Protein Alignment CG8888 and HSD17B13

DIOPT Version :10

• Sequence 1: NP_610724.1
• Gene: CG8888 / 36293
• FlyBaseID: FBgn0033679
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_835236.2
• Gene: HSD17B13 / 345275
• HGNCID: 18685
• Length: 300
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 63/323 - (19%)
• Similarity: 117/323 - (36%)
• Gaps: 86/323 - (26%)

  Fly    92 SASGKGVLITGCEAPLAWYLAKKLDDLGFTVYAGFNTPIEESDEAKIL---------KEVTSGRM 147
            |.:|:.|||||.               |..:  |..|..|.:....||         .|.|:...
Human    33 SVAGEIVLITGA---------------GHGI--GRQTTYEFAKRQSILVLWDINKRGVEETAAEC 80

  Fly   148 KLL----H---LDVTSEKTILEAARYVSQHLPHGAEGLWSVVHCAHWIALGELEWIPFAVLRKSL 205
            :.|    |   :|.::.:.|..:...|.:.:    ..:..||:.|..:...:|.......:.|:.
Human    81 RKLGVTAHAYVVDCSNREEIYRSLNQVKKEV----GDVTIVVNNAGTVYPADLLSTKDEEITKTF 141

  Fly   206 DLNLLGSARLTQIFLP-LVRRAHGRVVFLTSGLNRVPSPVRGIQCATQAAVDCFAACLRQEMRT- 268
            ::|:||...:|:..|| ::.|.||.:|.:.|.......|.....|:::.|...|...|..|::.
Human   142 EVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQAL 206

  Fly   269 --RGVDVSVVAAGEFAPGNGWLNETELRDQAKQMWNQLSSEQKKTYGEDYYEAAMTSVEKYSRQA 331
              .|:..|.:..       .::|....::.:.::|..|.:::
Human   207 GKTGIKTSCLCP-------VFVNTGFTKNPSTRLWPVLETDE----------------------- 241

  Fly   332 ADIQPTLRVLIDAVTRTFPMARYTP--VTSSERLQIFLAEHLAPSL-------YESLYGEQKK 385
                 .:|.|||.:.....|. :.|  :....|||.||.|..:..|       :|::.|.:.|
Human   242 -----VVRSLIDGILTNKKMI-FVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIK 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8888	NP_610724.1	Rossmann-fold NAD(P)(+)-binding proteins	96..380	CDD:473865	59/312 (19%)
HSD17B13	NP_835236.2	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	57/295 (19%)