DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8878 and kin-35

DIOPT Version :9

Sequence 1:	NP_001260913.1	Gene:	CG8878 / 36302	FlyBaseID:	FBgn0027504	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_491444.3	Gene:	kin-35 / 172091	WormBaseID:	WBGene00019769	Length:	439	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	85/464 - (18%)
Similarity:	160/464 - (34%)	Gaps:	136/464 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 RPVYTLRPSVVNGTILRDVLSKAWRLGRPIGKGNFGEIFLASDDTVCPASSETAKYVVKIEPHSN 164
            |.|.::|.::....:.......||...|.:|:|.||.::..|:      .|...:..:|||..:.
Worm    10 RQVESIRLNIGEEVVEEKSGKLAWLTIRELGRGAFGTVYHVSN------KSTKQEAALKIERMTA 68

  Fly   165 GPLFVEIHCLINTSRNNDLSDAAEDAASLPAPQTHVLSRGPPSGIPSFIASGTHYFGD---VRYR 226
            |...::|...|..:..::                       |:.|        |.:.|   ..||
Worm    69 GDNLLKIEREIMVAMQHE-----------------------PTAI--------HIYDDGIYKDYR 102

  Fly   227 FLVLPRFDRDLHSL--IKNSRVQQKSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMV-----SK 284
            ::|:.....||..:  :.|:...|.:::.:.:..:..::.:|:..|.|.|:|..|..|     |.
Worm   103 YIVMTLCGPDLQKIAELMNNNFNQDTIIRVCIRTLLAIKTMHEYTYIHRDLKPCNFAVDFNPNSL 167

  Fly   285 CKYLRRQVVPKGNGYEDHYEEKQQTTDSGN-------------------------SSEQETNDDD 324
            ..||          ::.....|..|.||||                         ..::.:..||
Worm   168 HVYL----------FDYGMARKYATKDSGNKWQLRRPRNPAQFRGTVRYCSLNMHKRKELSRVDD 222

  Fly   325 ----YFLKSEKFA---------LKKIVDIKQDEDEDDEDFDDGATSNSNNSNSLDVFHTPVNKKR 376
                :|:..|.:|         .::|..:|:|              :.|...|.|.|.:......
Worm   223 LWSWFFMLMEMYAPLPWTSSNIPERIEALKED--------------HLNEYLSKDSFLSSFLPLV 273

  Fly   377 SARNAIQFSGSNP-------VRACRREKRNSMYEEMVKSHYLRPTKRISYREEFNEDGYPKETAE 434
            ...|::|:: ..|       :...:..:.|......:|....|....::   |..|...|||.:.
Worm   274 EYLNSVQYA-DRPDYMKIYDILYAKLTEINGKLSGPMKYDVARINALVA---ELGETARPKELSR 334

  Fly   435 NSDESPESSDNESDEFIPPSSRRSVIKRGRSAQIAT-----PKKTPVSTRASRQEKV---KKEPN 491
            ..|||      ...:::..|..|:.:..|.:..:|.     .|..|:  :.:|:||.   ||:.|
Worm   335 MDDES------TIQKYLLASFGRAGVPGGNNLIMAELVDFFAKDVPL--KKAREEKTDDNKKQKN 391

  Fly   492 GDQKLRSRG 500
            ...|.:..|
Worm   392 AKVKNKMLG 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8878	NP_001260913.1	PKc_like	112..>286	CDD:304357	34/183 (19%)
		SPS1	123..>284	CDD:223589	32/170 (19%)
		SPS1	<491..756	CDD:223589	3/10 (30%)
		PKc_like	<517..652	CDD:304357
kin-35	NP_491444.3	PKc_like	33..294	CDD:389743	56/322 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900