DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prp8 and SUS2

DIOPT Version :9

Sequence 1:	NP_610735.1	Gene:	Prp8 / 36304	FlyBaseID:	FBgn0033688	Length:	2396	Species:	Drosophila melanogaster
Sequence 2:	NP_178124.2	Gene:	SUS2 / 844347	AraportID:	AT1G80070	Length:	2359	Species:	Arabidopsis thaliana

Alignment Length:	2351	Identity:	1921/2351 - (81%)
Similarity:	2143/2351 - (91%)	Gaps:	26/2351 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 IPPPGAPLPPAGGHTNGIPIPVGGQGPGLGQIPTPKPDILTEEKLQEKALKWQHLQSKRFAEKRK 110
            :|||..|.||..                    |||:.   .|.||:|||.||..|.|||:.:|||
plant    33 LPPPSNPTPPVE--------------------PTPEE---AEAKLEEKARKWMQLNSKRYGDKRK 74

  Fly   111 FGFVDTQKEDMPPEHIRKIIRDHGDMTSRKYRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRD 175
            ||||:||||||||||:||||||||||:|:|:||||||||||||::||||.||||||||||||:||
plant    75 FGFVETQKEDMPPEHVRKIIRDHGDMSSKKFRHDKRVYLGALKFVPHAVFKLLENMPMPWEQVRD 139

  Fly   176 VQVLYHITGAITFVNEIPWVIEPVYIAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD 240
            |:||||||||||||||||||:||:|:|||||||||||||||||||||||||||||||||||||||
plant   140 VKVLYHITGAITFVNEIPWVVEPIYMAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD 204

  Fly   241 NVLDVEPLEAIQIELDNDEDNAVYKWFYDHRPLVDTQFVNGTTYRKWNLSLPQLATLYRLANQLL 305
            |:|||:|||.||:|||.:||:||:.|||||:|||.|:.:||.:||:||||||.:|||:|||.|||
plant   205 NLLDVDPLEPIQLELDEEEDSAVHTWFYDHKPLVKTKLINGPSYRRWNLSLPIMATLHRLAGQLL 269

  Fly   306 TDLVDNNFFYLFDPKSFFTAKALNMAIPGGPKFEPLIKDHNVGDEDWNEFNDINKVIIRQPIRTE 370
            :||:|.|:|||||..||||||||||.||||||||||.:|...|||||||||||||:|||.|:|||
plant   270 SDLIDRNYFYLFDMPSFFTAKALNMCIPGGPKFEPLYRDMEKGDEDWNEFNDINKLIIRSPLRTE 334

  Fly   371 YRIAFPYLYNNMPHFVHLSWYHTPNVVYIKTEDPDLPAFYFDPLINPISHRNANSKIQEPLPDDD 435
            ||||||:||||.|..|.|..||:|.::|||||||||||||:||||:|||:.| ..|.:..:.||:
plant   335 YRIAFPHLYNNRPRKVKLCVYHSPMIMYIKTEDPDLPAFYYDPLIHPISNTN-KEKRERKVYDDE 398

  Fly   436 EDFTLPDDVQPFLQDTPLYTDNTANGIALLWAPRPFNMRSGRSRRAIDVPLVKCWYKEHCPPGHP 500
            :||.||:.|:|.|:||.||||.||.||:||:|||||||||||:|||.|:|||..|:||||||.:|
plant   399 DDFALPEGVEPLLRDTQLYTDTTAAGISLLFAPRPFNMRSGRTRRAEDIPLVSEWFKEHCPPAYP 463

  Fly   501 VKVRVSYQKLLKYYVLNALKHRKPKPQKKRYLFRSFKATKFFQTTTLDWVEAGLQVCRQGYNMLN 565
            ||||||||||||.||||.|.||.||.|||::||||..||||||:|.|||||.|||||||||||||
plant   464 VKVRVSYQKLLKCYVLNELHHRPPKAQKKKHLFRSLAATKFFQSTELDWVEVGLQVCRQGYNMLN 528

  Fly   566 LLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLIIDSHVQYRLNNVD 630
            |||||||||||||||||||||||||||||||||||||||||||||||||||::|::||:||.|||
plant   529 LLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDANVQFRLGNVD 593

  Fly   631 AFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPGWR 695
            ||||||||||||:|||||||||||||:|||||||||||||||||||||||||||||||||||.||
plant   594 AFQLADGLQYIFSHVGQLTGMYRYKYRLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPMWR 658

  Fly   696 VWLFFMRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMHDIVDMMPEG 760
            |||||:|||.|||||||||||:||||||||||||||||||||||||||||||:||||::|.||||
plant   659 VWLFFLRGIVPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDVLDAMPEG 723

  Fly   761 IKQNKARTILQHLSEAWRCWKANIPWKVPGLPIPIENMILRYVKMKADWWTNTAHYNRERIRRGA 825
            ||||||||||||||||||||||||||||||||:|||||||||||.|||||||.||||||||||||
plant   724 IKQNKARTILQHLSEAWRCWKANIPWKVPGLPVPIENMILRYVKSKADWWTNVAHYNRERIRRGA 788

  Fly   826 TVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYISPEEAVAIYTTTVHWLESRRFAPIPFPPL 890
            |||||||:|||||||||:|||||||||||||||||::||||:|||||||||||||:|:|||||||
plant   789 TVDKTVCRKNLGRLTRLWLKAEQERQHNYLKDGPYVTPEEALAIYTTTVHWLESRKFSPIPFPPL 853

  Fly   891 SYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVG 955
            ||||||||||||||||||:|||..||||.||||||||||||||||||||||||||||||.|||||
plant   854 SYKHDTKLLILALERLKESYSVAVRLNQQQREELGLIEQAYDNPHEALSRIKRHLLTQRGFKEVG 918

  Fly   956 IEFMDLYSHLIPVYEVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPSDTEPPPLLAYKWCQGIN 1020
            ||||||||:||||||:||||||||||||||||||.|||.|||.||||:|:||||||.||||||||
plant   919 IEFMDLYSYLIPVYEIEPLEKITDAYLDQYLWYEGDKRHLFPNWIKPADSEPPPLLVYKWCQGIN 983

  Fly  1021 NLQDVWDVGEGECNVLLESRFEKLYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHT 1085
            |||.:||.|:|:|.|:|:::|||.:||||||:|||||||::|||||||::||||||::||||:||
plant   984 NLQGIWDTGDGQCVVMLQTKFEKFFEKIDLTMLNRLLRLVLDHNIADYVSAKNNVVLSYKDMSHT 1048

  Fly  1086 NSYGIIRGLQFSSFITQYYGLVLDLLVLGLHRSSEMAGPPQMPNDFLTFQDTVTETAHPIRLYCR 1150
            ||||:||||||:||:.|:|||:||||:|||.|:||:||||||||:|:||.||..||.||||||.|
plant  1049 NSYGLIRGLQFASFVVQFYGLLLDLLLLGLTRASEIAGPPQMPNEFMTFWDTKVETRHPIRLYSR 1113

  Fly  1151 YVDRIHLFFRFSAEEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFW 1215
            |:|::|:.|:|:.|||||||||||||||||||||:||||||||||||||||||||||||||:|||
plant  1114 YIDKVHIMFKFTHEEARDLIQRYLTEHPDPNNENMVGYNNKKCWPRDARMRLMKHDVNLGRSVFW 1178

  Fly  1216 DIKNRLPRSVTTIGWESTFVSVYSKDNPNLLFNMSGFECRILPKCRTQNEEFTH-RDGVWNLQNE 1279
            |:|||||||:||:.||:.||||||||||||||:|.|||.|||||.|...|.|:: :|||||||||
plant  1179 DMKNRLPRSITTLEWENGFVSVYSKDNPNLLFSMCGFEVRILPKIRMTQEAFSNTKDGVWNLQNE 1243

  Fly  1280 ITKERTAQCFLRVDDESLGRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQEL 1344
            .||||||..|||||||.:..|.||||||||:|||||||||||||||||||||||||||.|:||||
plant  1244 QTKERTAVAFLRVDDEHMKVFENRVRQILMSSGSTTFTKIVNKWNTALIGLMTYFREATVHTQEL 1308

  Fly  1345 LDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVG 1409
            ||||||||||||||||||||||||||||||:||||||:||||||||||:||||||||:|||||||
plant  1309 LDLLVKCENKIQTRIKIGLNSKMPSRFPPVIFYTPKEIGGLGMLSMGHILIPQSDLRYSKQTDVG 1373

  Fly  1410 ITHFRSGMSHDEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEANAQNRRLTLEDLEDSWDR 1474
            :|||||||||:||||||||||||||||||||||||||||||||||||.|||||||||||||||||
plant  1374 VTHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAQAQNRRLTLEDLEDSWDR 1438

  Fly  1475 GIPRINTLFQKDRHTLAYDKGWRIRTEFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALG 1539
            |||||||||||||||||||||||:||:||||||||||||||||||||||||||||||||:|||||
plant  1439 GIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDVIQALG 1503

  Fly  1540 GVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINR 1604
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
plant  1504 GVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINR 1568

  Fly  1605 ANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETV 1669
            ||||||||||||||||||||||||||||||||||||||||||||:|||||||.||||||||||||
plant  1569 ANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVLDQELDALEIETV 1633

  Fly  1670 QKETIHPRKSYKMNSSCADILLFPAYKWNVSRPSLLADTKDTMDNTTTQKYWLDIQLRWGDYDSH 1734
            |||||||||||||||||||:|||.|:||.:|:|||:|::||..|...:.|||:|:||||||||||
plant  1634 QKETIHPRKSYKMNSSCADVLLFAAHKWPMSKPSLVAESKDMFDQKASNKYWIDVQLRWGDYDSH 1698

  Fly  1735 DVERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGCKTLIQQAMAKIMKANPA 1799
            |:|||.||||:||||||||||||||||:|.:|||||||||:||||||.|.|:.|||.||||:|||
plant  1699 DIERYTRAKFMDYTTDNMSIYPSPTGVMIGLDLAYNLHSAFGNWFPGSKPLLAQAMNKIMKSNPA 1763

  Fly  1800 LYVLRERIRKALQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPIN 1864
            ||||||||||.||||||||||||||||||||:|||||||||||||||||||||||||||||||||
plant  1764 LYVLRERIRKGLQLYSSEPTEPYLSSQNYGEIFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPIN 1828

  Fly  1865 GAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGML 1929
            ||||||||||||||||:|||||||||||||||||||||||||||:||||||||||||||||||||
plant  1829 GAIFIFNPRTGQLFLKVIHTSVWAGQKRLGQLAKWKTAEEVAALVRSLPVEEQPKQIIVTRKGML 1893

  Fly  1930 DPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFS 1994
            |||||||||||||||||||||||||||||:|||||||||||||||||||:||||||:||||||||
plant  1894 DPLEVHLLDFPNIVIKGSELQLPFQACLKIEKFGDLILKATEPQMVLFNIYDDWLKSISSYTAFS 1958

  Fly  1995 RLILILRALHVNTERTKIILKPDKTTITEAHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNV 2059
            ||||||||||||.|:.|::|||||:.:||.|||||:|||::|:||||.|:||||:||.||||||.
plant  1959 RLILILRALHVNNEKAKMLLKPDKSVVTEPHHIWPSLTDDQWMKVEVALRDLILSDYAKKNNVNT 2023

  Fly  2060 ASLTQSEIRDIILGMEISAPSAQRQQIAEIEKQTKEQNQLTATTTRTTNKHGDEIITSTTSNYET 2124
            ::||||||||||||.||:.||.|||||||||||.||.:||||.||||||.||||:|.:|||.||.
plant  2024 SALTQSEIRDIILGAEITPPSQQRQQIAEIEKQAKEASQLTAVTTRTTNVHGDELIVTTTSPYEQ 2088

  Fly  2125 QTFSSKTEWRVRAISATNLHLRTNHIYVSSDDIKETGYTYILPKNILKKFVTISDLRAQIAGYLY 2189
            ..|.|||:|||||||||||:||.|||||:||||||||||||:||||||||:.::|||.|||||||
plant  2089 SAFGSKTDWRVRAISATNLYLRVNHIYVNSDDIKETGYTYIMPKNILKKFICVADLRTQIAGYLY 2153

  Fly  2190 GVSPPDNPQVKEIRCIVMPPQWGTHQTINLPNTLPTHQYLKDMEPLGWIHTQPNELPQLSPQDIT 2254
            |:|||||||||||||:||.||||.||.::||::||.|.:|.|:|||||:||||||||||||||:|
plant  2154 GISPPDNPQVKEIRCVVMVPQWGNHQLVHLPSSLPEHDFLNDLEPLGWLHTQPNELPQLSPQDVT 2218

  Fly  2255 THAKIMQENSNWDGEKTIVITCSFTPGSCSLTAYKLTPSGFEWGSKNTDKGNNPKGYLPSHYERV 2319
            :|::|::.|..|||||.|::||||||||||||:||||.:|:|||..|.|.|:||.||||:|||:|
plant  2219 SHSRILENNKQWDGEKCIILTCSFTPGSCSLTSYKLTQTGYEWGRLNKDNGSNPHGYLPTHYEKV 2283

  Fly  2320 QMLLSNKFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHELHRTSHFLLFSNLEDGG 2384
            |||||::||||:|||....|||:|.||:|..:|||.::|.:|||||||.||.:|||.|||:|: .
plant  2284 QMLLSDRFLGFYMVPESGPWNYSFTGVKHTLSMKYSVKLGSPKEFYHEEHRPTHFLEFSNMEE-A 2347

  Fly  2385 DGAGADREDVY 2395
            |....||||.:
plant  2348 DITEGDREDTF 2358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp8	NP_610735.1	PRP8	64..2396	CDD:227505	1915/2333 (82%)
		PRO8NT	118..268	CDD:285342	128/149 (86%)
		PROCN	456..856	CDD:285343	354/399 (89%)
		RRM_4	1046..1137	CDD:287556	69/90 (77%)
		U5_2-snRNA_bdg	1270..1402	CDD:287555	116/131 (89%)
		U6-snRNA_bdg	1502..1660	CDD:287554	154/157 (98%)
		RNase_H_like_Prp8_IV	1826..2076	CDD:260013	222/249 (89%)
		MPN_PRP8	2127..2377	CDD:163687	178/249 (71%)
SUS2	NP_178124.2	PRP8	67..2359	CDD:227505	1902/2294 (83%)
		PRO8NT	82..232	CDD:285342	128/149 (86%)
		PROCN	419..819	CDD:285343	354/399 (89%)
		RRM_4	1009..1100	CDD:287556	69/90 (77%)
		U5_2-snRNA_bdg	1234..1366	CDD:287555	116/131 (89%)
		U6-snRNA_bdg	1466..1624	CDD:287554	154/157 (98%)
		RNase_H_like_Prp8_IV	1790..2040	CDD:260013	222/249 (89%)
		MPN_PRP8	2091..2341	CDD:163687	178/249 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	771	1.000	Domainoid score	I11
eggNOG	1	0.900	-	-		E1_COG5178
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4706
Inparanoid	1	1.050	2417	1.000	Inparanoid score	I1
OMA	1	1.010	-	-		QHG53611
OrthoDB	1	1.010	-	-		D156083at2759
OrthoFinder	1	1.000	-	-		FOG0004087
OrthoInspector	1	1.000	-	-		otm3155
orthoMCL	1	0.900	-	-		OOG6_101765
Panther	1	1.100	-	-	LDO	PTHR11140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2835
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840