DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8888 and Hsd11b2

DIOPT Version :9

Sequence 1:	NP_610724.1	Gene:	CG8888 / 36293	FlyBaseID:	FBgn0033679	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_058777.1	Gene:	Hsd11b2 / 25117	RGDID:	2835	Length:	400	Species:	Rattus norvegicus

Alignment Length:	372	Identity:	105/372 - (28%)
Similarity:	157/372 - (42%)	Gaps:	64/372 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RLFMPFLFCQAAAIVTSHLLHALD---------ISSISTFAVFVWFALATVGAVLFYHFVKVSAS 94
            ||..|.|    ||:.   ||.|||         .:::...|...|.||:.:...     .::..:
  Rat    29 RLGRPLL----AALA---LLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARP-----PRLPVA 81

  Fly    95 GKGVLITGCEAPLAWYLAKKLDDLGFTVYA---GFNTPIEESDEAKILKEVTSGRMKLLHLDVTS 156
            .:.||||||:.......|||||.:||||.|   ..|.|     .|..|:...|.|:|||.:|:|.
  Rat    82 TRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNGP-----GALELRARCSPRLKLLQMDLTK 141

  Fly   157 EKTILEAARYVSQHLPHGAEGLWSVVHCAHW-IALGELEWIPFAVLRKSLDLNLLGSARLTQIFL 220
            .:.|.........|.  .:.|||.:|:.|.. :.:.::|..|....|:.:::|..|:..||:..|
  Rat   142 PEDISRVLEITKAHT--ASTGLWGLVNNAGLNMVVADVELSPVVTFRECMEVNFFGALELTKGLL 204

  Fly   221 PLVRRAHGRVVFLTSGLNRVPSPVRGIQCATQAAVDCFAACLRQEMRTRGVDVSVVAAGEFAPGN 285
            ||:|.:.||:|.:.|....:|.|.......::||:.........|:...|:.||::..|.|
  Rat   205 PLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFSCELLPWGIKVSIIQPGCF---- 265

  Fly   286 GWLNETE------LRDQAKQ-MWNQLSSEQKKTYGEDYYEAAMTSVEKYSRQA-ADIQPTLRVLI 342
                :||      |.::.|| :...|..|..:.|||||.|..........|.| .|:.|.:..:|
  Rat   266 ----KTEAVTNVNLWEKRKQLLLANLPRELLQAYGEDYIEHLHGQFLNSLRMALPDLSPVVDAII 326

  Fly   343 DAVTRTFPMAR---------------YTPVTSSER-LQIFLAEHLAP 373
            ||:....|.:|               |.|.....| ||.|...||.|
  Rat   327 DALLAAQPRSRYYTGRGLGLMYFIHHYLPGGLRRRFLQNFFISHLLP 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8888	NP_610724.1	NADB_Rossmann	96..380	CDD:304358	90/306 (29%)
CG8888	NP_610724.1	adh_short	96..293	CDD:278532	61/206 (30%)
Hsd11b2	NP_058777.1	type2_17beta_HSD-like_SDR_c	83..363	CDD:187665	84/294 (29%)
		adh_short	83..278	CDD:278532	62/209 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5601
eggNOG	1	0.900	-	-		E1_KOG1610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D370032at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X110
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820