Protein Alignment CG8878 and Vrk3

DIOPT Version :9

• Sequence 1: NP_001260913.1
• Gene: CG8878 / 36302
• FlyBaseID: FBgn0027504
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: NP_598706.1
• Gene: Vrk3 / 101568
• MGIID: 2182465
• Length: 453
• Species: Mus musculus
• Alignment Length: 697
• Identity: 129/697 - (18%)
• Similarity: 204/697 - (29%)
• Gaps: 298/697 - (42%)

  Fly     2 GKRLQLERPTTDRSA-----------RKRKRSAVKAAEKRQRLSGGSSSANGFEFHENDDEESCS 55
            ||.|.:|.....:||           |:...|:.:.:.|:.:.   |.:........:.|   |.
Mouse    23 GKALPVEEDGGTQSAVTPHVSSVPGSRRDLNSSFETSPKKVKC---SHTVTSLPLSRHSD---CD 81

  Fly    56 SAGS---------AAGTEADPPTLLHTPQARSLLLTGASIASDHNNSSVMESPRPVYTLRPSVVN 111
            |:||         |.||.:.|    .||:...|        |:..:...::..| |.|...::..
Mouse    82 SSGSDNTLTSPDRATGTRSRP----LTPKGSPL--------SNRQSPQTLKRTR-VTTSLQALAT 133

  Fly   112 GTILRDVLSKAWRLGRPIGKGNFGEIFLASDDTVCPASSETAKYVVKIEPHS-NGPLFVEIHCLI 175
            ||.|.|...|.|.||....:.:.|.::.|...:..|:.|.|.|:...::..| :|.||.|
Mouse   134 GTELTDQNGKHWTLGALQIRDDQGILYEAEPTSAVPSESRTQKWRFSLKLDSKDGRLFNE----- 193

  Fly   176 NTSRNNDLSDAAEDAASLPAPQTHVLSRGPPSGIPSFIASGTHYFGDVRYRFLVLPRFDRDLHSL 240
                .|.....|:........:..:|   |...||:.|..|.|   ..:|||||.|...|.|.|.
Mouse   194 ----QNFFQRVAKPLQVNKWKKQFLL---PLLAIPTCIGFGIH---QDKYRFLVFPSLGRSLQSA 248

  Fly   241 IKNSR---VQQKSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSKCKYLRRQVVPKGNGYEDH 302
            :.::.   |.::.:|.:|..:::.||.||:..|.|.::.|:|:.|:
Mouse   249 LDDNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVN------------------- 294

  Fly   303 YEEKQQTTDSGNSSEQETNDDDYFLKSEKFALKKIVDIKQDEDEDDEDFDDGATSNSNNSNSLDV 367
                                                                             
Mouse   295 ----------------------------------------------------------------- 294

  Fly   368 FHTPVNKKRSARNAIQFSGSNPVRACRREKRNSMYEEMVKSHYLRPTKRISYREEFNEDGYPKET 432
                                                                             
Mouse   295 ----------------------------------------------------------------- 294

  Fly   433 AENSDESPESSDNESDEFIPPSSRRSVIKRGRSAQIATPKKTPVSTRASRQEKVKKEPNGDQKLR 497
                                                                             
Mouse   295 ----------------------------------------------------------------- 294

  Fly   498 SRGSKHLDNNPTEYKFLPTEEEHVFLIDFGLASKFQDRGVHRPFIMDQRRAHDGTLEFTSRDAHL 562
                             |.:...|.|:.:|...::...|.|..:....|..|||.|||.|.|.|.
Mouse   295 -----------------PEDLSQVTLVGYGFTYRYCPGGKHVAYKEGSRSPHDGDLEFISMDLHK 342

  Fly   563 G-AHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLRQFYGK--QVP 624
            | ..||||||:.|||.:|.|..|.|||.:..  ...||:.|.|:.:: |.||.|....|:  :..
Mouse   343 GCGPSRRSDLQTLGYCMLKWLYGSLPWTNCL--PNTEKITRQKQKYL-DSPERLVGLCGRWNKAS 404

  Fly   625 KYLGEFLLQIGQLAYQERPNYERYRKIFKREYQRL---GYDPCQMRL 668
            :.|.|:|..:..|.|:|:|.|...|...:...|.:   .|||..:::
Mouse   405 ETLREYLKVVMALNYEEKPPYATLRNSLEALLQDMRVSPYDPLDLQM 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8878	NP_001260913.1	PKc_like	112..>286	CDD:304357	49/177 (28%)
		SPS1	123..>284	CDD:223589	44/164 (27%)
		SPS1	<491..756	CDD:223589	54/184 (29%)
		PKc_like	<517..652	CDD:304357	49/137 (36%)
Vrk3	NP_598706.1	zinc_ribbon_2	4..26	CDD:379084	2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..123		19/110 (17%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:14645249	49..64		3/14 (21%)
		PKc_like	134..436	CDD:389743	99/550 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4829
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.820