DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT5 and CCT7

DIOPT Version :9

Sequence 1:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_006420.1	Gene:	CCT7 / 10574	HGNCID:	1622	Length:	543	Species:	Homo sapiens

Alignment Length:	529	Identity:	161/529 - (30%)
Similarity:	273/529 - (51%)	Gaps:	26/529 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PFIILRDQERQKRITGTDA------IKTHIMAARQIASTLKTSLGPKGLDKIMVSPDGDVTVTND 74
            |.|:|::        |||:      :.::|.|.:.||..::|:|||:|:||::|...|..|::||
Human     5 PVILLKE--------GTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISND 61

  Fly    75 GATIMKLMEVDHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFE 139
            ||||:||::|.|..||.:|.:::|||.|:|||||.|.:||...|:|.:..::.|:||..|...|.
Human    62 GATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFR 126

  Fly   140 LAAQCAIKQLDAIAQPFPVDPK--NKEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNVADIEK 202
            .|.|.|:.::..||.......|  .::.|.:.|||.|.||::::.....|:|.||||:.:.|:
Human   127 TATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDL-- 189

  Fly   203 KDVNFELIKIETKVGGRMEDSMLVKGVIVDKTLSHS---QMPKELRNVKLAILTCPFEPPKPKTK 264
              :..::|.|:...||.:|||.||.||...||.|::   ..||:..|.|:|:|....|....|..
Human   190 --LQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDN 252

  Fly   265 HKLDVTSAEDYRALREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGP 329
            .::.|.:.|||:|:.:.|.......::::..:||.:.:.:....|.|......:::.....|...
Human   253 AEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEE 317

  Fly   330 EIELIAIATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAM 394
            :::...:|.||.|......|:.:.||...:..|...|..:.....  .|..:|..|..||||...
Human   318 DLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFT--GCPKAKTCTFILRGGAEQ 380

  Fly   395 IIAEAKRSIHDAICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESI 459
            .:.|.:||:||||.:||..:|:..:|.||||.|:..|..:...:..:...:|....|::.|||.|
Human   381 FMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEII 445

  Fly   460 PLALAENSGLHPIETLSELKARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQL 524
            |..|.:|:|......|::|:||. |:..:..|||......:|.....|.|....:...:..:::.
Human   446 PRQLCDNAGFDATNILNKLRARH-AQGGTWYGVDINNEDIADNFEAFVWEPAMVRINALTAASEA 509

  Fly   525 VKMILKIDD 533
            ..:|:.:|:
Human   510 ACLIVSVDE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	161/529 (30%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	153/494 (31%)
CCT7	NP_006420.1	TCP1_eta	5..525	CDD:239456	161/529 (30%)
CCT7	NP_006420.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..543
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820