DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8878 and TTBK2

DIOPT Version :9

Sequence 1:	NP_001260913.1	Gene:	CG8878 / 36302	FlyBaseID:	FBgn0027504	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_005254228.1	Gene:	TTBK2 / 146057	HGNCID:	19141	Length:	1250	Species:	Homo sapiens

Alignment Length:	807	Identity:	160/807 - (19%)
Similarity:	264/807 - (32%)	Gaps:	296/807 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 GYPKETAENSDESPESSDNESDEFIPPSSR---RSVIKRGRSAQIATPKKT------PVST--RA 480
            ||| |....|:...||..:....||.....   ..|:.:.:...:|..:::      .:||  |.
Human    64 GYP-ECWNPSERKMESGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRL 127

  Fly   481 SRQ--EKVKKEPNGDQKLRSRGSKHLDNNPTEYKF--LPTEEEHVFLIDFGLASKFQDR-GVHRP 540
            .||  |.:       :.:.|.|..|.|..|:.:..  .|:.....:::|||||.:|.:. |..||
Human   128 GRQILESI-------ESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRP 185

  Fly   541 FIMDQRRA---HDGTLEFTSRDAH----LGAHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQE 598
                 .||   ..||:.:.|.:||    :|.|   .||..|.|.|:.:..|.|||:.:   :.:|
Human   186 -----PRAVAGFRGTVRYASINAHRNREMGRH---DDLWSLFYMLVEFVVGQLPWRKI---KDKE 239

  Fly   599 KVHRAKELFMTDVPEMLRQFYGKQVPKYLGEFLLQIGQLAYQERPNYERYRKIFKREYQRLGY-- 661
            :|...||.:  |...||     |.:|.....||..|..|.|..:|:|:....:|....:..|.
Human   240 QVGSIKERY--DHRLML-----KHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIE 297

  Fly   662 -DPCQMRLSSEE--ILRTCVSTKDVVDGSKCDIFELNNK---AAVNV----------MRNSTLST 710
             ||.....:..:  :..|..||..          :|:.:   ||:.:          :|.:| ..
Human   298 SDPFDWEKTGNDGSLTTTTTSTTP----------QLHTRLTPAAIGIANATPIPGDLLRENT-DE 351

  Fly   711 PFQEHSLTN-------RVSPKNLRSKSNKKTTKKKFSWAE------------------------- 743
            .|.:..|::       .|||..|.........::|..|.|
Human   352 VFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQ 416

  Fly   744 ---------------VLSQ--DPDQ----IARERAVKEFEREETICPLESRLPRRYEGKP-TYAI 786
                           |.|:  .||:    :.:.|::..||       ||.||  ..|.|| |...
Human   417 ANGLLNAPSLGSPIRVRSEITQPDRDIPLVRKLRSIHSFE-------LEKRL--TLEPKPDTDKF 472

  Fly   787 LD--MEQRRREKGLVVQE---------------------HIEEE-------------EEDADE-- 813
            |:  :|:.:::.....:.                     |.:||             .|.||.
Human   473 LETCLEKMQKDTSAGKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGG 537

  Fly   814 ------------DDEEENQEAMDIDQEED----------GEAADSAEGEDESD--RSMEGSDC-- 852
                        ..|.:::|.:.:|:|:|          |.....:..::|.:  :.:|.|..
Human   538 SNGFIAVNLSSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDE 602

  Fly   853 ---------SDHSQKR---------ARGRPKGTSRKQTTSRQAQPHQNQPPVKVHRGVGRPGKNS 899
                     :||.:|.         |.|.|...|.:.|...:.|                ||..|
Human   603 KLQLGPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQ----------------PGAAS 651

  Fly   900 GVVKLAAGAVSKNR--------TTPLSAVASNKR-----GCATRKENSTL--------------- 936
            ..:.....::.:.:        |.|..:|||.:.     .|..:.|...|
Human   652 QFIAATPTSLMEAQAEGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPREN 716

  Fly   937 --ASATGEGERKLKSGRTRRALYKTEPKHGEHD-----AENNSS------------LLVV---QN 979
              .....|||......||...|   :..|..||     .|:|.|            .|||   :|
Human   717 FSGLVVTEGEPPSGGSRTDLGL---QIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFEN 778

  Fly   980 LYGEYDDEN----NYGKGRSVHSSRHC 1002
            |.||.::::    :..:...:...:||
Human   779 LPGETEEKSILLESDNEDEKLSRGQHC 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8878	NP_001260913.1	PKc_like	112..>286	CDD:304357
		SPS1	123..>284	CDD:223589
		SPS1	<491..756	CDD:223589	74/345 (21%)
		PKc_like	<517..652	CDD:304357	43/142 (30%)
TTBK2	XP_005254228.1	PKc_like	75..287	CDD:304357	61/236 (26%)
TTBK2	XP_005254228.1	SPS1	78..>267	CDD:223589	55/213 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900