DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8878 and Ttbk2

DIOPT Version :9

Sequence 1:	NP_001260913.1	Gene:	CG8878 / 36302	FlyBaseID:	FBgn0027504	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_006234899.2	Gene:	Ttbk2 / 311349	RGDID:	1311661	Length:	1311	Species:	Rattus norvegicus

Alignment Length:	731	Identity:	141/731 - (19%)
Similarity:	239/731 - (32%)	Gaps:	283/731 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 QKLRSRGSKHLDNNPTEYKF--LPTEEEHVFLIDFGLASKFQDR-GVHRPFIMDQRRA---HDGT 552
            :.:.|.|..|.|..|:.:..  .|:.....|::|||||.:|.:. |..||     .||   ..||
  Rat   199 ESIHSVGFLHRDIKPSNFAMGRFPSTCRKCFMLDFGLARQFTNSCGDVRP-----PRAVAGFRGT 258

  Fly   553 LEFTSRDAH----LGAHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPE 613
            :.:.|.:||    :|.|   .||..|.|.|:.:..|.|||:.:   :.:|:|...||.:  |...
  Rat   259 VRYASINAHRNREMGRH---DDLWSLFYMLVEFVVGQLPWRKI---KDKEQVGSIKERY--DHRL 315

  Fly   614 MLRQFYGKQVPKYLGEFLLQIGQLAYQERPNYERYRKIFKREYQRLGY---DPCQMRLSSEEILR 675
            ||     |.:|.....||..|..|.|..:|:|:....:|....:..|.   ||.....|..:...
  Rat   316 ML-----KHLPPEFSTFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKSGTDGSL 375

  Fly   676 TCVSTKDVVDGSKCDIFELNNK---AAVNV----------MRNSTLSTPFQEHSLTN-------R 720
            |..:|....        :|:.:   ||:.:          :|.:| ...|.:..|::       .
  Rat   376 TTTTTSATP--------QLHTRLTPAAIGIANATPIPGDLLRENT-DEVFPDEQLSDGENGIPAG 431

  Fly   721 VSPKNLRSKSNKKTTKKKFSWAE----------------------------------------VL 745
            |||..|.........::|..|.|                                        |.
  Rat   432 VSPDKLPGSLGHPRPQEKDVWEEMDINKNKIKLGICKAATEEENSHGQVNGILNAPSLGSPIRVR 496

  Fly   746 SQ--DPDQ----IARERAVKEFEREETICPLESRLPRRYEGKP-TYAILD--MEQRRREKGLVVQ 801
            |:  .||:    :.:.|::..||       ||.||  ..|.|| |...|:  ||:.:::.....:
  Rat   497 SEITQPDRDVPLVRKLRSIHSFE-------LEKRL--TLEPKPDTDKFLETCMEKMQKDSSAGKE 552

  Fly   802 E---------------------HIEEE-------------EEDADE--------------DDEEE 818
            .                     |.:||             .|.||.              ..|.:
  Rat   553 PVLPALPHKPCVPAVPRTDHVWHYDEEYPPDASKPASANTPEQADGGGSHGFIAVNLSSCKQEVD 617

  Fly   819 NQEAMDIDQEED----------GEAADSAEGEDESD--RSMEGSDCSD-----------HSQKRA 860
            ::|.:.:|:|:|          |.....:..::|.:  :.:|||...:           |.:|.:
  Rat   618 SKEWVIVDKEQDLRDFRTNEVLGHKTTGSPSDEEPEVLQVLEGSPQDEKIQVGPWTDNQHLKKES 682

  Fly   861 RGRPKGTSRKQTTSRQAQPHQNQPPVKVHRGVGRPGKNSGVVKLAAGAVSKNRT-TPLSAVASNK 924
            .|.....|.:...:..::.:.::                  :.|.|||.|:..| ||.|.:.:..
  Rat   683 SGVILALSAECPATAASELYTDR------------------LDLQAGAASQFITVTPTSPMEAQA 729

  Fly   925 RGCAT------------------------------------------RKENSTLASATGE----G 943
            .|..|                                          |:..|.||...||    |
  Rat   730 EGPLTAITIPRPSVASTQSTSGSFHYGPQPEKKDLQPLEPTVELFSPRENFSGLAVTEGELGSGG 794

  Fly   944 ER----------------KLKSGRTRRALYKTEPKHGEHDAENNSSLLV--VQNLYGEYDDEN-- 988
            .|                .:|.|...:.|       |..|..:::.|:|  .:||.||.::::
  Rat   795 SRVDLGLQIDHIGHGMLPNMKDGDASQDL-------GPRDLPDSNRLVVKEFENLPGETEEKSIL 852

  Fly   989 --NYGKGRSVHSSRHC 1002
              :..:...::..:||
  Rat   853 LGSDNEDEKLNKGQHC 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8878	NP_001260913.1	PKc_like	112..>286	CDD:304357
		SPS1	123..>284	CDD:223589
		SPS1	<491..756	CDD:223589	75/340 (22%)
		PKc_like	<517..652	CDD:304357	44/142 (31%)
Ttbk2	XP_006234899.2	STKc_TTBK2	89..350	CDD:271031	50/168 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900