 329

  Fly   331 IELIAIATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMI 395
            ||||||||||||||||.|||.||||.||||:|::|||:||||||||:||||:|||||:||||.||
Human   330 IELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMI 394

  Fly   396 IAEAKRSIHDAICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIP 460
            |.|||||:|||:||:|:|::|:|:|||||||||||:|||::|||:..||||||.|||:.|||.||
Human   395 IEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIP 459

  Fly   461 LALAENSGLHPIETLSELKARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQLV 525
            :||:||||::||:|::|::||||.|...:||:||:..|.:|||..:|:|:|..|||||.|:||:|
Human   460 MALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMV 524

  Fly   526 KMILKIDDVRSKNE 539
            :|||||||:|...|
Human   525 RMILKIDDIRKPGE 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	374/524 (71%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	353/488 (72%)
CCT5	NP_036205.1	TCP1_epsilon	10..535	CDD:239455	374/524 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141033
Domainoid	1	1.000	732	1.000	Domainoid score	I104
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6287
Inparanoid	1	1.050	789	1.000	Inparanoid score	I519
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0005168
OrthoInspector	1	1.000	-	-		oto90660
orthoMCL	1	0.900	-	-		OOG6_100235
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1487
SonicParanoid	1	1.000	-	-		X3688
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800