Protein Alignment Smyd4-4 and Smyd4

DIOPT Version :10

• Sequence 1: NP_610730.1
• Gene: Smyd4-4 / 36299
• FlyBaseID: FBgn0027495
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_001099280.1
• Gene: Smyd4 / 287525
• RGDID: 1307369
• Length: 801
• Species: Rattus norvegicus
• Alignment Length: 659
• Identity: 153/659 - (23%)
• Similarity: 250/659 - (37%)
• Gaps: 157/659 - (23%)

  Fly    46 DFKYIEKIFLNVTLREDKCNKRSVEFRMLGNEQFSLKNRNYFQALELYNKSICYAEPNSEHLSIG 110
            |..:::::..:.::.:|  :...:.:|..||::|  :.:.|..|..||:|.:.::.||:|.:|:.
  Rat    48 DEMFLKQLSSSCSVEKD--SGAPLFYREEGNKRF--QEKEYMGAAVLYSKGVSHSRPNTEDISLC 108

  Fly   111 YANRSAVLFEWKRYRQCLDNIKLARQANYPARLSHKLDKRERDC--------------------- 154
            ||||||.||...::..||.:|..|....||.||..||..|:.:|
  Rat   109 YANRSAALFHLGQHEACLKDIVRAGMHGYPERLQPKLMIRKTECLVNLGRLQEARQTISDLENSL 173

  Fly   155 ------------------QQL-LDQQPPDVVPYEFKLSF----------EPHAQVPFIADCLELR 190
                              ||| :..|..:.:|..|..:.          |.:.|:...:..:.|.
  Rat   174 TTKPTLMPSSHQILQRNVQQLKMKIQEKETLPESFPAALTKALEDMALGEENKQISGASLSVSLC 238

  Fly   191 ETAAEGRFVVTNRDLAVGDLVSVEEPFCSTL----LTPMRY--------------IRCATCKREN 237
            ....:||.:|..:|:..|:|:..|:.|.|.|    :.|:|:              :.|..|.|..
  Rat   239 TDPLKGRHLVATKDILPGELLVKEDAFVSVLNPGEMPPLRHCLENKWDTRVTSADLYCHRCLRHT 303

  Fly   238 YLTLIPCDSCCSTMFCSEECKSIAMQTYHRYECPIIDFLNRMFNKIHC-IALRTTLVALNIFPSI 301
             |..:||..|....:||:||...|...||..||.:...|..:  .:.| :|||.||:|.  |..:
  Rat   304 -LATVPCGGCSYAKYCSQECVQQAWDHYHSTECSLGGLLLTL--GVFCHVALRMTLLAR--FEDV 363

  Fly   302 EELI----------DFC-----------------EQEQNQDKCAFDL---NYNELTPEEHYRAIH 336
            :.:|          |.|                 |.|:|.:.|...:   |.|. ..|.:|.|:.
  Rat   364 DRVIRMICDKTGRKDTCLPESKDLVKTFGYTNQGESEENSETCEPSIPGCNVNG-KYENNYDAVL 427

  Fly   337 GLVTNQHLRSVSDLFQRSVVCAVLKHFIIEYTPVKEYLGGEEGV----------NFFTDL----- 386
            .|:.:....|....|    :|||....:..............|:          ...|||
  Rat   428 SLLPHTEKHSPEHKF----ICAVSVSALCRQLKATSLQAQTTGLKSPRLKAVTPGLCTDLTVWGV 488

  Fly   387 -LFRHLQTSPSNMHGIDLVEQVNETKDDQTHS------SGAYAFLSLINHSCAPNTVRIYEGTKA 444
             :.:|:.....|...|..:......:...|:|      :|.:..:||:||||:|||...:..|.|
  Rat   489 AMLQHMLQLQCNAQAITSICYAGSKESIITNSRQVRLATGVFPVVSLLNHSCSPNTSVSFTSTVA 553

  Fly   445 YMFVLRPIKAGNVLYDNYGAHFAICSKEQRLKRLSLQYRFDCKCEGCELNYPMFGMMP------- 502
            .:...:.|..|..:...||.|.:.....:|.:|||.||.|||.|..|........:.|
  Rat   554 TIRAAQQIAKGQEILHCYGPHESRMGVAERQQRLSSQYFFDCSCPACHAETLRAAVAPRWEAFCC 618

  Fly   503 HKATVPSVTDD-----TELALSSYNYDFAVSNYRKYCDFLTQ-------YGDDYPCEQISSAEEC 555
            :...||...:|     .|...:|.:.|..||..:   |...|       ...|.|.:.|....||
  Rat   619 NTCRVPMQGNDVLSCSNESCTNSVSRDRLVSRLQ---DLQQQVHTAQKLLRSDRPEQAIQQLLEC 680

  Fly   556 LKMALHIMA 564
            .:.|.:.::
  Rat   681 QRAAENFLS 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-4	NP_610730.1	SET_SMYD4	180..491	CDD:380934	92/381 (24%)
		zf-MYND	230..270	CDD:460312	14/39 (36%)
Smyd4	NP_001099280.1	3a0801s09	7..>211	CDD:273380	41/166 (25%)
		TPR repeat	68..96	CDD:276809	9/29 (31%)
		TPR repeat	101..136	CDD:276809	15/34 (44%)
		SET	239..>269	CDD:394802	9/29 (31%)
		zf-MYND	296..335	CDD:460312	14/39 (36%)
		SET_SMYD4	418..600	CDD:380934	45/185 (24%)
		TPR_12	661..728	CDD:315987	6/29 (21%)