DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIII128 and POLR1B

DIOPT Version :9

Sequence 1:	NP_523706.1	Gene:	RpIII128 / 36289	FlyBaseID:	FBgn0004463	Length:	1137	Species:	Drosophila melanogaster
Sequence 2:	NP_001358898.1	Gene:	POLR1B / 84172	HGNCID:	20454	Length:	1181	Species:	Homo sapiens

Alignment Length:	1256	Identity:	361/1256 - (28%)
Similarity:	556/1256 - (44%)	Gaps:	219/1256 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DPGDSKDW-SVP----IKPLTEKWKLVPAFLQ---VKGLVKQHIDSFNHFINVDIKKIVKANELV 73
            |||..  | ::|    :|.||:....:|...|   ::.|.:.|::|||:.::..:...|:
Human     2 DPGSR--WRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQ----- 59

  Fly    74 TSGADPLFYLKY---------LDVRVGKPDIDDGFNITKATT-PHECRLRDTTYSAPITVDIEY- 127
               |.|.|...:         ||..:..|.:..|....:|.. |.|||.|.:||...:|.||.:
Human    60 ---AIPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINWA 121

  Fly   128 TRGTQR--IKRNNLLIGRMPLMLRCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVI--LI 188
            ..|..:  ||:   .:|.:|:|::...|.|.......|.:.:|...:.||||::.|.||||  ||
Human   122 VNGISKGIIKQ---FLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIRMLI 183

  Fly   189 QEQLSWN-KMLTEDFN----GVVQCQVTSSTHEKKSRTLVLSKHGKYYLKHNSMTDD-------- 240
            ..:.::. .|:...:.    |..|..|:.....::...:.::.|   ||::.::..:
Human   184 MPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLH---YLENGTVMLNFIYRKELF 245

  Fly   241 -IPIVVIFKALGVVSDQEI-QSLI---GIDSKSQNRFGASLIDAYNLKVFTQQRALEYMGSKLVV 300
             :|:....|||...||.:| |.||   ..||..:|.....|.........||::.|.|:|....|
Human   246 FLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQVLNYLGECFRV 310

  Fly   301 KRFQSATTKTPSEEARELLLT-TILAHVPVDNFNLQMKAIYVSMMVRRVMAAELDKTLFDDRDYY 364
            |  .:.....|:|:|.|.|.. .|..|:..:.....|    :.:|.|::.|....:.:.|:.|..
Human   311 K--LNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYM----LCLMTRKLFALAKGECMEDNPDSL 369

  Fly   365 GNKRLELAGSLLSMMFEDLFKRMNW--ELKTIADK------------NIPKVKAAQFDVVKHMRA 415
            .|:.:...|.|..|..::  |...|  .:|...||            |:.::.....|:.|....
Human   370 VNQEVLTPGQLFLMFLKE--KLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIFTMGIDLTKPFEY 432

  Fly   416 AQITAGLESAISSGNWTIKRFKMERAGVTQVLSRLSYISALGMMTRVN--SQFEKTRKVSGPRSL 478
            ...|..|.|....|       .::.:|:..|..:|::|..|.....|:  :.|.|.|..: .|.|
Human   433 LFATGNLRSKTGLG-------LLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAKMRTTT-VRRL 489

  Fly   479 QPSQWGMLCPSDTPEGEACGLVKNLALMTHITTE-VEERPVMIVAFNAGVEDIREVSGNPINN-P 541
            .|..||.|||..||:||.|||:.:|..:..:.|: |....:..:..|.||..|   .|.|..: .
Human   490 LPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVTPI---DGAPHRSYS 551

  Fly   542 NVFLVFINGNVLG-----LTLNHKHLVRNLRYMRRKGRM--GSYVSVHTSYTQRC---------- 589
            ..:.|.::|.::|     |.......:|:.:.:....|:  ...:..|.|....|
Human   552 ECYPVLLDGVMVGWVDKDLAPGIADSLRHFKSLALSPRLQCSGVILAHCSLRLPCSSNSPASVSQ 616

  Fly   590 ---------------------------------------IYIHTDGGRLCRPYVIVENRRPLVKQ 615
                                                   :::.|...||.||   |:| ..|.|:
Human   617 VAGITGAHHHAWVLREKRIPPWMEVVLIPMTGKPSLYPGLFLFTTPCRLVRP---VQN-LALGKE 677

  Fly   616 HHLDELNRGIRKFDDFLLDGLIEYLDVNEENDSFIAWNEDQI-EDRTTHLEIEPFTLLGVCAGLV 679
            .                |.|.:|.:.:|      :|..||:: ...|||.|:.|.:||.|.|..:
Human   678 E----------------LIGTMEQIFMN------VAIFEDEVFAGVTTHQELFPHSLLSVIANFI 720

  Fly   680 PYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNFDKLPAGQ 744
            |:..|||||||.|||.||||.||......::|.|:.:|.|..|.:|:|:....:..:.|..|.|.
Human   721 PFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIGT 785

  Fly   745 NATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDRIMGPMKDALTNKV 809
            ||.|||:||:|||:|||:|:||||.:||:....|||:....:.....|....::..:|.. ..:|
Human   786 NAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKIKQGDSSLVFGIKPG-DPRV 849

  Fly   810 IFKHDVLDTDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQGQSAQVPYTAVPISYKGPEPSYIER 874
            :.|   ||.||:...|.::|...       |..:.:|...|:|. |.|      ||..|...::.
Human   850 LQK---LDDDGLPFIGAKLQYGD-------PYYSYLNLNTGESF-VMY------YKSKENCVVDN 897

  Fly   875 VMVSANAEEDFLIK---ILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGICPDMIMN 936
            :.|.:|.......|   |.:|..|.|.|||||:|||||||:...:...|||||.:.|:.||::.|
Human   898 IKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFN 962

  Fly   937 PHGFPSRMTVGKTLELLGGKAGLLEGKFHYGTAF----GGSKVEDIQAELERHGFNYVGKDFFYS 997
            |||||||||:|..:|.:.||:..|.|..|..|.|    ..|.:|.....|:..|:|:.|.:..||
Human   963 PHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYS 1027

  Fly   998 GITGTPLEAYIYSGPVYYQKLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDCLI 1062
            ||:|..|||.|:.|.||||:|:|||.||...|..|.:..:|.||..||:.:||:|.||||||.|:
Human  1028 GISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALL 1092

  Fly  1063 SYGASMLIMERLMISSDAFEVDVCRTCGRMAY-------CSW---------CHFCQSSANVSKIS 1111
            ::|.|.|:.:||...||.....||..||.:..       .||         |..|..|..:..:|
Human  1093 AHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTVS 1157

  Fly  1112 MPYACKLLFQELTSMNVVPKM 1132
            :||..:....||.:||:..|:
Human  1158 VPYVFRYFVAELAAMNIKVKL 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIII128	NP_523706.1	PRK08565	34..1135	CDD:236291	353/1234 (29%)
		RNA_pol_B_RPB2	47..1133	CDD:238353	351/1218 (29%)
		RNA_pol_Rpb2_2	210..370	CDD:282427	39/173 (23%)
		RNA_pol_Rpb2_4	546..607	CDD:282431	14/116 (12%)
		RNA_pol_Rpb2_5	628..668	CDD:282432	11/40 (28%)
POLR1B	NP_001358898.1	RNA_pol_B_RPB2	38..1179	CDD:238353	351/1218 (29%)
		RNA_pol_Rpb2_2	186..375	CDD:367992	42/197 (21%)
		RNA_pol_Rpa2_4	563..662	CDD:369122	8/98 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820