DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8878 and vrk1

DIOPT Version :9

Sequence 1:	NP_001260913.1	Gene:	CG8878 / 36302	FlyBaseID:	FBgn0027504	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_998550.1	Gene:	vrk1 / 406694	ZFINID:	ZDB-GENE-040426-2709	Length:	425	Species:	Danio rerio

Alignment Length:	668	Identity:	139/668 - (20%)
Similarity:	222/668 - (33%)	Gaps:	295/668 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 NGTILRDVLSKAWRLGRPIGKGNFGEIFLASDDTVCPASSETAKYVVKIEPHSNGPLFVEIHCLI 175
            :|.:|.|...|.|:||..:|:|.||.::||::|:..|.::: |.||:|:||..|||||.|:...:
Zfish    26 SGEVLTDNAKKKWKLGSAVGQGGFGLLYLANEDSSGPVTAD-APYVIKVEPSDNGPLFSELKFYM 89

  Fly   176 NTSRNNDLSDAAEDAASLPAPQTHVLSRGPPSGIPSFIASGTHYFGDVRYRFLVLPRFDRDLHSL 240
            ..::.:.:      .|.:.:.:...|      |:|.:..||.|.....||||:|:.||..||..|
Zfish    90 RAAKPDLI------GAWMKSKKMEYL------GVPKYWGSGFHEKNGKRYRFMVMDRFGTDLQKL 142

  Fly   241 IKNS--RVQQKSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSKCKYLRRQVVPKGNGYEDHY 303
            .:.:  :..:|.:|.|.:.::::||.:||..|.|.||||.||::|
Zfish   143 FEGNGKKFSRKLVLQLGLRLLDILEYIHDHEYVHADIKASNLLLS-------------------- 187

  Fly   304 EEKQQTTDSGNSSEQETNDDDYFLKSEKFALKKIVDIKQDEDEDDEDFDDGATSNSNNSNSLDVF 368

Zfish   188 ----------------------------------------------------------------- 187

  Fly   369 HTPVNKKRSARNAIQFSGSNPVRACRREKRNSMYEEMVKSHYLRPTKRISYREEFNEDGYPKETA 433
                                                     |..|.:
Zfish   188 -----------------------------------------YTNPNQ------------------ 193

  Fly   434 ENSDESPESSDNESDEFIPPSSRRSVIKRGRSAQIATPKKTPVSTRASRQEKVKKEPNGDQKLRS 498

Zfish   194 ----------------------------------------------------------------- 193

  Fly   499 RGSKHLDNNPTEYKFLPTEEEHVFLIDFGLASKFQDRGVHRPFIMDQRRAHDGTLEFTSRDAHLG 563
                                  |||:|:|||.::...||.:.:..|.:|.||||:||||.|||.|
Zfish   194 ----------------------VFLVDYGLAYRYAPEGVPKEYKEDPKRCHDGTIEFTSIDAHKG 236

  Fly   564 -AHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLRQ-FYGKQVPKY 626
             :.|||:|||.:||.::.|....|||:|  :.|....|..:|.....::.|.|:. |....:|..
Zfish   237 VSPSRRADLEIMGYCMIQWLCSRLPWED--KLQDPLYVRDSKLRCRDNIDEFLKSCFASGNIPAE 299

  Fly   627 LGEFLLQIGQLAYQERPNYERYRKIFKREYQRLGYDPCQMRLSSEEILRTCVSTKDVVDGSKCDI 691
            :|:|:.::..|.|.:||:|::.|.|.::..:.:|                  ||.|
Zfish   300 MGKFMQEVKVLGYTDRPDYDKLRGILQQGLKSIG------------------STDD--------- 337

  Fly   692 FELNNKAAVNVMRNST----LSTP--------FQEHSLTNRVSPKNLRSKSNKKT--TKKKFSWA 742
                .|....|..|||    :.||        .|....|:....|..|:...|:.  .||..|.|
Zfish   338 ----KKLDFGVATNSTSLPSVKTPKRKKAEEKGQSADETDSTPAKKRRAPQKKEVNGAKKTASPA 398

  Fly   743 EVLSQDPDQIARERAVKE 760
            :...:...|.:.|.|||:
Zfish   399 KRPVKKETQASSEPAVKK 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8878	NP_001260913.1	PKc_like	112..>286	CDD:304357	60/175 (34%)
		SPS1	123..>284	CDD:223589	55/162 (34%)
		SPS1	<491..756	CDD:223589	73/280 (26%)
		PKc_like	<517..652	CDD:304357	51/136 (38%)
vrk1	NP_998550.1	PKc_like	27..327	CDD:304357	114/545 (21%)
		SPS1	37..>265	CDD:223589	94/473 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..425		20/74 (27%)
		GAGA_bind	<373..>424	CDD:283799	12/44 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D371612at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.880