DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prp8 and AT4G38780

DIOPT Version :9

Sequence 1:	NP_610735.1	Gene:	Prp8 / 36304	FlyBaseID:	FBgn0033688	Length:	2396	Species:	Drosophila melanogaster
Sequence 2:	NP_195589.2	Gene:	AT4G38780 / 830033	AraportID:	AT4G38780	Length:	2332	Species:	Arabidopsis thaliana

Alignment Length:	2362	Identity:	1850/2362 - (78%)
Similarity:	2085/2362 - (88%)	Gaps:	49/2362 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 IPPPG-------APLPPAGGHTNGIPIPVGGQGPGLGQIPTPKPDILTEEKLQEKALKWQHLQSK 103
            :.|||       .|..||...:...|     .......:|||:.   .|.||::||..|..|.||
plant     9 LAPPGTDGSRMQTPSHPADHPSYTAP-----SNRNTPTVPTPED---AEAKLEKKARTWMQLNSK 65

  Fly   104 RFAEKRKFGFVDTQKEDMPPEHIRKIIRDHGDMTSRKYRHDKRVYLGALKYMPHAVLKLLENMPM 168
                                       ||||||:|:|:|.||||||||||::||||.||||||||
plant    66 ---------------------------RDHGDMSSKKHRLDKRVYLGALKFVPHAVFKLLENMPM 103

  Fly   169 PWEQIRDVQVLYHITGAITFVNEIPWVIEPVYIAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEE 233
            ||||:|||:||||||||||||||:.||:||:|:||||:|||||||||||||||||||||||||||
plant   104 PWEQVRDVKVLYHITGAITFVNEVRWVVEPIYMAQWGSMWIMMRREKRDRRHFKRMRFPPFDDEE 168

  Fly   234 PPLDYADNVLDVEPLEAIQIELDNDEDNAVYKWFYDHRPLVDTQFVNGTTYRKWNLSLPQLATLY 298
            ||||||||:|||:||||||:|||.:||:|||.|||||:|||.|:.:||.:|:.||||||.::||:
plant   169 PPLDYADNLLDVDPLEAIQLELDEEEDSAVYSWFYDHKPLVKTKMINGPSYQTWNLSLPIMSTLH 233

  Fly   299 RLANQLLTDLVDNNFFYLFDPKSFFTAKALNMAIPGGPKFEPLIKDHNVGDEDWNEFNDINKVII 363
            |||.|||:||||.|:|||||..||||||||||.||||||||||.:|...|||||||||||||:||
plant   234 RLAAQLLSDLVDRNYFYLFDMPSFFTAKALNMCIPGGPKFEPLHRDMEKGDEDWNEFNDINKLII 298

  Fly   364 RQPIRTEYRIAFPYLYNNMPHFVHLSWYHTPNVVYIKTEDPDLPAFYFDPLINPISHRNANSKIQ 428
            |.|:||||::|||:||||.|..|.|..||||.|:|||||||||||||:||||:|||:.|..:|.|
plant   299 RSPLRTEYKVAFPHLYNNRPRKVKLCVYHTPMVMYIKTEDPDLPAFYYDPLIHPISNSNNTNKEQ 363

  Fly   429 EP---LPDDDEDFTLPDDVQPFLQDTPLYTDNTANGIALLWAPRPFNMRSGRSRRAIDVPLVKCW 490
            ..   ..||.:||.||:.::|.|.::|||||.||.||:||:|||||||||||:|||.|:|||..|
plant   364 RKSNGYDDDGDDFVLPEGLEPLLNNSPLYTDTTAPGISLLFAPRPFNMRSGRTRRAEDIPLVAEW 428

  Fly   491 YKEHCPPGHPVKVRVSYQKLLKYYVLNALKHRKPKPQKKRYLFRSFKATKFFQTTTLDWVEAGLQ 555
            :||||||.:|||||||||||||.|:||.|.||.||.|||::||||..||||||:|.|||||.|||
plant   429 FKEHCPPAYPVKVRVSYQKLLKCYLLNELHHRPPKAQKKKHLFRSLAATKFFQSTELDWVEVGLQ 493

  Fly   556 VCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLIIDS 620
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||::|:
plant   494 VCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDA 558

  Fly   621 HVQYRLNNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGP 685
            :||:||.|||||||||||||||:|||||||||||||:||||||||||||||||||||||||||||
plant   559 NVQFRLGNVDAFQLADGLQYIFSHVGQLTGMYRYKYRLMRQIRMCKDLKHLIYYRFNTGPVGKGP 623

  Fly   686 GCGFWAPGWRVWLFFMRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVM 750
            |||||||.|||||||:|||.|||||||||||:||||||||||||||||||||||||||||||:||
plant   624 GCGFWAPMWRVWLFFLRGIVPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVM 688

  Fly   751 HDIVDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPIPIENMILRYVKMKADWWTNTAH 815
            ||:||.||||||||||||||||||||||||||||||||||||:.||||||||||.|||||||.||
plant   689 HDVVDAMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPVAIENMILRYVKSKADWWTNVAH 753

  Fly   816 YNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYISPEEAVAIYTTTVHWLESR 880
            |||||||||||||||||:|||||||||:||||||||||:.|||||::.:|.:|||:|||:|||||
plant   754 YNRERIRRGATVDKTVCRKNLGRLTRLWLKAEQERQHNFQKDGPYVTADEGIAIYSTTVNWLESR 818

  Fly   881 RFAPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHL 945
            :|:.||||||||||||||||||||||||:||...:|||.|||||||||||||||||||.||||||
plant   819 KFSAIPFPPLSYKHDTKLLILALERLKESYSAAVKLNQQQREELGLIEQAYDNPHEALMRIKRHL 883

  Fly   946 LTQRAFKEVGIEFMDLYSHLIPVYEVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPSDTEPPPL 1010
            |||.:|||||||||||||||||||:::|||||||||||||||||.|||.|||.||||:|:|||||
plant   884 LTQHSFKEVGIEFMDLYSHLIPVYQIDPLEKITDAYLDQYLWYEGDKRHLFPNWIKPADSEPPPL 948

  Fly  1011 LAYKWCQGINNLQDVWDVGEGECNVLLESRFEKLYEKIDLTLLNRLLRLIVDHNIADYMTAKNNV 1075
            |.|||||||||||.:||..:|:|.|:|:::||||:||||||:||.||||::|..:|:|:|.||||
plant   949 LVYKWCQGINNLQGIWDTSDGQCVVMLQTKFEKLFEKIDLTVLNSLLRLVLDPKLANYVTGKNNV 1013

  Fly  1076 VINYKDMNHTNSYGIIRGLQFSSFITQYYGLVLDLLVLGLHRSSEMAGPPQMPNDFLTFQDTVTE 1140
            |::||||::||:||:||||||:||:.|:||||||||:|||.|:||:|||||.||:|:|:.||..|
plant  1014 VLSYKDMSYTNTYGLIRGLQFASFVVQFYGLVLDLLLLGLTRASEIAGPPQRPNEFMTYWDTKVE 1078

  Fly  1141 TAHPIRLYCRYVDRIHLFFRFSAEEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKH 1205
            |.||||||.||:|::|:.|:|:.|||||||||:|||.|||||||:||||||||||||||||||||
plant  1079 TRHPIRLYSRYIDKVHIMFKFTHEEARDLIQRHLTERPDPNNENMVGYNNKKCWPRDARMRLMKH 1143

  Fly  1206 DVNLGRAVFWDIKNRLPRSVTTIGWESTFVSVYSKDNPNLLFNMSGFECRILPKCRTQNEEFTH- 1269
            ||||||:||||:|||||||:||:.||:.||||||||||||||:|.|||.|:|||.|...|.|:.
plant  1144 DVNLGRSVFWDMKNRLPRSITTLEWENGFVSVYSKDNPNLLFSMCGFEVRVLPKIRMGQEAFSST 1208

  Fly  1270 RDGVWNLQNEITKERTAQCFLRVDDESLGRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYF 1334
            ||||||||||.||||||..|||.|||.:..|.||||||||:||||||||||||||||||||||||
plant  1209 RDGVWNLQNEQTKERTAVAFLRADDEHMKVFENRVRQILMSSGSTTFTKIVNKWNTALIGLMTYF 1273

  Fly  1335 REAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSD 1399
            |||.|:||||||||||||||||||:|||||||||||||||:||||||:||||||||||:||||||
plant  1274 REATVHTQELLDLLVKCENKIQTRVKIGLNSKMPSRFPPVIFYTPKEIGGLGMLSMGHILIPQSD 1338

  Fly  1400 LRWSKQTDVGITHFRSGMSHDEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEANAQNRRLT 1464
            ||:|.|||||::||||||||:||||||||||||||||||||||||||||||||||||.|||||||
plant  1339 LRYSNQTDVGVSHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAQAQNRRLT 1403

  Fly  1465 LEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRIRTEFKQYQVLKQNPFWWTHQRHDGKLWNLNN 1529
            |||||||||||||||||||||||||||||||||:||:|||||.||||||||||||||||||||||
plant  1404 LEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQALKQNPFWWTHQRHDGKLWNLNN 1468

  Fly  1530 YRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRF 1594
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
plant  1469 YRTDVIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRF 1533

  Fly  1595 TLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQ 1659
            ||||||||||||||||||||||||||:|||||||||||||||||||||||||||:|||||||.||
plant  1534 TLWWSPTINRANVYVGFQVQLDLTGIYMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVLDQ 1598

  Fly  1660 ELDALEIETVQKETIHPRKSYKMNSSCADILLFPAYKWNVSRPSLLADTKDTMDNTTTQKYWLDI 1724
            ||:.|||||||||||||||||||||||||:|||.|:||.:|:|||:|::||..|...:.|||:|:
plant  1599 ELEPLEIETVQKETIHPRKSYKMNSSCADVLLFAAHKWPMSKPSLIAESKDVFDQKASNKYWIDV 1663

  Fly  1725 QLRWGDYDSHDVERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGCKTLIQQA 1789
            |||||||||||:|||.:|||:||||||||||||||||:|.:|||||||||:||||||.|.|:.||
plant  1664 QLRWGDYDSHDIERYTKAKFMDYTTDNMSIYPSPTGVIIGLDLAYNLHSAFGNWFPGSKPLLAQA 1728

  Fly  1790 MAKIMKANPALYVLRERIRKALQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTF 1854
            |.||||:|||||||||||||.||||||||||||||||||||:|||||||||||||||||||||||
plant  1729 MNKIMKSNPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGEIFSNQIIWFVDDTNVYRVTIHKTF 1793

  Fly  1855 EGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPK 1919
            |||||||||||.||||||||||||||||||||||||||||||||||||||||||:||||||||||
plant  1794 EGNLTTKPINGVIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALVRSLPVEEQPK 1858

  Fly  1920 QIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWL 1984
            |:|||||||||||||||||||||||||||||||||||||:|||||||||||||||.|||:|||||
plant  1859 QVIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKIEKFGDLILKATEPQMALFNIYDDWL 1923

  Fly  1985 KTISSYTAFSRLILILRALHVNTERTKIILKPDKTTITEAHHIWPTLTDEEWIKVEVQLKDLILA 2049
            .|:||||||.||||||||||||.|:.|::||||.:.:||.:||||:|||::|:||||.|:||||:
plant  1924 MTVSSYTAFQRLILILRALHVNNEKAKMLLKPDMSVVTEPNHIWPSLTDDQWMKVEVALRDLILS 1988

  Fly  2050 DYGKKNNVNVASLTQSEIRDIILGMEISAPSAQRQQIAEIEKQTKEQNQLTATTTRTTNKHGDEI 2114
            ||.|||.||.::||||||||||||.||:.||.|||||||||||.||.:||||.||||||.||||:
plant  1989 DYAKKNKVNTSALTQSEIRDIILGAEITPPSQQRQQIAEIEKQAKEASQLTAVTTRTTNVHGDEL 2053

  Fly  2115 ITSTTSNYETQTFSSKTEWRVRAISATNLHLRTNHIYVSSDDIKETGYTYILPKNILKKFVTISD 2179
            |::|.|.||...|.|||:|||||||||||:||.|||||:||||||||||||:||||||||:.|:|
plant  2054 ISTTISPYEQSAFGSKTDWRVRAISATNLYLRVNHIYVNSDDIKETGYTYIMPKNILKKFICIAD 2118

  Fly  2180 LRAQIAGYLYGVSPPDNPQVKEIRCIVMPPQWGTHQTINLPNTLPTHQYLKDMEPLGWIHTQPNE 2244
            ||.||||||||:|||||||||||||:||.||.|.||.:.||::||.||:|.|:||||||||||||
plant  2119 LRTQIAGYLYGISPPDNPQVKEIRCVVMVPQCGNHQQVQLPSSLPEHQFLDDLEPLGWIHTQPNE 2183

  Fly  2245 LPQLSPQDITTHAKIMQENSNWDGEKTIVITCSFTPGSCSLTAYKLTPSGFEWGSKNTDKGNNPK 2309
            ||||||||:|.|.::::.|..||.||.|::||||||||||||:||||.:|:|||..|.|.|:||.
plant  2184 LPQLSPQDVTFHTRVLENNKQWDAEKCIILTCSFTPGSCSLTSYKLTQAGYEWGRLNKDTGSNPH 2248

  Fly  2310 GYLPSHYERVQMLLSNKFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHELHRTSHF 2374
            ||||:|||:||||||::|.||:|||....|||||||..|..::.|.|.|..|||:||::||.:||
plant  2249 GYLPTHYEKVQMLLSDRFFGFYMVPENGPWNYNFMGANHTVSINYSLTLGTPKEYYHQVHRPTHF 2313

  Fly  2375 LLFSNLEDGGDGAGADREDVYA 2396
            |.||.:|:.||   .||:|.:|
plant  2314 LQFSKMEEDGD---LDRDDSFA 2332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp8	NP_610735.1	PRP8	64..2396	CDD:227505	1843/2335 (79%)
		PRO8NT	118..268	CDD:285342	114/149 (77%)
		PROCN	456..856	CDD:285343	352/399 (88%)
		RRM_4	1046..1137	CDD:287556	61/90 (68%)
		U5_2-snRNA_bdg	1270..1402	CDD:287555	115/131 (88%)
		U6-snRNA_bdg	1502..1660	CDD:287554	152/157 (97%)
		RNase_H_like_Prp8_IV	1826..2076	CDD:260013	215/249 (86%)
		MPN_PRP8	2127..2377	CDD:163687	175/249 (70%)
AT4G38780	NP_195589.2	PRP8	47..2332	CDD:227505	1839/2317 (79%)
		PRO8NT	66..203	CDD:285342	114/136 (84%)
		PROCN	394..794	CDD:285343	352/399 (88%)
		RRM_4	984..1075	CDD:287556	61/90 (68%)
		U5_2-snRNA_bdg	1209..1341	CDD:287555	115/131 (88%)
		U6-snRNA_bdg	1441..1599	CDD:287554	152/157 (97%)
		RNase_H_like_Prp8_IV	1765..2015	CDD:260013	215/249 (86%)
		MPN_PRP8	2066..2316	CDD:163687	175/249 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	771	1.000	Domainoid score	I11
eggNOG	1	0.900	-	-		E1_COG5178
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4706
Inparanoid	1	1.050	2417	1.000	Inparanoid score	I1
OMA	1	1.010	-	-		QHG53611
OrthoDB	1	1.010	-	-		D156083at2759
OrthoFinder	1	1.000	-	-		FOG0004087
OrthoInspector	1	1.000	-	-		otm3155
orthoMCL	1	0.900	-	-		OOG6_101765
Panther	1	1.100	-	-	O	PTHR11140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2835
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840