Protein Alignment CG8878 and VRK1

DIOPT Version :9

• Sequence 1: NP_001260913.1
• Gene: CG8878 / 36302
• FlyBaseID: FBgn0027504
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: XP_006720310.1
• Gene: VRK1 / 7443
• HGNCID: 12718
• Length: 420
• Species: Homo sapiens
• Alignment Length: 763
• Identity: 151/763 - (19%)
• Similarity: 230/763 - (30%)
• Gaps: 380/763 - (49%)

  Fly   112 GTILRDVLSKAWRLGRPIGKGNFGEIFLASDDTVCPASSET----AKYVVKIEPHSNGPLFVEIH 172
            |.|:.|:..|.|::|.|||:|.||.|:||..:     |||:    |..|||:||..|||||.|:.
Human    26 GEIITDMAKKEWKVGLPIGQGGFGCIYLADMN-----SSESVGSDAPCVVKVEPSDNGPLFTELK 85

  Fly   173 CLINTSRNNDLSDAAEDAASLPAPQTHVLSRG-PPSGIPSFIASGTHYFGDVRYRFLVLPRFDRD 236
            ..             :.||.....|..:.:|. ...|:|.:..||.|......|||:::.||..|
Human    86 FY-------------QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD 137

  Fly   237 LHSLIKNS--RVQQKSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSKCKYLRRQVVPKGNGY 299
            |..:.:.:  |..:|::|.|::.|:::||.:|:..|.|.||||.||:
Human   138 LQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLL------------------ 184

  Fly   300 EDHYEEKQQTTDSGNSSEQETNDDDYFLKSEKFALKKIVDIKQDEDEDDEDFDDGATSNSNNSNS 364
                                                                             
Human   185 ----------------------------------------------------------------- 184

  Fly   365 LDVFHTPVNKKRSARNAIQFSGSNPVRACRREKRNSMYEEMVKSHYLRPTKRISYREEFNEDGYP 429
                                                                ::|:
Human   185 ----------------------------------------------------LNYK--------- 188

  Fly   430 KETAENSDESPESSDNESDEFIPPSSRRSVIKRGRSAQIATPKKTPVSTRASRQEKVKKEPNGDQ 494
                                                                             
Human   189 ----------------------------------------------------------------- 188

  Fly   495 KLRSRGSKHLDNNPTEYKFLPTEEEHVFLIDFGLASKFQDRGVHRPFIMDQRRAHDGTLEFTSRD 559
                        ||          :.|:|:|:|||.::...|||:.:..|.:|.||||:||||.|
Human   189 ------------NP----------DQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSID 231

  Fly   560 AHLG-AHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEML-RQFYGKQ 622
            ||.| |.|||.|||.|||.::.|..|:|||:|  ..:..:.|..:|..:..::..:: :.|..|.
Human   232 AHNGVAPSRRGDLEILGYCMIQWLTGHLPWED--NLKDPKYVRDSKIRYRENIASLMDKCFPEKN 294

  Fly   623 VPKYLGEFLLQIGQLAYQERPNYERYRKIFKREYQRLGYDPCQMRLSSEEILRTCVSTKDVVDGS 687
            .|..:.:::..:..|.|.|:|.||..|.|..:..:.:|                   :||  ||
Human   295 KPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIG-------------------SKD--DG- 337

  Fly   688 KCDIFELNNKAAVNVMRNSTLSTPFQEHSLTNRVSPKNLRSKSNKKTTKKKFSWAEVLSQDPDQI 752
                     |..::|:.|..|..                      ||..||
Human   338 ---------KLDLSVVENGGLKA----------------------KTITKK-------------- 357

  Fly   753 ARERAVKEFEREETICPLESRLPRRYEGKPTYAILDMEQRRREKGLVVQEHIEEEEEDADEDDEE 817
                                                   |::|        |||.:|...||.|.
Human   358 ---------------------------------------RKKE--------IEESKEPGVEDTEW 375

  Fly   818 ENQEAMDIDQEEDGEAADSAEGEDESDRSMEGSDCSDHSQKRARGRPK 865
            .|      .|.|:.....|.|.:....|||...:.|..|...:|.|.:
Human   376 SN------TQTEEAIQTRSEESQGAIHRSMSQPEASSSSYDSSRTRKR 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8878	NP_001260913.1	PKc_like	112..>286	CDD:304357	62/180 (34%)
		SPS1	123..>284	CDD:223589	58/167 (35%)
		SPS1	<491..756	CDD:223589	67/266 (25%)
		PKc_like	<517..652	CDD:304357	51/136 (38%)
VRK1	XP_006720310.1	STKc_VRK1	26..326	CDD:271024	117/550 (21%)
		S_TKc	37..293	CDD:214567	103/506 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D371612at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880