DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-4 and Smyd5

DIOPT Version :9

Sequence 1:	NP_610730.1	Gene:	Smyd4-4 / 36299	FlyBaseID:	FBgn0027495	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001101340.1	Gene:	Smyd5 / 312503	RGDID:	1309153	Length:	417	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	90/410 - (21%)
Similarity:	143/410 - (34%)	Gaps:	129/410 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 TAAEGRFVVTNRDLAVGDLVSVEEPFCSTLL---TPMRYIRCATCKR------ENYLTL------ 241
            ::|:|:.:...:.:..|:.:.:|.|..::..   ...||..|..|.|      ||...|
  Rat    29 SSAKGKGLFATQLIRKGETIFIERPLVASQFLWNALYRYRACDHCLRALEKAEENAQRLTGKPGQ 93

  Fly   242 -IP----C-------DSC--CSTMFCSEECKSIAMQTYHRYECP---------IIDFLNRMFNKI 283
             :|    |       .:|  |...:||.||:..|.:.||:..||         .::.|...:..:
  Rat    94 VLPHPELCSVRKDLHQNCPRCQVTYCSAECRLAAAEQYHQILCPGPSQDDPRHPLNKLQEAWRSV 158

  Fly   284 H------CIALRTTLVALNIFPSIEELID----------FCEQEQNQ----------DKCAFDLN 322
            |      .|.|...:||     ::::..|          ||.:..|:          ||....|.
  Rat   159 HYPPETASIMLMARMVA-----TVKQAKDKDHWVRLFSHFCSKTANEEEEIVHKLLGDKFKGQLE 218

  Fly   323 ----------YNE-----LTPEEHYRAIHGLV-TNQHLRSVSDLFQRSVVCAVLKHFIIEYTPVK 371
                      |.|     .|| :.:|::..|| ||......|.|.|....|..|     |..|.:
  Rat   219 LLRRLFTEALYEETLSQWFTP-DGFRSLFALVGTNGQGIGTSSLSQWVHACDAL-----ELKPQE 277

  Fly   372 EYLGGEEGVNFFTDLLFRHLQTSPSNMHGIDLVEQVNETKDDQTHSSGAYAFLSLINHSCAPNTV 436
                 .|.::.|.|.|::.::.:..        |.:|      ...||.:...|..||||.||..
  Rat   278 -----REQLDTFIDQLYKDIEAATG--------EFLN------CEGSGLFVLQSCCNHSCVPNAE 323

  Fly   437 RIYEGTKAYMFV--LRPIKAGNVLYDNYGAHFAICSKEQ----RLKRLSLQYRFDCKCEGCELNY 495
            ..:......:.|  |..|:.|..:..:|   ...|.:|:    |.|.|...|.|.|.|..|..
  Rat   324 TSFPENNFLLHVTALEDIEPGEEICISY---LDCCQRERSRHSRHKILRENYLFVCSCPKCLA-- 383

  Fly   496 PMFGMMPHKATVPSVTDDTE 515
                    :|..|:||.:.|
  Rat   384 --------EADDPNVTSEEE 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-4	NP_610730.1	TPR_11	67..138	CDD:290150
		zf-MYND	230..270	CDD:280009	17/65 (26%)
		SET	363..463	CDD:279228	21/101 (21%)
Smyd5	NP_001101340.1	DUF4599	68..144	CDD:292015	19/75 (25%)
Smyd5	NP_001101340.1	SET	<298..351	CDD:214614	15/58 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810