DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIII128 and NRPA2

DIOPT Version :9

Sequence 1:	NP_523706.1	Gene:	RpIII128 / 36289	FlyBaseID:	FBgn0004463	Length:	1137	Species:	Drosophila melanogaster
Sequence 2:	NP_564341.2	Gene:	NRPA2 / 839872	AraportID:	AT1G29940	Length:	1178	Species:	Arabidopsis thaliana

Alignment Length:	1289	Identity:	350/1289 - (27%)
Similarity:	562/1289 - (43%)	Gaps:	296/1289 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DSKDWSVPIKPLTEKWKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIVKANELVTSGADPLFYLK 84
            ::||.:||         .:..|.::..||..||:||::              :...|.|.:|. :
plant     4 NAKDSTVP---------TMEDFKELHNLVTHHIESFDY--------------MTLKGLDVMFN-R 44

  Fly    85 YLDVRVGKPDIDDGFNI--------------TKATT------PHECRLRDTTYSAPITVDI--EY 127
            ...|.|..|:.::..:|              .|:|:      |.|||....:|:.....|:  :|
plant    45 IKPVSVYDPNTENELSIWLENPLVFAPQKESFKSTSRKEPLLPFECRQAKISYTGTFMADVCFKY 109

  Fly   128 TRGTQRIKRNNLLIGRMPLMLRCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKV---ILIQ 189
            ..|.  :.|:....|:.|:||....|:|.|....:|.|..|...:.||||::.|.|:|   ::..
plant   110 NDGV--VVRDKFDFGQFPIMLMSKLCSLKGADCRKLLKCKESTSEMGGYFILNGIERVFRCVIAP 172

  Fly   190 EQLSWNKMLTEDFNG----------VVQCQVTSSTHEKKSRTLVLSKHGKYYLKHNSMTDD---- 240
            ::.....|:...|..          |.:|    ...::.|.|:.|     |||::.|....
plant   173 KRNHPTSMIRNSFRDRKEGYSSKAVVTRC----VRDDQSSVTVKL-----YYLRNGSARVGFWIV 228

  Fly   241 -----IPIVVIFKALGVVSDQEI-QSLIGIDSKSQNR----FGASLI---------DAYNLKVFT 286
                 :|:.::.|||....|:|| :||....|:...|    .|..|:         :..:|.:||
plant   229 GREYLLPVGLVLKALTNSCDEEIYESLNCCYSEHYGRGDGAIGTQLVRERAKIILDEVRDLGLFT 293

  Fly   287 QQRALEYMGSKLVVKRFQSATTKTPSEE----ARELLLTTILAHVPVDN--FNLQMKAIYVSMMV 345
            :::..:::|     :.||........|.    |..:|...:..|:..|:  |||      :..::
plant   294 REQCRKHLG-----QHFQPVLDGVKKESLSIVAEAVLRDYLFVHLDNDHDKFNL------LIFII 347

  Fly   346 RRVMAAELDKTLFDDRDYYGNKRLELAGSLLSMMFEDLFKRMNW--------------------- 389
            :::.:.....:|.|:.|...|:.:.:.|.::::..::  |...|
plant   348 QKLYSLVDQTSLPDNPDSLQNQEILVPGHVITIYLKE--KLEEWLRKCKSLLKDELDNTNSKFSF 410

  Fly   390 ----ELKTIADKNIPKVKAAQFDVVKHMRAAQITAGLESAISSGNWTIKRFKMERAGVTQVLSRL 450
                ::|.:.:||.|:......:.:....|.:..:||:             ..:|||.|....||
plant   411 ESLADVKKLINKNPPRSIGTSIETLLKTGALKTQSGLD-------------LQQRAGYTVQAERL 462

  Fly   451 SYISALGMMTRVN--SQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTEV 513
            :::..|.....|:  :.|...|..: .|.|.|..||.|||..||:|..|||:.::...:.||::.
plant   463 NFLRFLSFFRAVHRGASFAGLRTTT-VRKLLPESWGFLCPVHTPDGTPCGLLNHMTRTSRITSQF 526

  Fly   514 E-----------ERPVMIVAFNAGVEDI--REVSGNPINNPNVFLVFINGNVLGLTLNHKHLVRN 565
            :           .:.|:.|...||:...  :.|...|   |.|..|.::|.|:| ||:...:.:.
plant   527 DSKGNIRDFLKIRKSVVDVLTGAGMVPSLPKLVRAGP---PKVIHVLLDGQVVG-TLSSNLVTKV 587

  Fly   566 LRYMRR-KGRMGS---------YVSVHTSYTQRCIYIHTDGGRLCRPYVIVENRRPLVKQHHLDE 620
            :.|:|| |....|         ||......:...:|:.:...|..||          ||...:..
plant   588 VSYIRRLKVEAPSVIPEDLEVGYVPTSMGGSYPGLYLASCPARFIRP----------VKNISIPS 642

  Fly   621 LNRGIRKFDDFLLDGLIE--YLDVN-------EENDSFIAWNEDQIEDRTTHLEIEPFTLLGVCA 676
                    |:..|.|..|  :::::       ..|:|.:|          ||.||.|..::.|.|
plant   643 --------DNIELIGPFEQVFMEISCPDGGNGGRNNSSLA----------THEEIHPTGMISVVA 689

  Fly   677 GLVPYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNFDKLP 741
            .|.|:..|||||||.|||.|.||.|.......:.|.|..:|:|..|.:|:|::||....:.|:.|
plant   690 NLTPWSDHNQSPRNMYQCQMAKQTMAYSTQALQFRADQKIYHLQTPQSPVVRTKTYTTYSIDENP 754

  Fly   742 AGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDRIMGPMKDALT 806
            .|.||.|||::::|:|:|||:||||:|::||.....:|:.....:.. .|..||......:.: |
plant   755 TGTNAIVAVLAHTGFDMEDAMILNKSSVERGMCHGQIYQTENIDLSD-QNSRFDSGSKSFRRS-T 817

  Fly   807 NKVIFKHDVLDTDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQGQSAQVPYTAV---------PI 862
            ||.  :|..:|.||:.:.|:::...:                       ||.::         .:
plant   818 NKA--EHFRIDADGLPSVGQKLYPDE-----------------------PYCSIYDEVTNKTRHM 857

  Fly   863 SYKGPEPSYIERVMVSANAEE-DFLIKILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFND 926
            ..||.:|..::.|.|...::: .....|..|..|.|.||||||||||||||...:....|||||.
plant   858 KRKGTDPVIVDFVSVDMKSKKHPQRANIRFRHARNPIIGDKFSSRHGQKGVCSQLWPDIDMPFNG 922

  Fly   927 F-GICPDMIMNPHGFPSRMTVGKTLELLGGKAGLLEGKFHYGTAF-------GGSK-------VE 976
            . |:.||:|:|||.||||||:...||.:..|.|.|.|||...|.|       .|.:       |:
plant   923 VTGMRPDLIINPHAFPSRMTIAMLLESIAAKGGSLHGKFVDATPFRDAVKKTNGEEESKSSLLVD 987

  Fly   977 DIQAELERHGFNYVGKDFFYSGITGTPLEAYIYSGPVYYQKLKHMVQDKMHARARGPKAVLTRQP 1041
            |:.:.|:..|||:.|.:..|||..|..|:..|:.||||||:|:|||.||...|:.|....||.||
plant   988 DLGSMLKEKGFNHYGTETLYSGYLGVELKCEIFMGPVYYQRLRHMVSDKFQVRSTGQVDQLTHQP 1052

  Fly  1042 TQGRSREGGLRLGEMERDCLISYGASMLIMERLMISSDAFEVDVCRTCGRMAYCS---------- 1096
            .:||.|.||:|.||||||.|:::|||.|:.:||..|||....|||..||.:...|
plant  1053 IKGRKRGGGIRFGEMERDSLLAHGASYLLHDRLHTSSDHHIADVCSLCGSLLTSSVVNVQQKKLI 1117

  Fly  1097 ---------------WCHFCQSSANVSKISMPYACKLLFQELTSMNVVPKMILE 1135
                           .|:.|::|..:..::|||..:.|..||.|||:  ||.|:
plant  1118 QEIGKLPPGRTPKKVTCYSCKTSKGMETVAMPYVFRYLAAELASMNI--KMTLQ 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIII128	NP_523706.1	PRK08565	34..1135	CDD:236291	345/1273 (27%)
		RNA_pol_B_RPB2	47..1133	CDD:238353	343/1258 (27%)
		RNA_pol_Rpb2_2	210..370	CDD:282427	38/188 (20%)
		RNA_pol_Rpb2_4	546..607	CDD:282431	17/70 (24%)
		RNA_pol_Rpb2_5	628..668	CDD:282432	11/48 (23%)
NRPA2	NP_564341.2	RpoB	13..1174	CDD:223163	346/1271 (27%)
		RNA_pol_B_RPB2	22..1169	CDD:238353	344/1260 (27%)
		RNA_pol_Rpb2_2	202..372	CDD:282427	38/185 (21%)
		RNA_pol_Rpa2_4	576..628	CDD:284335	11/52 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820