DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8888 and dhs-29

DIOPT Version :9

Sequence 1:	NP_610724.1	Gene:	CG8888 / 36293	FlyBaseID:	FBgn0033679	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_509294.1	Gene:	dhs-29 / 181027	WormBaseID:	WBGene00000992	Length:	427	Species:	Caenorhabditis elegans

Alignment Length:	289	Identity:	58/289 - (20%)
Similarity:	110/289 - (38%)	Gaps:	60/289 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 FAVFVWFALATVGAVLFYHFVKV-------------SASGKGVLITGCEAPLAWYLAKKLDDLGF 120
            :..:.|...:|:|..|...|:.:             |..|:.|:|||..:.|...:|     |.|
Worm     2 YTSWAWKLWSTLGVALRILFIDIPMDIHRFLNLRQKSVQGQTVIITGGGSGLGRAMA-----LDF 61

  Fly   121 TVYAGFNTPIEESDEA--KILKEVTS-GRM-KLLHLDVTSEKTILEAARYVSQHLPHGAEGLWSV 181
            .........|:.:.|.  :.:|.:.: |.| |..:.|::....:.:.|:.:....     |..::
Worm    62 AKRKAKVAIIDVNKEGGLETVKTIAAEGNMAKFWYCDISDVDNMKKTAKEIEDTF-----GDVNI 121

  Fly   182 VHC-AHWIALGELEWIPFAVLRKSLDLNLLGSARLTQIFLP-LVRRAHGRVVFL---------TS 235
            |.| |..::......|...:|||.||:|:.|:....:.||| :..:..|.:|.:         |.
Worm   122 VICNAAILSFTSFMEISDELLRKCLDVNIFGTINTIRAFLPKMETKNDGHIVCVCSIAGWSGETM 186

  Fly   236 GLNRVPSPVRGIQCATQAAVDCFAACLRQEMRTRGVD-------------VSVVAAGEFAPGNGW 287
            ||:         .|.::.||......|:.|:|.||::             ..::......|...|
Worm   187 GLS---------YCTSKFAVRGAMESLQMELRDRGLEGIKTTTLYPYFARTPMILENNMRPTCTW 242

  Fly   288 LNETELRDQAKQMWNQLSSEQKKTYGEDY 316
            .....:|..:|:|.:.:..|:...:...|
Worm   243 FPFMSIRSCSKRMVDSILKEKVHAFVPSY 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8888	NP_610724.1	NADB_Rossmann	96..380	CDD:304358	51/249 (20%)
CG8888	NP_610724.1	adh_short	96..293	CDD:278532	46/224 (21%)
dhs-29	NP_509294.1	adh_short	42..230	CDD:278532	44/206 (21%)
		NADB_Rossmann	43..281	CDD:304358	51/248 (21%)
		DUF4499	322..416	CDD:291595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910