DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8878 and Vrk2

DIOPT Version :9

Sequence 1:	NP_001260913.1	Gene:	CG8878 / 36302	FlyBaseID:	FBgn0027504	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_081536.2	Gene:	Vrk2 / 69922	MGIID:	1917172	Length:	503	Species:	Mus musculus

Alignment Length:	738	Identity:	160/738 - (21%)
Similarity:	241/738 - (32%)	Gaps:	302/738 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 YTLRPSVVNGTILRDVLSKAWRLGRPIGKGNFGEIFLASDDTVCPAS--SETAKYVVKIEPHSNG 165
            |.|...:..|.||.|:....|.||:.||.|.||.|:||     .|.:  ::.|::|:|:|...||
Mouse     9 YKLPVPLPEGKILDDMEGNRWALGKMIGSGGFGLIYLA-----FPTNKPNKDARHVIKLEYQENG 68

  Fly   166 PLFVEIHCLINTSRNNDLSDAAEDAASLPAPQTHVLSRG-PPSGIPSFIASGTHYFGDVRYRFLV 229
            |||.|:...             :.||.....|..:..|. ...|||.|...|...|....|||:|
Mouse    69 PLFSELKFY-------------QRAAKRECIQKWIQQRKLDYLGIPVFYGFGLTDFKGRSYRFMV 120

  Fly   230 LPRFDRDLHSLI-KNSRVQQKSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSKCKYLRRQVV 293
            :.|...||..|: :|...::.::|.|.:.:::|||.:|:..|.|.||||.||::
Mouse   121 MERLGIDLQKLLDQNGGFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLL----------- 174

  Fly   294 PKGNGYEDHYEEKQQTTDSGNSSEQETNDDDYFLKSEKFALKKIVDIKQDEDEDDEDFDDGATSN 358
                                                                    ||
Mouse   175 --------------------------------------------------------DF------- 176

  Fly   359 SNNSNSLDVFHTPVNKKRSARNAIQFSGSNPVRACRREKRNSMYEEMVKSHYLRPTKRISYREEF 423
                                        :||
Mouse   177 ----------------------------TNP---------------------------------- 179

  Fly   424 NEDGYPKETAENSDESPESSDNESDEFIPPSSRRSVIKRGRSAQIATPKKTPVSTRASRQEKVKK 488

Mouse   180 ----------------------------------------------------------------- 179

  Fly   489 EPNGDQKLRSRGSKHLDNNPTEYKFLPTEEEHVFLIDFGLASKFQDRGVHRPFIMDQRRAHDGTL 553
                                          :.|:|.|:||:.::...|.|:.:..|.|:.|:||:
Mouse   180 ------------------------------DRVYLADYGLSYRYCPNGNHKQYQEDPRKGHNGTI 214

  Fly   554 EFTSRDAHLG-AHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLRQ 617
            ||||.|||.| |.|||||:|.|||.:|:|..|.|||:  |:......|..||...:.::||.:.
Mouse   215 EFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWE--AKLDDPVAVQTAKTNLLDELPESVL- 276

  Fly   618 FYGKQVP-----KYLGEFLLQIGQLAYQERPNYERYRKIFKREYQRLGYDPCQMRLSSEEI-LRT 676
               |..|     ..|.::|:.:..|||.::|:|::.:||...:...||  |.:.....:.: :||
Mouse   277 ---KWAPSGSSCSELVKYLMYVHNLAYDDKPDYQKLKKILNPDGVPLG--PLEFSTKVQSVHVRT 336

  Fly   677 CVSTKDVVDGSKCDIFELNN---KAAVNVMRNS-TLSTPFQEHSLTNRVSPKNLRSK----SNKK 733
            ....|  ||..|......|.   |....|.|.: ......||.|     .|..|:|:    .|.:
Mouse   337 PAQQK--VDSPKATRKPANEFPAKFPKKVHRETRARQREEQEDS-----QPTMLQSRPAAPENSR 394

  Fly   734 TTK-----KKFSWAEVLSQDPDQIARE----RAVKEFEREETICPLESRLPR---RYEGKPT--Y 784
            |.|     ..||..:.|.|.|..::.:    :...:..|.:.|     |.||   ||...||  .
Mouse   395 TRKIHEYSDIFSEMQSLQQTPSYMSFQGSYCKPYLDCTRRDPI-----RKPRSLPRYRHTPTGNL 454

  Fly   785 AILDMEQRRREKGLVVQEHIEEE 807
            .:.|:|...|....:.|..:.||
Mouse   455 GVTDLESSPRFWPAIFQLTLSEE 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8878	NP_001260913.1	PKc_like	112..>286	CDD:304357	59/177 (33%)
		SPS1	123..>284	CDD:223589	55/164 (34%)
		SPS1	<491..756	CDD:223589	80/288 (28%)
		PKc_like	<517..652	CDD:304357	52/140 (37%)
Vrk2	NP_081536.2	PKc_like	16..314	CDD:389743	116/552 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..353		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..395		9/37 (24%)
		Interaction with MAP3K7. /evidence=ECO:0000250	392..503		23/91 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D371612at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880