Protein Alignment bsd and VRK2

DIOPT Version :10

• Sequence 1: NP_610733.1
• Gene: bsd / 36302
• FlyBaseID: FBgn0027504
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: NP_006287.2
• Gene: VRK2 / 7444
• HGNCID: 12719
• Length: 508
• Species: Homo sapiens
• Alignment Length: 742
• Identity: 157/742 - (21%)
• Similarity: 247/742 - (33%)
• Gaps: 296/742 - (39%)

  Fly   103 YTLRPSVVNGTILRDVLSKAWRLGRPIGKGNFGEIFLASDDTVCPAS--SETAKYVVKIEPHSNG 165
            |.|......|.:|.|:....|.||:.||.|.||.|:||     .|.:  .:.|::|||:|...||
Human     9 YKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLA-----FPTNKPEKDARHVVKVEYQENG 68

  Fly   166 PLFVEIHCLINTSRNNDLSDAAEDAASLPAPQTHVLSRGPPSGIPSFIASGTHYFGDVRYRFLVL 230
            |||.|:......::.:.:....|      ..|...|      |||.|..||...|....|||:|:
Human    69 PLFSELKFYQRVAKKDCIKKWIE------RKQLDYL------GIPLFYGSGLTEFKGRSYRFMVM 121

  Fly   231 PRFDRDLHSLI-KNSRVQQKSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSKCKYLRRQVVP 294
            .|...||..:. :|...::.::|.|.:.:::|||.:|:..|.|.||||.||::
Human   122 ERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLL------------ 174

  Fly   295 KGNGYEDHYEEKQQTTDSGNSSEQETNDDDYFLKSEKFALKKIVDIKQDEDEDDEDFDDGATSNS 359
               ||:
Human   175 ---GYK----------------------------------------------------------- 177

  Fly   360 NNSNSLDVFHTPVNKKRSARNAIQFSGSNPVRACRREKRNSMYEEMVKSHYLRPTKRISYREEFN 424
                                                                             
Human   178 ----------------------------------------------------------------- 177

  Fly   425 EDGYPKETAENSDESPESSDNESDEFIPPSSRRSVIKRGRSAQIATPKKTPVSTRASRQEKVKKE 489
                                                                             
Human   178 ----------------------------------------------------------------- 177

  Fly   490 PNGDQKLRSRGSKHLDNNPTEYKFLPTEEEHVFLIDFGLASKFQDRGVHRPFIMDQRRAHDGTLE 554
                             ||          :.|:|.|:||:.::...|.|:.:..:.|:.|:||:|
Human   178 -----------------NP----------DQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIE 215

  Fly   555 FTSRDAHLG-AHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLRQF 618
            |||.|||.| |.|||||:|.|||.:|.|..|.|||    :|..::.|  |.:...|::.:.|.|.
Human   216 FTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPW----EQNLKDPV--AVQTAKTNLLDELPQS 274

  Fly   619 YGKQVPK-----YLGEFLLQIGQLAYQERPNYERYRKIFKREYQRLGYDPCQMRLSSEEI-LRTC 677
            ..|..|.     .:.:||:....|||.|:|||:..:||.......||  |.......:.| :.|.
Human   275 VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLG--PLDFSTKGQSINVHTP 337

  Fly   678 VSTKDVVDGSKCDIFELNNKAAVNVMRNSTLSTPFQEHSLTNRVSPKN-----LRSKSNKKTTKK 737
            .|.|  ||..|....:: |||...::.....|....|...|.:|..:.     :.:::.:::|::
Human   338 NSQK--VDSQKAATKQV-NKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRR 399

  Fly   738 KFSWAEVLSQD--------PDQIARERAVKEF--EREETICP---LESRLPRRYEGKPTYA--IL 787
            :..:.|  ||:        |.:|:..:....|  ..::...|   .:||.|..|:...|.:  |.
Human   400 RQKYQE--SQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGIT 462

  Fly   788 DMEQRRREKGL--VVQEHIEEEEEDAD 812
            |:|.   ..||  .:.:....||.:||
Human   463 DLES---STGLWPTISQFTLSEETNAD 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bsd	NP_610733.1	Protein Kinases, catalytic domain	112..>286	CDD:473864	58/176 (33%)
		Protein Kinases, catalytic domain	<517..652	CDD:473864	53/140 (38%)
VRK2	NP_006287.2	STKc_VRK2	16..314	CDD:271025	116/551 (21%)
		Interaction with MAP3K7. /evidence=ECO:0000269|PubMed:17709393	397..508		22/95 (23%)