DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8888 and Bdh1

DIOPT Version :9

Sequence 1:	NP_610724.1	Gene:	CG8888 / 36293	FlyBaseID:	FBgn0033679	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_446447.2	Gene:	Bdh1 / 117099	RGDID:	620131	Length:	344	Species:	Rattus norvegicus

Alignment Length:	292	Identity:	93/292 - (31%)
Similarity:	157/292 - (53%)	Gaps:	5/292 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 SASGKGVLITGCEAPLAWYLAKKLDDLGFTVYAGFNTPIEESDEAKI--LKEVTSGRMKLLHLDV 154
            :||||.||:|||::...:.|||.|...||.|:||  ..:::..:|.:  |..:.|.|::.:.|:|
  Rat    53 AASGKAVLVTGCDSGFGFSLAKHLHSKGFLVFAG--CLLKDKGDAGVRELDSLKSDRLRTIQLNV 115

  Fly   155 TSEKTILEAARYVSQHLPHGAEGLWSVVHCAHWIALGELEWIPFAVLRKSLDLNLLGSARLTQIF 219
            .:.:.:.:|...|...|....:|:|.:|:.|.....||:|:......::..::||.|:.|.|:.|
  Rat   116 CNSEEVEKAVETVRSGLKDPEKGMWGLVNNAGISTFGEVEFTSMETYKEVAEVNLWGTVRTTKSF 180

  Fly   220 LPLVRRAHGRVVFLTSGLNRVPSPVRGIQCATQAAVDCFAACLRQEMRTRGVDVSVVAAGEFAPG 284
            |||:|||.||||.::|.|.|:.:|.|...|.|:..|:.|:.|||.||...||.||||..|.|...
  Rat   181 LPLLRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMHPLGVKVSVVEPGNFIAA 245

  Fly   285 NGWLNETELRDQAKQMWNQLSSEQKKTYGEDYYEAAMTSVEKYSRQ-AADIQPTLRVLIDAVTRT 348
            ....:...::..||:||::|....:|.||:.|::..:..:|.|... :.|....:..:..|:|..
  Rat   246 TSLYSPERIQAIAKKMWDELPEVVRKDYGKKYFDEKIAKMETYCNSGSTDTSSVINAVTHALTAA 310

  Fly   349 FPMARYTPVTSSERLQIFLAEHLAPSLYESLY 380
            .|..||.|:.....|::.:..|...::.:.:|
  Rat   311 TPYTRYHPMDYYWWLRMQVMTHFPGAISDKIY 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8888	NP_610724.1	NADB_Rossmann	96..380	CDD:304358	89/286 (31%)
CG8888	NP_610724.1	adh_short	96..293	CDD:278532	69/198 (35%)
Bdh1	NP_446447.2	type2_17beta_HSD-like_SDR_c	57..342	CDD:187665	89/286 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5601
eggNOG	1	0.900	-	-		E1_KOG1610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4098
OMA	1	1.010	-	-		QHG48608
OrthoDB	1	1.010	-	-		D1390068at2759
OrthoFinder	1	1.000	-	-		FOG0000161
OrthoInspector	1	1.000	-	-		otm45679
orthoMCL	1	0.900	-	-		OOG6_109704
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.740