DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8878 and VRK2

DIOPT Version :9

Sequence 1:NP_001260913.1 Gene:CG8878 / 36302 FlyBaseID:FBgn0027504 Length:1004 Species:Drosophila melanogaster
Sequence 2:NP_001123952.1 Gene:VRK2 / 7444 HGNCID:12719 Length:508 Species:Homo sapiens


Alignment Length:742 Identity:157/742 - (21%)
Similarity:247/742 - (33%) Gaps:296/742 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 YTLRPSVVNGTILRDVLSKAWRLGRPIGKGNFGEIFLASDDTVCPAS--SETAKYVVKIEPHSNG 165
            |.|......|.:|.|:....|.||:.||.|.||.|:||     .|.:  .:.|::|||:|...||
Human     9 YKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLA-----FPTNKPEKDARHVVKVEYQENG 68

  Fly   166 PLFVEIHCLINTSRNNDLSDAAEDAASLPAPQTHVLSRGPPSGIPSFIASGTHYFGDVRYRFLVL 230
            |||.|:......::.:.:....|      ..|...|      |||.|..||...|....|||:|:
Human    69 PLFSELKFYQRVAKKDCIKKWIE------RKQLDYL------GIPLFYGSGLTEFKGRSYRFMVM 121

  Fly   231 PRFDRDLHSLI-KNSRVQQKSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSKCKYLRRQVVP 294
            .|...||..:. :|...::.::|.|.:.:::|||.:|:..|.|.||||.||::            
Human   122 ERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLL------------ 174

  Fly   295 KGNGYEDHYEEKQQTTDSGNSSEQETNDDDYFLKSEKFALKKIVDIKQDEDEDDEDFDDGATSNS 359
               ||:                                                           
Human   175 ---GYK----------------------------------------------------------- 177

  Fly   360 NNSNSLDVFHTPVNKKRSARNAIQFSGSNPVRACRREKRNSMYEEMVKSHYLRPTKRISYREEFN 424
                                                                             
Human   178 ----------------------------------------------------------------- 177

  Fly   425 EDGYPKETAENSDESPESSDNESDEFIPPSSRRSVIKRGRSAQIATPKKTPVSTRASRQEKVKKE 489
                                                                             
Human   178 ----------------------------------------------------------------- 177

  Fly   490 PNGDQKLRSRGSKHLDNNPTEYKFLPTEEEHVFLIDFGLASKFQDRGVHRPFIMDQRRAHDGTLE 554
                             ||          :.|:|.|:||:.::...|.|:.:..:.|:.|:||:|
Human   178 -----------------NP----------DQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIE 215

  Fly   555 FTSRDAHLG-AHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLRQF 618
            |||.|||.| |.|||||:|.|||.:|.|..|.|||    :|..::.|  |.:...|::.:.|.|.
Human   216 FTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPW----EQNLKDPV--AVQTAKTNLLDELPQS 274

  Fly   619 YGKQVPK-----YLGEFLLQIGQLAYQERPNYERYRKIFKREYQRLGYDPCQMRLSSEEI-LRTC 677
            ..|..|.     .:.:||:....|||.|:|||:..:||.......||  |.......:.| :.|.
Human   275 VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLG--PLDFSTKGQSINVHTP 337

  Fly   678 VSTKDVVDGSKCDIFELNNKAAVNVMRNSTLSTPFQEHSLTNRVSPKN-----LRSKSNKKTTKK 737
            .|.|  ||..|....:: |||...::.....|....|...|.:|..:.     :.:::.:::|::
Human   338 NSQK--VDSQKAATKQV-NKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRR 399

  Fly   738 KFSWAEVLSQD--------PDQIARERAVKEF--EREETICP---LESRLPRRYEGKPTYA--IL 787
            :..:.|  ||:        |.:|:..:....|  ..::...|   .:||.|..|:...|.:  |.
Human   400 RQKYQE--SQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGIT 462

  Fly   788 DMEQRRREKGL--VVQEHIEEEEEDAD 812
            |:|.   ..||  .:.:....||.:||
Human   463 DLES---STGLWPTISQFTLSEETNAD 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8878NP_001260913.1 PKc_like 112..>286 CDD:304357 58/176 (33%)
SPS1 123..>284 CDD:223589 55/163 (34%)
SPS1 <491..756 CDD:223589 79/284 (28%)
PKc_like <517..652 CDD:304357 53/140 (38%)
VRK2NP_001123952.1 STKc_VRK2 16..314 CDD:271025 116/551 (21%)
SPS1 29..421 CDD:223589 135/652 (21%)
Interaction with MAP3K7. /evidence=ECO:0000269|PubMed:17709393 397..508 22/95 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1164
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D371612at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11909
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.880

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