DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8888 and Wwox

DIOPT Version :9

Sequence 1:	NP_610724.1	Gene:	CG8888 / 36293	FlyBaseID:	FBgn0033679	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster

Alignment Length:	282	Identity:	53/282 - (18%)
Similarity:	91/282 - (32%)	Gaps:	95/282 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 GKGVLITGCEAPLAWYLAKKLDDLGF-TVYAGFNTPIEESDEAKILKE--VTSGRMKLLHLDVTS 156
            |:..||||....:.:..|:.|...|. .::|..|....|:...:|.:|  ....|.:...||::|
  Fly   121 GRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSS 185

  Fly   157 EKTILEAARYVSQHLPH--------------------GAEGLWSVVHCAHWIALGELEWIPFAVL 201
            .:::......:.|.:.|                    |.|..:.|.|.:|:....:||.:
  Fly   186 LRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETL----- 245

  Fly   202 RKSLDLNLLGSARLTQIFLPLVRRAHGRVVFLTSGLNRVPS-PVRGI--------------QCAT 251
               .|...                   |::.|:|..:|..: ||..:              ..|.
  Fly   246 ---FDYKT-------------------RIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAY 288

  Fly   252 QAAVDC---FAACLRQEMRTRGVDVSVVAAGEFAPGNGWLNETELRDQAKQMWNQLSSEQKKTYG 313
            ..|..|   ||..|.|..:.||:.|..:..|                      |.:||:..:.|.
  Fly   289 NNAKLCNVLFAQELAQRWKQRGISVFSLHPG----------------------NMVSSDLSRNYW 331

  Fly   314 EDYYEAAMTSVEKYSR---QAA 332
              :|......|..:::   |||
  Fly   332 --FYRLLFAIVRPFTKSLQQAA 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8888	NP_610724.1	NADB_Rossmann	96..380	CDD:304358	52/281 (19%)
CG8888	NP_610724.1	adh_short	96..293	CDD:278532	43/237 (18%)
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	53/282 (19%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	53/282 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930