DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8878 and K09C6.2

DIOPT Version :9

Sequence 1:	NP_001260913.1	Gene:	CG8878 / 36302	FlyBaseID:	FBgn0027504	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_503344.2	Gene:	K09C6.2 / 187199	WormBaseID:	WBGene00019556	Length:	634	Species:	Caenorhabditis elegans

Alignment Length:	652	Identity:	145/652 - (22%)
Similarity:	226/652 - (34%)	Gaps:	211/652 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 YLRPTKRISYREEFNEDGYPKETAENSDESPESSDNESDEFIPPSSRRSVIKRGRSAQIATPKKT 474
            :|:.|| ....||.:.||           .||||.:.|::|....|.||...  |||::|: :|.
Worm     4 FLKKTK-YEMMEELDPDG-----------PPESSSSTSNQFWLVQSIRSGCM--RSAKLAS-QKN 53

  Fly   475 PVSTRASRQEKVKKEPNGDQKLRSRGSKHLDNNPTEYKFLPT---EEEHVFLI--DFGL--ASKF 532
            |      ...:::|:.|..:||.......| :||:....|..   :::..|||  |||:  .:.|
Worm    54 P------EHLQLQKDLNKQRKLLFDLLPEL-SNPSHIARLVDVGYDDDFKFLIFEDFGMDFLTLF 111

  Fly   533 QDRG---------------------------VH---RP--FIMDQRRAHDGTLEFT--SR----- 558
            .:.|                           ||   ||  |.::|   |...::.|  ||
Worm   112 DEFGPVLNPATLFLISYFTFNAIKELHSFDIVHLDIRPSSFSVNQ---HPFNIKITDYSRCMTRK 173

  Fly   559 -------DAHLGAHSRR------------SDLECLGYNLLY-WSEGYLPWKDVAQQQQQEKVHRA 603
                   ||...:.|.|            .|.|...|.:|: .:...|||...|     |.:.|.
Worm   174 PEMKVPDDARPDSFSPRVFHQKDAQFDEFVDFEAWVYTMLFLCTVEKLPWFGDA-----ENMLRL 233

  Fly   604 KELFMTDVPEMLRQFYGKQVPKYLG--EFLLQIGQLAYQERPNYERYRK----IFKREYQRLGYD 662
            ||.|..|....|          |.|  :|:..:......::..|:.:.:    ||..:..:.. |
Worm   234 KEEFFNDPLNYL----------YDGCADFVPLVACFIADKKLTYDTFMEEMNLIFSVDVMQYS-D 287

  Fly   663 PCQMRLSSEEILRTCVSTKDVVDGSKCDIFELNNKAAVNVMRNSTLSTPFQEHSLTNRVSPKNLR 727
            ..|.||.:.:.|.....|:...|      |..||  |:::..:...:....:|.        |||
Worm   288 KEQPRLYTMKELEEVKKTRRAPD------FYTNN--AIDIAESHWHAADDSDHD--------NLR 336

  Fly   728 S----KSNKKTTKKKFSWAEVLSQDPDQIARERAVKEFEREETICPLESRLPRRYEGKPTYAILD 788
            :    ...|..|||            |...|..|......|:|..|:..........||..|...
Worm   337 TSDEENEQKSETKK------------DSCERSSAEVSSSTEQTSAPMSEASSSDGRKKPKNAGKS 389

  Fly   789 MEQRRREKGLVVQEHIEEEEEDADEDDEEENQEAMDIDQEEDGEAADSAEGEDESDRSMEGSDCS 853
            .|:    ||...:::...|::|                   || |.:...|   .:|....||..
Worm   390 AER----KGKPAEKNPSSEKDD-------------------DG-ATEPMSG---VERRSTPSDVV 427

  Fly   854 DHSQKRARGRPKGTSRKQTTSRQAQPHQNQ------PPVKVHRGVGRPGKNSGVVKLAAGAVSK- 911
            :.     :||.||...||...|:....:.|      ||..      :|||..   |::.|.:::
Worm   428 NE-----KGRVKGDPEKQKQDRKENKTEEQNSKISAPPKP------KPGKGK---KVSRGLITRE 478

  Fly   912 -------NRTTPLSAVASNKRGCATRKENSTLAS--ATGEGERKLKSGRTRRALYKTEPKHGEHD 967
                   :.|.|.||:..:....:....::..:|  ||.|||.|.|        :|...| .|.|
Worm   479 FLLGMRQDLTGPQSAMTGSYDSTSATSLSTWTSSTCATDEGEEKRK--------FKWSLK-SEED 534

  Fly   968 AE 969
            :|
Worm   535 SE 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8878	NP_001260913.1	PKc_like	112..>286	CDD:304357
		SPS1	123..>284	CDD:223589
		SPS1	<491..756	CDD:223589	71/340 (21%)
		PKc_like	<517..652	CDD:304357	41/203 (20%)
K09C6.2	NP_503344.2	SPS1	72..>224	CDD:223589	32/155 (21%)
K09C6.2	NP_503344.2	PTZ00121	<270..>455	CDD:173412	50/245 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900