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Protein Alignment Smyd4-4 and SMYD4

DIOPT Version :9

Sequence 1:	NP_610730.1	Gene:	Smyd4-4 / 36299	FlyBaseID:	FBgn0027495	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_443160.2	Gene:	SMYD4 / 114826	HGNCID:	21067	Length:	804	Species:	Homo sapiens

Alignment Length:	621	Identity:	147/621 - (23%)
Similarity:	242/621 - (38%)	Gaps:	147/621 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 FRMLGNEQFSLKNRNYFQALELYNKSICYAEPNSEHLSIGYANRSAVLFEWKRYRQCLDNIKLAR 135
            :|..||::|  :.::|..|..||:|.:.::.||:|.:|:.:|||||.||...:|..||.:|..|:
Human    71 YREEGNKKF--QEKDYTGAAVLYSKGVSHSRPNTEDMSLCHANRSAALFHLGQYETCLKDINRAQ 133

  Fly   136 QANYPARLSHKLDKRERDC-----------QQLLDQQP--------PDVVP-------YEFKLSF 174
            ...||.||..|:..|:.:|           |.:.|.:.        .||:|       :..|:..
Human   134 THGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALADVLPQTLQRNLHRLKMKM 198

  Fly   175 E---------PHAQVPFIADCLELRE----------------TAAEGRFVVTNRDLAVGDLVSVE 214
            :         |.|....:.|. .|||                ...:||.:|..:|:..|:|:..|
Human   199 QEKDSLTESFPAALAKTLEDA-ALREENEQLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQE 262

  Fly   215 EPFCSTL----LTPMRY--------------IRCATCKRENYLTLIPCDSCCSTMFCSEECKSIA 261
            :.|.|.|    |.|..:              :.|..|.:.. |..:|||.|....:||:||...|
Human   263 DAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHT-LATVPCDGCSYAKYCSQECLQQA 326

  Fly   262 MQTYHRYECPIIDFLNRMFNKIHC-IALRTTLVALNIFPSIEELI-DFCEQEQNQDKCAFD---- 320
            .:.|||.|||:...|..:  .:.| ||||.||  |..|..:.::| ..|::..|:|.|..:
Human   327 WELYHRTECPLGGLLLTL--GVFCHIALRLTL--LVGFEDVRKIITKLCDKISNKDICLPESNNQ 387

  Fly   321 ---LNYN----------ELTP----------EEHYRAIHGLVTNQHLRSVSDLFQ----RSVVCA 358
               |||.          ..||          |.:|.|:..|:.:....|....|.    .|.:|.
Human   388 VKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCR 452

  Fly   359 VLKHFIIEYTPVKEYLGGEE-----------GVNFFTDLLFRHLQTSPSNMHGIDLVEQVNETKD 412
            .|:...::..|.:..:...:           .|..:...:.||:.....|...:..::.......
Human   453 QLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGS 517

  Fly   413 DQTHS------SGAYAFLSLINHSCAPNTVRIYEGTKAYMFVLRPIKAGNVLYDNYGAHFAICSK 471
            ..|.|      :|.:..:||:||||:|||...:..|.|.:...:.|:.|..:...||.|.:....
Human   518 IVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYGPHKSRMGV 582

  Fly   472 EQRLKRLSLQYRFDCKCEGCELNYPMFGMMP-------HKATVPSVTDDTELALSSYNYDFAVSN 529
            .:|.::|..||.|||.|..|:.........|       :....|...||.....|....:.|||.
Human   583 AERQQKLRSQYFFDCACPACQTEAHRMAAGPRWEAFCCNSCGAPMQGDDVLRCGSRSCAESAVSR 647

  Fly   530 YRKYCDFLTQYGDDYPCEQISSAEECLKMALHIMAD 565
                         |:...::...::.:::|..::.|
Human   648 -------------DHLVSRLQDLQQQVRVAQKLLRD 670

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.