DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and cct7

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_775355.1	Gene:	cct7 / 192324	ZFINID:	ZDB-GENE-020419-7	Length:	547	Species:	Danio rerio

Alignment Length:	540	Identity:	167/540 - (30%)
Similarity:	275/540 - (50%)	Gaps:	30/540 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PFIILRDQERQKRITGTDA------IKTHIMAARQIASTLKTSLGPKGLDKIMVSPDGDVTVTND 74
            |.|:|::        |||.      :.::|.|.:.:|..::|:|||:|:||::|...|..|::||
Zfish     5 PVILLKE--------GTDTSQGVPQLVSNINACQVVAEAVRTTLGPRGMDKLVVDNRGKATISND 61

  Fly    75 GATIMKLMEVDHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFE 139
            ||||:||::|.|..||.:|.:::|||.|:|||||.|.:||...|:|.:..::.|:||..|...|.
Zfish    62 GATILKLLDVVHPAAKTLVDIARSQDAEVGDGTTSVTLLAAEFLKQLKPYVEEGLHPQTIIRAFR 126

  Fly   140 LAAQCAIKQLDAIAQPFPVDPKNKEP--LIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNVADIEK 202
            :|.|.|:|::..||.....|.|.::.  |.:.|.|.|.||::.......::|.||||:.:.|:
Zfish   127 IATQLAVKKIKEIAVTIKKDDKQEQRRLLEKCAATALNSKLIAGQKDFFSKMVVDAVMMLDDL-- 189

  Fly   203 KDVNFELIKIETKVGGRMEDSMLVKGVIVDKTLSHS---QMPKELRNVKLAILTCPFEPPKPKTK 264
              :..::|.::...||.:|:|.||.||...||.|::   ..||...|.|:|:|....|....|..
Zfish   190 --LPLKMIGVKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKRYMNPKIALLNIELELKAEKDN 252

  Fly   265 HKLDVTSAEDYRALREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGP 329
            .::.|.|.|||:|:.:.|.......::::..:||.:.:.:....|.|......:.|.....|...
Zfish   253 AEVRVNSMEDYQAIVDAEWNILYDKLEKIHKSGAKVVLSKLPIGDVATQYFAYRNLFCAARVVEE 317

  Fly   330 EIELIAIATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAM 394
            .::...:|.||.|......||.:.||...|..|:..|  .::....:.|..:|..||.||||...
Zfish   318 NLKRTMMACGGSIQTSVGSLTDDVLGQCELFEEVQVG--GERYNFFKGCPKAKTCTIILRGGAEQ 380

  Fly   395 IIAEAKRSIHDAICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESI 459
            .:.|..||:||||.:||..:|:..||.||||.|:..|..:...:..:...:|....|::.|||.|
Zfish   381 FMEETDRSLHDAIMIVRRAIKNDSIVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEII 445

  Fly   460 PLALAENSGLHPIETLSELKARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQL 524
            |..|.:|:|......|::|:|:. |:.....|||......:|.....|.|....:...:..:::.
Zfish   446 PRQLCDNAGFDATNILNKLRAKH-AQGGMWYGVDVNNEDIADNFQACVWEPSIVRINALTAASEA 509

  Fly   525 VKMILKIDDV----RSKNEG 540
            ..:||.:|:.    ||..:|
Zfish   510 ACLILSVDETIKNPRSSVDG 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	164/534 (31%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	156/493 (32%)
cct7	NP_775355.1	chap_CCT_eta	4..525	CDD:274086	164/534 (31%)
cct7	NP_775355.1	TCP1_eta	5..525	CDD:239456	164/534 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820