DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8888 and Rdh7

DIOPT Version :9

Sequence 1:	NP_610724.1	Gene:	CG8888 / 36293	FlyBaseID:	FBgn0033679	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_598227.3	Gene:	Rdh7 / 360420	RGDID:	631370	Length:	317	Species:	Rattus norvegicus

Alignment Length:	291	Identity:	95/291 - (32%)
Similarity:	149/291 - (51%)	Gaps:	17/291 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VW-FALATVG----AVLFYHFVKVS-ASGKGVLITGCEAPLAWYLAKKLDDLGFTVYAGFNTPIE 131
            :| :.||.||    ..||.....|| ...|.|.||||::.....||::||..|..|.|...|
  Rat     1 MWLYLLALVGLWNLLRLFRERKVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLT--- 62

  Fly   132 ESDEAKILKEVTSGRMKLLHLDVTSEKTILEAARYVSQHLPHGAEGLWSVVHCAH-WIALGELEW 195
             ...|:.|:..||.|::.:.||||..::|:.|.::|.:.:  |..|||.:|:.|. .:.:|..||
  Rat    63 -EKGAEQLRSKTSDRLETVILDVTKTESIVAATQWVKERV--GNRGLWGLVNNAGISVPMGPNEW 124

  Fly   196 IPFAVLRKSLDLNLLGSARLTQIFLPLVRRAHGRVVFLTSGLNRVPSPVRGIQCATQAAVDCFAA 260
            :........||:||||...:|...|||||:|.||||.:.|.:.|: |.:.|..|.::..|:.|:.
  Rat   125 MRKKDFASVLDVNLLGVIEVTLNMLPLVRKARGRVVNIASTMGRM-SLLGGGYCISKYGVEAFSD 188

  Fly   261 CLRQEMRTRGVDVSVVAAGEFAPGNGWLNETELRDQAKQMWNQLSSEQKKTYGEDYYEAAMTSVE 325
            .||:|:...||.|:::..|.|.  ....|...|.|..|::|:|.:.|.|:.|||.:.::.|.::|
  Rat   189 SLRRELTYFGVKVAIIEPGGFK--TNVTNMERLSDNLKKLWDQATEEVKEIYGEKFRDSYMKAME 251

  Fly   326 KYSRQ-AADIQPTLRVLIDAVTRTFPMARYT 355
            ..... :.|:......:..|:|...|..||:
  Rat   252 SLVNMCSGDLSLVTDCMEHALTSCHPRTRYS 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8888	NP_610724.1	NADB_Rossmann	96..380	CDD:304358	86/262 (33%)
CG8888	NP_610724.1	adh_short	96..293	CDD:278532	68/197 (35%)
Rdh7	NP_598227.3	type2_17beta_HSD-like_SDR_c	30..306	CDD:187665	86/262 (33%)
Rdh7	NP_598227.3	adh_short	30..214	CDD:278532	67/192 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5601
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4098
OMA	1	1.010	-	-		QHG48608
OrthoDB	1	1.010	-	-		D370032at33208
OrthoFinder	1	1.000	-	-		FOG0000161
OrthoInspector	1	1.000	-	-		otm45679
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43313
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X110
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080