Protein Alignment Drep3 and Cidea

DIOPT Version :10

• Sequence 1: NP_610722.2
• Gene: Drep3 / 36292
• FlyBaseID: FBgn0028407
• Length: 266
• Species: Drosophila melanogaster
• Sequence 2: NP_031728.2
• Gene: Cidea / 12683
• MGIID: 1270845
• Length: 217
• Species: Mus musculus
• Alignment Length: 1165
• Identity: 208/1165 - (17%)
• Similarity: 363/1165 - (31%)
• Gaps: 373/1165 - (32%)

  Fly    57 RLNELVSRSDGDLTRVMQLFGKVSTEVTASRERIQVVKENLQSCKQLLRCRRDELKKLYTDAIQH 121
            |..:..||..||.|....       ||.:::..:...|....:.|..:..:|..||...||..:.
Mouse     4 RFGKTYSRKGGDGTSKFD-------EVLSNKRAMLSTKWGETTYKAKVGAKRPGLKTEVTDQTKR 61

  Fly   122 KYVLE--------MLDQITEIRKVPAQLTAFMAKKHYLHATKLLMASI----ETTDGKLKGVEGL 174
            ..|.|        ..|...|.:.|.::..| .:|.....:|....||:    .:...:...||.:
Mouse    62 SKVSEGDGSEDPFGFDSDDESKPVTSRNIA-QSKAKVTSSTGGSQASLTLEPNSRVNQPASVEAV 125

  Fly   175 NDLRQDFQNRRQQLYGKLLEELNKHLYVSSTADVLQNFQRQASGRNSQYAAGTSPFQRNVLRRSA 239
            ...|..|....::...|:.|:..|:...|:|... .::..:::.|:| |:...:|
Mouse   126 APSRASFSLSSERSAHKVPEDPGKYFNTSTTGKT-PSWPAESTDRHS-YSWYKNP---------- 178

  Fly   240 ERVEANTKARKALFEISKNGFLDVDKSEIIEDTELLDPDVNSSYFLSIIVECFALLQKVPESIES 304
              .|.:|:      .:::...|   |||..||.:..|.       .|.:|...|      .|...
Mouse   179 --SECDTR------PLAQTTTL---KSEKTEDKDSYDA-------WSAVVGLGA------RSTSL 219

  Fly   305 IKVQMQSELLAIVTKSTQHIN-----SLE-HLPQTHQ------QQQQQQQQTTLGITSTPSSSTV 357
            .....:|..:...:.|..|.|     |.| .|...||      .:..:.:..:..:...|:..|.
Mouse   220 FTAPKESSSMLWASSSYSHSNIQGKSSTETRLDNFHQGEFNVPVEPSESEDHSQSVLRAPNCRTY 284

  Fly   358 ATCN--GTPSGASSADPTQPAQPVPILELLDLVFKQFKLIANAHQQALRN--------YGNVIQR 412
            ...|  ..|.||..:..........:|:.:.        ..||.:...|.        :.:.:..
Mouse   285 CRPNKGKQPGGADGSGSASSHISTGVLQTIG--------TDNASKTTNRGRTRDFTVLHPSCVSM 341

  Fly   413 YNIPQVKPYD--IIEYWGQAQAVLKLVLTDYLDIQNDSGDEALLLRGQFAEQSTNVNAFFSRRKT 475
            :|:......|  :.||....||             :..|||..|.:....|......:..::.|.
Mouse   342 FNVTFQDSMDRSVEEYTASTQA-------------SGPGDEGRLKKKTETESKPLSRSRPTQSKM 393

  Fly   476 PGKKL-LFRFDKSSHTAD----AGGPQT-------------ADGDTGGTKEHRRNL--------- 513
            ...|| ||.||.:...||    |.|..:             :|.:......|||..
Mouse   394 KSSKLELFGFDDTDAVADDDDSASGSSSYRIKYFGFDDLSESDSEEEEGSSHRRRAKRMAAAEAE 458

  Fly   514 ------SNVSNSTPKEEALLNSSAVSANSSHLLNSSFHQHQPYYF---------------GGKDA 557
                  :||.:..|:|   :.||..|..:.|.|     :|.|..|               ..::.
Mouse   459 PLLSIDTNVDSPPPRE---MQSSHSSYTAGHSL-----KHDPLEFPDIPFPFETVRKPQVKAQEK 515

  Fly   558 AAERRK-------------------------------RERALVCPADAS---------------- 575
            |.|.|:                               ..|:...||.||
Mouse   516 AKESRRIFSGPKKSPTKAVYNARHWNQPEAEEMLPMPPSRSQAPPAAASGGSKESNSHKDDGVFK 580

  Fly   576 -------LVRKIYLPLMGYIQEIESFMKCKSGQPCSLNTFLANYVKD-----------------A 616
                   :::.:.:|...| |::.:.:||:. :...|.| :..:||.                 .
Mouse   581 APAPPPKVIKSVTIPTEPY-QDMVTALKCRK-EHKELYT-VVQHVKHFNDVVEFGENQEFTDDFE 642

  Fly   617 YLARGHNRNLQLTIESLSKAQDAWRTIISPEEMKRLGLTRPLLQNTLIVENRIAETKKLIQDLPT 681
            |||.|......|....||....|.|..:            |..:..|....::|:..|.:.|.|.
Mouse   643 YLATGLKTGQPLNTRCLSVISLATRCAM------------PSFRMHLRARGKVAQVFKTLGDAPQ 695

  Fly   682 YSDELLKMVCSLLKTYRETCQAAYRGIVQPETEDKRIYSVAWLKDDDITRFLKSLPNWTDLKSSN 746
            :|:..|             |.|:...|:..:..:.           |:.|  .||    ||.
Mouse   696 HSNLAL-------------CTASLMYILSRDRLNM-----------DLDR--ASL----DLM--- 727

  Fly   747 ARLRQLQQKRLMKTEPSEEESPTQVQQR------NVREAEMLTSNLGEGGISQQEILSDVGV--- 802
            .||.:|:|.:.:..:.:.:|. .:|:::      .|....:...|:..|.::.:.:||....
Mouse   728 IRLLELEQDKSIADQLTTKEM-NKVKEKIRKLCETVHNKHLDLENITTGHLAMETLLSLTSKRAG 791

  Fly   803 --LKELAILQESMEWFASRITEFAHDL-----KKPIVNGLVAAS------PVTTPGSPSPAGTAT 854
              .||...|...::....::.|...:|     |:.:|..|..|.      ...|..:|...|..
Mouse   792 DWFKEELRLLGGLDHIVDKVKECVENLSREDDKENLVASLWGAERCLRVLESVTVHNPENQGYL- 855

  Fly   855 IVNSPVIVKDGMIKVLINLALEFEELANTCLLVLHLEVRVQCFHYLRSSPSDRYK---------- 909
                 :..||..:.|....||.            |.|..:|           ||.
Mouse   856 -----IAYKDSQLIVSSAKALR------------HCEEMIQ-----------RYSREMNRGLCTT 892

  Fly   910 ---ANNPNKNDSLEPDAK-----VLKLT-------KVLSDMDEALSSTLH---------PRKTKY 950
               .:|.|...::|...:     :|.||       ....:.|:.:::.|:         |::.::
Mouse   893 LPFCSNSNVGKAVEDCMRAIIGVLLNLTHDNEWGSTKTGEQDDLITTALNCVLKVPQYLPQEQRF 957

  Fly   951 VFEGLAHLAARILIMAANSMEYIDHSGVQRMCRNALALQ--QTLSSITASREVALDYARS 1008
               .:..|...:||   |.:||   |...|.|...|.::  :...|:..|.:..|...||
Mouse   958 ---DIRVLGLGLLI---NLVEY---SARNRHCLVELQMEGGEVWDSMCVSDKDELQTERS 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drep3	NP_610722.2	CIDE_N	119..192	CDD:119367	14/84 (17%)
Cidea	NP_031728.2	CIDE_N_A	33..110	CDD:119372	17/77 (22%)
		Amphipathic helix. /evidence=ECO:0000269|PubMed:26609809	163..180		4/29 (14%)