Protein Alignment CG8888 and HSD17B2

DIOPT Version :9

• Sequence 1: NP_610724.1
• Gene: CG8888 / 36293
• FlyBaseID: FBgn0033679
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_002144.1
• Gene: HSD17B2 / 3294
• HGNCID: 5211
• Length: 387
• Species: Homo sapiens
• Alignment Length: 383
• Identity: 103/383 - (26%)
• Similarity: 172/383 - (44%)
• Gaps: 50/383 - (13%)

  Fly    20 GSISALPQKSHEIPWDIFERLFMPFLFCQAAAIVTSHLLHALDISSISTFAVFVW-FALATVGAV 83
            |::....:||....|.        ::.|.|.       |.|:.:..:|.|    | ..|.:|...
Human    21 GTVFCKYKKSSGQLWS--------WMVCLAG-------LCAVCLLILSPF----WGLILFSVSCF 66

  Fly    84 LFYHFVK----VSASGKGVLITGCEAPLAWYLAKKLDDLGFTVYAGFNTPIEESDEAKILKEVTS 144
            |.|.::.    :....|.||:||.:..|...|.|.||:|||||:||...  |....|:.|:...|
Human    67 LMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLN--ENGPGAEELRRTCS 129

  Fly   145 GRMKLLHLDVTSEKTILEAARYVSQHLPHGAEGLWSVVHCAHWIAL---GELEWIPFAVLRKSLD 206
            .|:.:|.:|:|....|.:|...|:..|..  .|||:|::.|..:..   |||  :.....::.:.
Human   130 PRLSVLQMDITKPVQIKDAYSKVAAMLQD--RGLWAVINNAGVLGFPTDGEL--LLMTDYKQCMA 190

  Fly   207 LNLLGSARLTQIFLPLVRRAHGRVVFLTSGLNRVPSPVRGIQCATQAAVDCFAACLRQEMRTRGV 271
            :|..|:..:|:.||||:|::.||:|.::|.....|........:::|||..|::.:|.|:...|:
Human   191 VNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGI 255

  Fly   272 DVSVVAAGEF-----APGNGWLNETELRDQAKQMWNQLSSEQKKTYGEDYYEAAMTSVEKYSRQA 331
            .|:.:..|.|     ...:.|      ....|.:.:.|.:|.::.||:||..|....:...:..|
Human   256 KVASIQPGGFLTNIAGTSDKW------EKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLA 314

  Fly   332 A-DIQPTLRVLIDAVTRTFPMARYTPVTSSERLQIFLAEHLAPSLYESL----YGEQK 384
            : |..|.||.:..|:....|.|.||| .....|.|.||.:|...:|:..    :|:.|
Human   315 SKDFSPVLRDIQHAILAKSPFAYYTP-GKGAYLWICLAHYLPIGIYDYFAKRHFGQDK 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8888	NP_610724.1	NADB_Rossmann	96..380	CDD:304358	86/296 (29%)
		adh_short	96..293	CDD:278532	61/204 (30%)
HSD17B2	NP_002144.1	type2_17beta_HSD-like_SDR_c	83..362	CDD:187665	86/291 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D370032at33208
OrthoFinder	1	1.000	-	-		FOG0000161
OrthoInspector	1	1.000	-	-		otm41558
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820