DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-4 and smyd1b

DIOPT Version :9

Sequence 1:	NP_610730.1	Gene:	Smyd4-4 / 36299	FlyBaseID:	FBgn0027495	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001034725.1	Gene:	smyd1b / 569027	ZFINID:	ZDB-GENE-060522-1	Length:	486	Species:	Danio rerio

Alignment Length:	430	Identity:	82/430 - (19%)
Similarity:	144/430 - (33%)	Gaps:	142/430 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 LELRETAAEGRFVVTNRDLAVGDLVSVEEPFCSTLLTPMRYIRCATCKRENYLTLIPCDSCCSTM 251
            :|:.::..:||.:...::...||::..|.||.|.:........|.:|.|... .|..|..|....
Zfish     4 VEVFDSPGKGRGLRATKEAWAGDVLFAEPPFASVVFDSQASSICHSCFRRQE-KLQRCGQCRFAQ 67

  Fly   252 FCSEECKSIAMQTYHRYECPIIDFLNRMFNKIHCIALRTTLVALNIFPSIEELIDFCEQEQNQDK 316
            :|.:.|:....:.:                |:.|.|::|
Zfish    68 YCDKTCQRAGWEEH----------------KLECAAIKT-------------------------- 90

  Fly   317 CAFDLNYNELTPEEHYRAI----------HGLVTNQHLRSVSDLFQRSVVCAV----LKHFIIEY 367
                  |.: .|.|:.|..          ..:|::..|.::.||  ...:|.:    ||.|.::
Zfish    91 ------YGK-PPSENVRLAARILWRMDKQGSVVSDNQLTTLEDL--EDHICDISEDDLKDFKVD- 145

  Fly   368 TPVKEYLGGEEGVNFFTDLLFRHLQTSPSNMHGIDLVE-----------QVNETKDDQTHSSGAY 421
                        ::.|.|...|:     |..|.:|.|.           .|::.:..|....|.:
Zfish   146 ------------IHNFLDYWPRN-----SKPHTVDSVSHILGVINCNGFMVSDQRGLQAVGVGLF 193

  Fly   422 AFLSLINHSCAPN-TVRIYEGTKA------------YMFVLRPIKAGNVLYDNYGAHFAICSKEQ 473
            ..|.|:||.|.|| ||.:..|.::            .:..|..|.||..:...|..:..:.:..|
Zfish   194 PNLCLVNHDCWPNCTVILNNGNQSAIDTVFHSQKRIELRALGKISAGEEVTVAYVDYLNVSADRQ 258

  Fly   474 RLKRLSLQYRFDCKCEGC-------------ELNYPMFGMMPHKATVPSVTDDTELALSSYNYDF 525
            ||  |..||.|||.|:.|             |::    |:...:..|..||:.:...|.......
Zfish   259 RL--LKQQYFFDCTCKHCTEKIKDDLKMAGAEVD----GVKVPEEQVKEVTEFSRQKLEKMEKAR 317

  Fly   526 AVSNYRKYCDFLTQYGDDYPCEQISSAEECLKMALHIMAD 565
            ..:||.               |.:....||::...:::||
Zfish   318 IEANYN---------------EVVKICRECVEKQENVLAD 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-4	NP_610730.1	TPR_11	67..138	CDD:290150
		zf-MYND	230..270	CDD:280009	8/39 (21%)
		SET	363..463	CDD:279228	25/123 (20%)
smyd1b	NP_001034725.1	zf-MYND	47..85	CDD:280009	9/54 (17%)
smyd1b	NP_001034725.1	SET	<173..247	CDD:214614	17/73 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810