| Sequence 1: | NP_610735.1 | Gene: | Prp8 / 36304 | FlyBaseID: | FBgn0033688 | Length: | 2396 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_006436.3 | Gene: | PRPF8 / 10594 | HGNCID: | 17340 | Length: | 2335 | Species: | Homo sapiens |
| Alignment Length: | 2331 | Identity: | 2134/2331 - (91%) |
|---|---|---|---|
| Similarity: | 2246/2331 - (96%) | Gaps: | 7/2331 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 70 QGPGLGQIP---TPKPDILTEEKLQEKALKWQHLQSKRFAEKRKFGFVDTQKEDMPPEHIRKIIR 131
Fly 132 DHGDMTSRKYRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVQVLYHITGAITFVNEIPWVI 196
Fly 197 EPVYIAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNVLDVEPLEAIQIELDNDEDN 261
Fly 262 AVYKWFYDHRPLVDT-QFVNGTTYRKWNLSLPQLATLYRLANQLLTDLVDNNFFYLFDPKSFFTA 325
Fly 326 KALNMAIPGGPKFEPLIKDHNVGDEDWNEFNDINKVIIRQPIRTEYRIAFPYLYNNMPHFVHLSW 390
Fly 391 YHTPNVVYIKTEDPDLPAFYFDPLINPISHRNANSKIQEPLPDDDEDFTLPDDVQPFLQDTPLYT 455
Fly 456 DNTANGIALLWAPRPFNMRSGRSRRAIDVPLVKCWYKEHCPPGHPVKVRVSYQKLLKYYVLNALK 520
Fly 521 HRKPKPQKKRYLFRSFKATKFFQTTTLDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLK 585
Fly 586 PVKTLTTKERKKSRFGNAFHLCREILRLTKLIIDSHVQYRLNNVDAFQLADGLQYIFAHVGQLTG 650
Fly 651 MYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPGWRVWLFFMRGITPLLERWLGNL 715
Fly 716 LSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMHDIVDMMPEGIKQNKARTILQHLSEAWRCW 780
Fly 781 KANIPWKVPGLPIPIENMILRYVKMKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLK 845
Fly 846 AEQERQHNYLKDGPYISPEEAVAIYTTTVHWLESRRFAPIPFPPLSYKHDTKLLILALERLKEAY 910
Fly 911 SVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLIPVYEVEPLE 975
Fly 976 KITDAYLDQYLWYEADKRRLFPPWIKPSDTEPPPLLAYKWCQGINNLQDVWDVGEGECNVLLESR 1040
Fly 1041 FEKLYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFSSFITQYYG 1105
Fly 1106 LVLDLLVLGLHRSSEMAGPPQMPNDFLTFQDTVTETAHPIRLYCRYVDRIHLFFRFSAEEARDLI 1170
Fly 1171 QRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTIGWESTFV 1235
Fly 1236 SVYSKDNPNLLFNMSGFECRILPKCRTQNEEFTHRDGVWNLQNEITKERTAQCFLRVDDESLGRF 1300
Fly 1301 HNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNS 1365
Fly 1366 KMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHDEDQLIPNLYR 1430
Fly 1431 YIQPWESEFIDSQRVWAEYALKRQEANAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKG 1495
Fly 1496 WRIRTEFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG 1560
Fly 1561 LFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGK 1625
Fly 1626 IPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADIL 1690
Fly 1691 LFPAYKWNVSRPSLLADTKDTMDNTTTQKYWLDIQLRWGDYDSHDVERYARAKFLDYTTDNMSIY 1755
Fly 1756 PSPTGVLIAIDLAYNLHSAYGNWFPGCKTLIQQAMAKIMKANPALYVLRERIRKALQLYSSEPTE 1820
Fly 1821 PYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTS 1885
Fly 1886 VWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQ 1950
Fly 1951 LPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNTERTKIILK 2015
Fly 2016 PDKTTITEAHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPS 2080
Fly 2081 AQRQQIAEIEKQTKEQNQLTATTTRTTNKHGDEIITSTTSNYETQTFSSKTEWRVRAISATNLHL 2145
Fly 2146 RTNHIYVSSDDIKETGYTYILPKNILKKFVTISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMPPQ 2210
Fly 2211 WGTHQTINLPNTLPTHQYLKDMEPLGWIHTQPNELPQLSPQDITTHAKIMQENSNWDGEKTIVIT 2275
Fly 2276 CSFTPGSCSLTAYKLTPSGFEWGSKNTDKGNNPKGYLPSHYERVQMLLSNKFLGFFMVPAQSSWN 2340
Fly 2341 YNFMGVRHDPNMKYELQLANPKEFYHELHRTSHFLLFSNLEDGGDGAGADREDVYA 2396 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Prp8 | NP_610735.1 | PRP8 | 64..2396 | CDD:227505 | 2132/2329 (92%) |
| PRO8NT | 118..268 | CDD:285342 | 134/149 (90%) | ||
| PROCN | 456..856 | CDD:285343 | 376/399 (94%) | ||
| RRM_4 | 1046..1137 | CDD:287556 | 85/90 (94%) | ||
| U5_2-snRNA_bdg | 1270..1402 | CDD:287555 | 127/131 (97%) | ||
| U6-snRNA_bdg | 1502..1660 | CDD:287554 | 156/157 (99%) | ||
| RNase_H_like_Prp8_IV | 1826..2076 | CDD:260013 | 244/249 (98%) | ||
| MPN_PRP8 | 2127..2377 | CDD:163687 | 222/249 (89%) | ||
| PRPF8 | NP_006436.3 | PRP8 | 1..2335 | CDD:227505 | 2132/2329 (92%) |
| Reverse transcriptase homology domain | 812..1303 | 456/490 (93%) | |||
| Linker | 1304..1577 | 267/272 (98%) | |||
| Important for branch point selection. /evidence=ECO:0000250 | 1513..1526 | 11/12 (92%) | |||
| Restriction endonuclease homology domain | 1581..1752 | 160/170 (94%) | |||
| Involved in interaction with pre-mRNA 5' splice site | 1669..2034 | 354/364 (97%) | |||
| RNase H homology domain | 1767..2020 | 247/252 (98%) | |||
| Required for interaction with EFTUD2 and SNRNP200. /evidence=ECO:0000269|PubMed:17317632 | 2301..2335 | 21/34 (62%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165151436 | |
| Domainoid | 1 | 1.000 | 815 | 1.000 | Domainoid score | I66 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H4706 | |
| Inparanoid | 1 | 1.050 | 4456 | 1.000 | Inparanoid score | I4 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S96 |
| OMA | 1 | 1.010 | - | - | QHG53611 | |
| OrthoDB | 1 | 1.010 | - | - | D156083at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0004087 | |
| OrthoInspector | 1 | 1.000 | - | - | oto90010 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_101765 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR11140 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R1384 |
| SonicParanoid | 1 | 1.000 | - | - | X2835 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 17 | 16.850 | |||||