DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and cct-5

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_741117.1	Gene:	cct-5 / 175588	WormBaseID:	WBGene00000380	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	369/533 - (69%)
Similarity:	467/533 - (87%)	Gaps:	2/533 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FDEYGRPFIILRDQERQKRITGTDAIKTHIMAARQIASTLKTSLGPKGLDKIMVSPDGDVTVTND 74
            |||.|:|||::|:||.||||||.:|:|:||:|||.:|:||:|||||:||||::||||||||:|||
Worm    10 FDESGQPFIVMREQENQKRITGVEAVKSHILAARAVANTLRTSLGPRGLDKMLVSPDGDVTITND 74

  Fly    75 GATIMKLMEVDHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFE 139
            |||||:.|:|.|.:|||||:||:|||.||||||||||||||||||:||.|||||||||:|||||:
Worm    75 GATIMEKMDVQHHVAKLMVELSKSQDHEIGDGTTGVVVLAGALLEEAEKLIDRGIHPIKIADGFD 139

  Fly   140 LAAQCAIKQLDAIAQPFPVDPKNKEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNVADIEKKD 204
            ||.:.|::.||:|:..|||:  |:|.|::.|.|:|||||||:..||.||:||||||:|||||.||
Worm   140 LACKKALETLDSISDKFPVE--NRERLVETAQTSLGSKIVNRSLRQFAEIAVDAVLSVADIESKD 202

  Fly   205 VNFELIKIETKVGGRMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKTKHKLDV 269
            ||||:||:|.|||||:||::||||:::|||:||.||||||:|.|:|||||||||||||||||||:
Worm   203 VNFEMIKMEGKVGGRLEDTILVKGIVIDKTMSHPQMPKELKNAKVAILTCPFEPPKPKTKHKLDI 267

  Fly   270 TSAEDYRALREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGPEIELI 334
            ||.||::|||:||:|.|..|::|||::|||||||||||||||||||...:||||||||||||||:
Worm   268 TSTEDFKALRDYERETFETMIRQVKESGATLAICQWGFDDEANHLLQANDLPAVRWVGGPEIELL 332

  Fly   335 AIATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMIIAEA 399
            ||||..||||||.||:.||||.||||||:.||.:||:||.||:|.|:||||||:||||.|||.||
Worm   333 AIATNARIVPRFSELSKEKLGTAGLVREITFGAAKDRMLSIEQCPNNKAVTIFVRGGNKMIIDEA 397

  Fly   400 KRSIHDAICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIPLALA 464
            ||::|||:||:|:||:|||||||||:||::.::.||||||::..:||||||||:.||||||:|||
Worm   398 KRALHDALCVIRNLVRDSRIVYGGGSAELAAAIQVAKEADRIDGIEQYAFRAFADALESIPMALA 462

  Fly   465 ENSGLHPIETLSELKARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQLVKMIL 529
            |||||.||:.||:|||:|:...|||||:|.:.:|.:|||...|:|:|.||::||.|:||:|:|||
Worm   463 ENSGLAPIDALSDLKAKQIETGKSSLGIDAVFAGTNDMKEQKVIETLLSKREQISLATQVVRMIL 527

  Fly   530 KIDDVRSKNEGGM 542
            ||||||..::..|
Worm   528 KIDDVRVPDDERM 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	366/524 (70%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	342/488 (70%)
cct-5	NP_741117.1	TCP1_epsilon	11..534	CDD:239455	366/524 (70%)
cct-5	NP_741117.1	Cpn60_TCP1	45..532	CDD:278544	342/488 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156270
Domainoid	1	1.000	706	1.000	Domainoid score	I50
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6287
Inparanoid	1	1.050	760	1.000	Inparanoid score	I279
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0005168
OrthoInspector	1	1.000	-	-		oto17365
orthoMCL	1	0.900	-	-		OOG6_100235
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1487
SonicParanoid	1	1.000	-	-		X3688
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940