DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-4 and SmydA-3

DIOPT Version :9

Sequence 1:	NP_610730.1	Gene:	Smyd4-4 / 36299	FlyBaseID:	FBgn0027495	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001260366.1	Gene:	SmydA-3 / 34502	FlyBaseID:	FBgn0262599	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	93/435 - (21%)
Similarity:	156/435 - (35%)	Gaps:	140/435 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 LELRETAAE-----GRFVVTNRDLAVGDLVSVEEPF-----CSTLLTPMRYIRCATCKRENYLTL 241
            |.:..||.:     ||::|....:....|:..|.||     |:..:.      |..|...|   .
  Fly     7 LSVNRTAVQWSPVCGRYLVAKGAIRGHGLLIEELPFAVGPKCNGPVV------CLGCYEPN---P 62

  Fly   242 IPCDSCCSTM---FCSEECKSIAMQTYHRYEC-PIIDFLNRMFN---------KIHCIALRTTLV 293
            .|.:..||..   .| .||...|...:.|.|| .:.|...|.|.         ::.||.....|:
  Fly    63 DPEEELCSECGWPLC-VECAQQADNAHFRLECSQLKDARARFFRLPSGSRHCPQLDCIMPLRVLL 126

  Fly   294 ALNIFPSIEELIDFCEQEQNQDKCAFDLNYNELTPEEHYRAIHGLVTNQHLRSVSDLFQRSVVCA 358
            |               :|.|.::  :|   ||:.|.||::        :..:..:|::....|
  Fly   127 A---------------KEANPER--WD---NEVAPMEHHK--------EERQRDADVWHADRV-- 161

  Fly   359 VLKHFIIEYTPVKEYLGGE-EGVNFFTDLLFRHLQTSPSNMHGIDLVEQVN--ETKDDQTHSSGA 420
                      .:.:||.|. :..|.|::.|.         |..:.::| ||  |.:..:.:....
  Fly   162 ----------NIAQYLRGPCQLANRFSEELI---------MQVVGVLE-VNAFEARSPKGYPLRC 206

  Fly   421 -YAFLSLINHSCAPNTVR-IY--EGTKAYMFVLRPIKAGNVLYDNYGAHFAICSKEQRLKRLSLQ 481
             :.:..::.|:|.|||.| ||  ||.|..:..:..::.|..|:.:|  .:.:....||.|.|...
  Fly   207 LFPYTGILAHNCVPNTSRSIYPSEGYKIRLRAMVDLEEGQPLHHSY--TYTLDGTAQRQKHLKQG 269

  Fly   482 YRFDCKCEGC----ELNYPMFGM----------MPHKATVPSVTDDTELALSSYNYDFAVSNYRK 532
            ..|.|:||.|    ||......:          :|.:.|.|    ||     |:|    .:|
  Fly   270 KFFTCQCERCLDPTELGTHFSSLKCGQCAEGFQVPRQPTEP----DT-----SWN----CAN--- 318

  Fly   533 YCDFLTQYGDDYPCEQISSAEECLKMALHIMAD-----AVPLKAK 572
                         |...:|..:.|.|...:.::     |:|:.||
  Fly   319 -------------CGSDTSNADALAMLQSLQSEVNAVQALPMAAK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-4	NP_610730.1	TPR_11	67..138	CDD:290150
		zf-MYND	230..270	CDD:280009	11/42 (26%)
		SET	363..463	CDD:279228	24/106 (23%)
SmydA-3	NP_001260366.1	SET	<207..252	CDD:250181	13/44 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810