DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-4 and set-30

DIOPT Version :9

Sequence 1:	NP_610730.1	Gene:	Smyd4-4 / 36299	FlyBaseID:	FBgn0027495	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_508850.2	Gene:	set-30 / 180772	WormBaseID:	WBGene00022499	Length:	560	Species:	Caenorhabditis elegans

Alignment Length:	326	Identity:	76/326 - (23%)
Similarity:	115/326 - (35%)	Gaps:	109/326 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 DLVSVEE-----------PFCSTLLTPMRYIRCATCKRENYLTLIPCDSCCSTMFCSEECK-SIA 261
            ::|.||:           ||..:||...:...|.||..||  ..:.|:.|....|||::|: |.|
Worm     9 EVVGVEKIGSKPRSKEFYPFAYSLLDCTKDDYCWTCLGEN--VELTCEQCKVAKFCSKQCETSGA 71

  Fly   262 MQTYHRYEC-PIIDFLNRMFNKIHCIALRTTLVALNIFPSIEELIDFCEQEQNQDKCAFDLNYNE 325
            :.  |:||| |:                                          .||. |||.:|
Worm    72 ID--HKYECGPL------------------------------------------KKCP-DLNTDE 91

  Fly   326 ---LTPEEHYRAIH--------GLVTN-QHLRSVSDLFQRSVVCA-------VLKHFIIEYTPVK 371
               :.....|:.||        |...| :..|||.::::.   ||       .:|.|...|..||
Worm    92 RMLIRIVGRYKDIHSGKDKSIDGFYNNRESKRSVMEIWEH---CADMKKDENAMKSFKKTYDRVK 153

  Fly   372 EYLGGEEGVNFFTDLLFRHLQTSPSNMHGIDLVEQVNETKDDQTHSSGAYAFLSLINHSCAPNTV 436
            ::  |:.......::.|:....:..|.|.|..|:.:.|.      ..|.|..|...:|||.||.:
Worm   154 QF--GDTNHLMDEEVTFQLHSRNFINRHSISNVDYLREI------GKGLYLDLCKYDHSCRPNAI 210

  Fly   437 RIYEGTKAYMFVLRPIKAGNVLYDNYG------AHFAICS----KEQRLKRLSLQYRFDCKCEGC 491
            ....|..|.:         ..|:||..      .|:....    |.||...|...:.|:|.||.|
Worm   211 YSCNGIVAKL---------RALHDNVDLENVETTHYTYIELPPCKIQRRHMLKETWYFECHCERC 266

  Fly   492 E 492
            :
Worm   267 D 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-4	NP_610730.1	TPR_11	67..138	CDD:290150
		zf-MYND	230..270	CDD:280009	15/40 (38%)
		SET	363..463	CDD:279228	24/99 (24%)
set-30	NP_508850.2	zf-MYND	41..78	CDD:366792	15/40 (38%)
set-30	NP_508850.2	SET_SMYD	<179..266	CDD:380997	26/101 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810