DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8878 and Ttbk2

DIOPT Version :9

Sequence 1:	NP_001260913.1	Gene:	CG8878 / 36302	FlyBaseID:	FBgn0027504	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_542966.2	Gene:	Ttbk2 / 140810	MGIID:	2155779	Length:	1312	Species:	Mus musculus

Alignment Length:	547	Identity:	115/547 - (21%)
Similarity:	197/547 - (36%)	Gaps:	133/547 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 QKLRSRGSKHLDNNPTEYKF--LPTEEEHVFLIDFGLASKFQDR-GVHRPFIMDQRRA---HDGT 552
            :.:.|.|..|.|..|:.:..  .|:.....|::|||||.:|.:. |..||     .||   ..||
Mouse   199 ESIHSVGFLHRDIKPSNFAMGRFPSTCRKCFMLDFGLARQFTNSCGDVRP-----PRAVAGFRGT 258

  Fly   553 LEFTSRDAH----LGAHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPE 613
            :.:.|.:||    :|.|   .||..|.|.|:.:..|.|||:.:   :.:|:|...||.:  |...
Mouse   259 VRYASINAHRNREMGRH---DDLWSLFYMLVEFVVGQLPWRKI---KDKEQVGSIKERY--DHRL 315

  Fly   614 MLRQFYGKQVPKYLGEFLLQIGQLAYQERPNYERYRKIFKREYQRLGY---DPCQMRLSSEEILR 675
            ||     |.:|.....||..|..|.|..:|:|:....:|....:..|.   ||....
Mouse   316 ML-----KHLPPEFSTFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWE-------- 367

  Fly   676 TCVSTKDVVDGSKCDIFELNNKAAVNVMRNSTLSTPFQEHSLTNRVSPKNLRSKSNKKTTKKKFS 740
                 |...|||              :...:|.:||    .|..|::|..:...:.....
Mouse   368 -----KSGTDGS--------------LTTTTTSATP----QLHTRLTPAAIGIANATPIP----- 404

  Fly   741 WAEVLSQDPDQIARERAVKEFEREETICPLESRLP-----RRYEGKPTYAILDMEQRRREKGLVV 800
             .::|.::.|::..:..:.:.|....:.....:||     .|.:.|..:..:|:.:.:.:.| :.
Mouse   405 -GDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDINKNKIKLG-IC 467

  Fly   801 QEHIEEEEEDADEDD--------------EEENQEAMDID--------QEEDGEAADSAEGEDES 843
            :...|||......:.              .|..|...|:.        ...:.|...:.|.:.::
Mouse   468 KAATEEENSHGQVNGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLTLEPKPDT 532

  Fly   844 DRSMEGSDCSDHSQKRARGRPKGTSRKQTTSRQAQPHQNQPPVKVHR------------GVGRPG 896
            |:.:|  .|.:..|       |.:|..:.....|.||:...||..|.            ...:|.
Mouse   533 DKFLE--TCMEKMQ-------KDSSAGKEPVPPALPHKPCVPVVTHTDHIWHYDDEYLPDASKPA 588

  Fly   897 KNSGVVKLAAGAVSKNRTTPLSAVASNKRGCATRKENSTLASATGEGERKLKSGRTRRAL-YKTE 960
             ::...:.|.|..|.      ..:|.|...|  ::|..:......:.|:.|:..||...| :||.
Mouse   589 -SANTPEQADGGGSN------GFIAVNLSSC--KQEVDSKEWVIVDKEQDLQDFRTNEVLGHKTT 644

  Fly   961 PKHGEHDAENNSSLLVVQNLYGEYDDE 987
            ....:.:.|      |:|.|.|...||
Mouse   645 GSPSDEEPE------VLQVLEGSPQDE 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8878	NP_001260913.1	PKc_like	112..>286	CDD:304357
		SPS1	123..>284	CDD:223589
		SPS1	<491..756	CDD:223589	66/274 (24%)
		PKc_like	<517..652	CDD:304357	44/142 (31%)
Ttbk2	NP_542966.2	STKc_TTBK2	89..350	CDD:271031	50/168 (30%)
Ttbk2	NP_542966.2	Pkinase	90..329	CDD:278497	44/147 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900