DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-4 and Smyd5

DIOPT Version :9

Sequence 1:	NP_610730.1	Gene:	Smyd4-4 / 36299	FlyBaseID:	FBgn0027495	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_659167.2	Gene:	Smyd5 / 232187	MGIID:	108048	Length:	416	Species:	Mus musculus

Alignment Length:	423	Identity:	95/423 - (22%)
Similarity:	151/423 - (35%)	Gaps:	133/423 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 IAD----CLELRET-AAEGRFVVTNRDLAVGDLVSVEEPFCSTLL---TPMRYIRCATCKR---- 235
            :||    .:|:|.. :.:|:.:...:.:..|:.:.:|.|..:...   ...:|..|..|.|
Mouse    15 VADRARGSVEVRYVDSIKGKGLFATQLIRKGETIFIERPLVAAQFLWNALYQYRACDHCLRALEK 79

  Fly   236 --EN--YLT-----LIP----C-------DSC--CSTMFCSEECKSIAMQTYHRYECP------- 271
              ||  .||     ::|    |       .:|  |..|:||.||:..|.:.||:..||
Mouse    80 AEENAQRLTGKPSQILPHPELCSVRKDLHQNCPHCQVMYCSAECRLAAAEQYHQILCPGPSHDPR 144

  Fly   272 -IIDFLNRMFNKIH------CIALRTTLVALNIFPSIEELID----------FCEQEQNQDKCAF 319
             .::.|...:..:|      .|.|...:||     ::::..|          ||.:..||::...
Mouse   145 HPLNKLQEAWRSVHYPPETASIMLMARMVA-----TVKQAKDKDHWVRLFNHFCSRTANQEQAIV 204

  Fly   320 --------------------DLNYNE-----LTPEEHYRAIHGLV-TNQHLRSVSDLFQRSVVCA 358
                                :..|.|     .|| |.:|::..|| ||......|.|.|....|.
Mouse   205 HKLLKGKFKDQLELLLGLFKEALYEEALSLWFTP-EGFRSLFALVGTNGQGIGTSSLSQWVHACD 268

  Fly   359 VLKHFIIEYTPVKEYLGGEEGVNFFTDLLFRHLQTSPSNMHGIDLVEQVNETKDDQTHSSGAYAF 423
            .|     |.||     ...|.::.|.|.|::.::.:..        |.:|      ...||.:..
Mouse   269 AL-----ELTP-----QDREQLDTFIDQLYKDIEAATG--------EFLN------CEGSGLFVL 309

  Fly   424 LSLINHSCAPNTVRIYEGTKAYMFV--LRPIKAGNVLYDNYGAHFAICSKEQ----RLKRLSLQY 482
            .|..||||.||....:......:.|  |..||.|..:..:|   ...|.:|:    |.|.|...|
Mouse   310 QSCCNHSCVPNAETSFPENNFVLHVTALEDIKPGEEICISY---LDCCQRERSRHSRHKILRENY 371

  Fly   483 RFDCKCEGCELNYPMFGMMPHKATVPSVTDDTE 515
            .|:|.|..|..          :|..|:||.:.|
Mouse   372 LFNCSCPKCLA----------EADDPNVTSEEE 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-4	NP_610730.1	TPR_11	67..138	CDD:290150
		zf-MYND	230..270	CDD:280009	19/65 (29%)
		SET	363..463	CDD:279228	23/101 (23%)
Smyd5	NP_659167.2	SET	<297..350	CDD:214614	16/58 (28%)
Smyd5	NP_659167.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..416		5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810