DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and CCT2

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_006422.1	Gene:	CCT2 / 10576	HGNCID:	1615	Length:	535	Species:	Homo sapiens

Alignment Length:	517	Identity:	176/517 - (34%)
Similarity:	279/517 - (53%)	Gaps:	17/517 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DQERQKRITGTDAIKTHIMAARQIASTLKTSLGPKGLDKIMVSP--DGDVTVTNDGATIMKLMEV 84
            |:||.:     .|..|..:.|..|...:|::|||||:|||::|.  |..:.||||||||:|.:.|
Human    17 DEERAE-----TARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGV 76

  Fly    85 DHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFELAAQCAIKQL 149
            |:..||::|.:|:.||||:|||||.|.|||..||.:||.||.:.|||..|..|:..|.:.|.:.|
Human    77 DNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREAL 141

  Fly   150 DAIAQPFPVDP-KNKEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNVADIEKKDVNFELIKIE 213
            .:.|.....|. |.::.|:.||.|||.||::........::||:|||.:    |...|.|.|.|.
Human   142 LSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRL----KGSGNLEAIHII 202

  Fly   214 TKVGGRMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKT-KHKLDVTSAEDYRA 277
            .|:||.:.||.|.:|.::||.:..:| ||.:.|.|:.|.....:..|.|. ..::.|.|......
Human   203 KKLGGSLADSYLDEGFLLDKKIGVNQ-PKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAE 266

  Fly   278 LREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGPEIELIAIATGGRI 342
            :...|:||..:.|:::...|....|.:....:....|.....:.|:.......:|.:|:.|||.|
Human   267 IEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEI 331

  Fly   343 VPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMIIAEAKRSIHDAI 407
            ...|:.....|||...|:.|:..|  :||::........:|.||.|||....|:.||:||:|||:
Human   332 ASTFDHPELVKLGSCKLIEEVMIG--EDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDAL 394

  Fly   408 CVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIPLALAENSGLHPI 472
            ||:...|||||.|||||.:|:..:.||.:.|::....|..|..:::.||..:|..:|:|:|....
Human   395 CVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSA 459

  Fly   473 ETLSELKARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQLVKMILKIDDV 534
            :.:::|:|.. :|..::.|:|.......||....:.||...|:|.:|.:.:..::||::|::
Human   460 DLVAQLRAAH-SEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	176/517 (34%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	170/492 (35%)
CCT2	NP_006422.1	TCP1_beta	11..527	CDD:239452	176/517 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820