DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-4 and smyd5

DIOPT Version :9

Sequence 1:	NP_610730.1	Gene:	Smyd4-4 / 36299	FlyBaseID:	FBgn0027495	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001004614.2	Gene:	smyd5 / 447875	ZFINID:	ZDB-GENE-040912-39	Length:	415	Species:	Danio rerio

Alignment Length:	396	Identity:	82/396 - (20%)
Similarity:	136/396 - (34%)	Gaps:	122/396 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 ADCLELR-ETAAEGRFVVTNRDLAVGDLVSVEEPFCSTLL---TPMRYIRCATCKR------EN- 237
            ::|:::| ....:|:.:...:....||.:.:|.|..|:..   ...:|..|..|.|      ||
Zfish    19 SNCVDVRFINNVKGKGLFAKKPFKKGDTIFIERPLVSSQFLWNALYKYRACEYCLRALETAEENA 83

  Fly   238 -YLTLIPC----------------DSC--CSTMFCSEECKSIAMQTYHRYEC--PIIDFLNRMFN 281
             .|:.:|.                .:|  |..|:||.||:..||..||:..|  |..|..:...|
Zfish    84 RRLSGLPALILPHPELCKVRPDRHQACPQCQVMYCSSECRQAAMDQYHKILCLGPSNDDPDHPVN 148

  Fly   282 KIHCIALR---------TTLVALNIFPSIEELID----------FCEQEQNQDK----------- 316
            |:. .|.|         :.::...:..:|::..|          ||.:..|:::
Zfish   149 KLQ-DAWRSVHFPPETSSVMILAKMVATIKQTQDKERWQRLFTNFCSRTANEEEEIVHKLLGEKF 212

  Fly   317 -------------CAFDLNYNELTPEEHYRAIHGLV-TNQHLRSVSDLFQRSVVCAVLKHFIIEY 367
                         ..::...::....|.:|::..|| ||......|.|.|....|..|:
Zfish   213 QGQLGLLRNLFTTALYEDRLSQWFTPEGFRSLFSLVGTNGQGIGTSSLSQWVHACDALE------ 271

  Fly   368 TPVKEYLGGEEGVNFFTDLLFRHLQTSPSNMHGIDLVEQVNETKDD-QTHSSGAYAFLSLINHSC 431
            .|.::    .|.::.|.|.|::.:.               .||.|. ....||.:...|..||||
Zfish   272 LPRQQ----REQLDAFIDQLYKDID---------------KETGDFLNCEGSGLFLLQSSCNHSC 317

  Fly   432 APNTVRIYEGTKAYMFVLRPIKAGNVLYDNYGAHFAIC-----------SKEQRLKRLSLQYRFD 485
            .||....:....   |:|.....|::     |....||           |:..|.|.|...|.|.
Zfish   318 VPNAEASFPENN---FLLHLTALGDI-----GPGEEICISYLDCCQRDRSRHSRHKILRENYLFI 374

  Fly   486 CKCEGC 491
            |.|:.|
Zfish   375 CSCQKC 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-4	NP_610730.1	TPR_11	67..138	CDD:290150
		zf-MYND	230..270	CDD:280009	18/65 (28%)
		SET	363..463	CDD:279228	20/100 (20%)
smyd5	NP_001004614.2	zf-MYND	100..135	CDD:280009	11/34 (32%)
smyd5	NP_001004614.2	SET	<293..350	CDD:214614	18/64 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810