DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8878 and ttbk-3

DIOPT Version :9

Sequence 1:	NP_001260913.1	Gene:	CG8878 / 36302	FlyBaseID:	FBgn0027504	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_501778.4	Gene:	ttbk-3 / 185199	WormBaseID:	WBGene00009324	Length:	562	Species:	Caenorhabditis elegans

Alignment Length:	378	Identity:	89/378 - (23%)
Similarity:	158/378 - (41%)	Gaps:	80/378 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 LRSRGSKHLDNNPTEYKFLPTEEEH----VFLIDFGLASKF---QDRGVH-RPFIMDQRRAHDGT 552
            :..:|..|.|..|........::..    |.:|||||..::   :::..: ||  :..:....|:
Worm   200 MHEKGFIHRDIKPENLLMGAADDRKRSRIVHVIDFGLTRQWAWSKEKAFYARP--LRTKVQFRGS 262

  Fly   553 LEFTSRDAHLGAH-SRRSDLECLGYNLLYWSEGYLPW---KD---VAQQQQQEKVHRAKELFMTD 610
            |.|||.:||||.. .|:.||..|.:.|:..:: .|||   ||   :|:|:....|...|
Worm   263 LNFTSSNAHLGYKLGRKDDLWSLLFTLVDLND-RLPWHGVKDHMILARQKMNMGVALMK------ 320

  Fly   611 VPEMLRQFYGKQVPKYLGEFLLQIGQLAYQERPNYERYRKIFKREYQRLGYD-PC------QMRL 668
            :|:.:.:|:         |.||:...|   :||||.....|.| ..|.|..| |.      ::.|
Worm   321 MPKTMERFF---------EHLLECRAL---QRPNYHMMFNILK-GIQSLSEDTPTSKYTFEEVEL 372

  Fly   669 SSEEILRTCVSTKDVVDGS--KCDIFELNN-----KAA-------VNVMRNSTLSTPFQEHSLTN 719
            |.:::........:.|.|.  ..|..::||     |.|       |:|.::::.:....:..|:.
Worm   373 SEDDLEERFTGEWEEVTGEFFAIDEVKINNPEKCSKLASEWKNPDVDVFQSASKNQKGSKMMLSY 437

  Fly   720 --RVSPKN--LRSKSNKKTTKKKFSWAEVLSQDPDQIARERAVKEFEREETICPLESRLPRRYEG 780
              |::.||  ...|:.:|..:..:.|.:         ||||    :.:......|..|..:::|.
Worm   438 EFRLTGKNEEQTGKNEEKMNEYAYRWEK---------ARER----YRQRMLRLKLNDRNKQQFEA 489

  Fly   781 KPTYAILDMEQRRREK----GLVVQEHIEEEEEDADEDDEEENQEAMDIDQEE 829
            | .|....:|..||::    ..|..:::..|..::||.|.|.|...:..|:.:
Worm   490 K-NYMEQQIENDRRDRLDDIENVALKYLTTEGANSDEKDAEVNMSELHKDRND 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8878	NP_001260913.1	PKc_like	112..>286	CDD:304357
		SPS1	123..>284	CDD:223589
		SPS1	<491..756	CDD:223589	71/299 (24%)
		PKc_like	<517..652	CDD:304357	41/149 (28%)
ttbk-3	NP_501778.4	PKc_like	86..351	CDD:389743	46/171 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900